Characterisation of a three-dimensional Brownian motor in optical lattices

We present here a detailed study of the behaviour of a three dimensional Brownian motor based on cold atoms in a double optical lattice [P. Sjolund et al., Phys. Rev. Lett. 96, 190602 (2006)]. This includes both experiments and numerical simulations of a Brownian particle. The potentials used are spatially and temporally symmetric, but combined spatiotemporal symmetry is broken by phase shifts and asymmetric transfer rates between potentials. The diffusion of atoms in the optical lattices is rectified and controlled both in direction and speed along three dimensions. We explore a large range of experimental parameters, where irradiances and detunings of the optical lattice lights are varied within the dissipative regime. Induced drift velocities in the order of one atomic recoil velocity have been achieved.Comment: 8 pages, 14 figure

Directed transport of Brownian particles in a double symmetric potential

We investigate the dynamics of Brownian particles in internal state- dependent symmetric and periodic potentials. Although no space or time symmetry of the Hamiltonian is broken, we show that directed transport can appear. We demonstrate that the directed motion is induced by breaking the symmetry of the transition rates between the potentials when these are spatially shifted. Finally, we discuss the possibility of realizing our model in a system of cold particles trapped in optical lattices.Comment: to appear in Physical Review

Testing Stokes-Helmert geoid model computation on a synthetic gravity field: experiences and shortcomings

We report on testing the UNB (University of New Brunswick) software suite for accurate regional geoid model determination by use of Stokes-Helmert’s method against an Australian Synthetic Field (ASF) as “ground truth”. This testing has taken several years and has led to discoveries of several significant errors (larger than 5mm in the resulting geoid models) both in the UNB software as well as the ASF. It was our hope that, after correcting the errors in UNB software, we would be able to come up with some definite numbers as far as the achievable accuracy for a geoid model computed by the UNB software. Unfortunately, it turned out that the ASF contained errors, some of as yet unknown origin, that will have to be removed before that ultimate goal can be reached. Regardless, the testing has taught us some valuable lessons, which we describe in this paper. As matters stand now, it seems that given errorless gravity data on 1’ by 1’ grid, a digital elevation model of a reasonable accuracy and no topographical density variations, the Stokes-Helmert approach as realised in the UNB software suite is capable of delivering an accuracy of the geoid model of no constant bias, standard deviation of about 25 mm and a maximum range of about 200 mm. We note that the UNB software suite does not use any corrective measures, such as biases and tilts or surface fitting, so the resulting errors reflect only the errors in modelling the geoid

Demonstration of a controllable three-dimensional Brownian motor in symmetric potentials

We demonstrate a Brownian motor, based on cold atoms in optical lattices, where isotropic random fluctuations are rectified in order to induce controlled atomic motion in arbitrary directions. In contrast to earlier demonstrations of ratchet effects, our Brownian motor operates in potentials that are spatially and temporally symmetric, but where spatiotemporal symmetry is broken by a phase shift between the potentials and asymmetric transfer rates between them. The Brownian motor is demonstrated in three dimensions and the noise-induced drift is controllable in our system.Comment: 5 pages, 4 figure

Influence of the lattice topography on a three-dimensional, controllable Brownian motor

We study the influence of the lattice topography and the coupling between motion in different directions, for a three-dimensional Brownian motor based on cold atoms in a double optical lattice. Due to controllable relative spatial phases between the lattices, our Brownian motor can induce drifts in arbitrary directions. Since the lattices couple the different directions, the relation between the phase shifts and the directionality of the induced drift is non trivial. Here is therefore this relation investigated experimentally by systematically varying the relative spatial phase in two dimensions, while monitoring the vertically induced drift and the temperature. A relative spatial phase range of 2pi x 2pi is covered. We show that a drift, controllable both in speed and direction, can be achieved, by varying the phase both parallel and perpendicular to the direction of the measured induced drift. The experimental results are qualitatively reproduced by numerical simulations of a simplified, classical model of the system

Primary osteosarcoma of the breast: case report

Mammary sarcomas are very uncommon and make up less than 1% of all primary breast malignancies

Implementation of Quality Systems in Nuclear Medicine: Why It Matters. An Outcome Analysis (Quality Management Audits in Nuclear Medicine Part III).

The International Atomic Energy Agency (IAEA) developed a comprehensive program-Quality Management Audits in Nuclear Medicine (QUANUM). This program covers all aspects of nuclear medicine practices including, but not limited to, clinical practice, management, operations, and services. The QUANUM program, which includes quality standards detailed in relevant checklists, aims at introducing a culture of comprehensive quality audit processes that are patient oriented, systematic, and outcome based. This paper will focus on the impact of the implementation of QUANUM on daily routine practices in audited centers. Thirty-seven centers, which had been externally audited by experts under IAEA auspices at least 1 year earlier, were invited to run an internal audit using the QUANUM checklists. The external audits also served as training in quality management and the use of QUANUM for the local teams, which were responsible of conducting the internal audits. Twenty-five out of the 37 centers provided their internal audit report, which was compared with the previous external audit. The program requires that auditors score each requirement within the QUANUM checklists on a scale of 0-4, where 0-2 means nonconformance and 3-4 means conformance to international regulations and standards on which QUANUM is based. Our analysis covering both general and clinical areas assessed changes on the conformance status on a binary manner and the level of conformance scores. Statistical analysis was performed using nonparametric statistical tests. The evaluation of the general checklists showed a global improvement on both the status and the levels of conformances (P < 0.01). The evaluation of the requirements by checklist also showed a significant improvement in all, with the exception of Hormones and Tumor marker determinations, where changes were not significant. Of the 25 evaluated institutions, 88% (22 of 25) and 92% (23 of 25) improved their status and levels of conformance, respectively. Fifty-five requirements, on average, increased from nonconformance to conformance status. In 8 key areas, the number of improved requirements was well above the average: Administration & Management (checklist 2); Radiation Protection & Safety (checklist 4); General Quality Assurance system (checklist 6); Imaging Equipment Quality Assurance or Quality Control (checklist 7); General Diagnostic (checklist 9); General Therapeutic (checklist 12); Radiopharmacy Level 1 (checklist 14); and Radiopharmacy Level 2 (checklist 15). Analysis of results related to clinical activities showed an overall positive impact on both the status and the level of conformance to international standards. Similar results were obtained for the most frequently performed clinical imaging and therapeutic procedures. Our study shows that the implementation of a comprehensive quality management system through the IAEA QUANUM program has a positive impact on nuclear medicine practices

Comprehensive Auditing in Nuclear Medicine Through the International Atomic Energy Agency Quality Management Audits in Nuclear Medicine Program. Part 2: Analysis of Results.

The International Atomic Energy Agency has developed a program, named Quality Management Audits in Nuclear Medicine (QUANUM), to help its Member States to check the status of their nuclear medicine practices and their adherence to international reference standards, covering all aspects of nuclear medicine, including quality assurance/quality control of instrumentation, radiopharmacy (further subdivided into levels 1, 2, and 3, according to complexity of work), radiation safety, clinical applications, as well as managerial aspects. The QUANUM program is based on both internal and external audits and, with specifically developed Excel spreadsheets, it helps assess the level of conformance (LoC) to those previously defined quality standards. According to their level of implementation, the level of conformance to requested standards; 0 (absent) up to 4 (full conformance). Items scored 0, 1, and 2 are considered non-conformance; items scored 3 and 4 are considered conformance. To assess results of the audit missions performed worldwide over the last 8 years, a retrospective analysis has been run on reports from a total of 42 audit missions in 39 centers, three of which had been re-audited. The analysis of all audit reports has shown an overall LoC of 73.9 ± 8.3% (mean ± standard deviation), ranging between 56.6% and 87.9%. The highest LoC has been found in the area of clinical services (83.7% for imaging and 87.9% for therapy), whereas the lowest levels have been found for Radiopharmacy Level 2 (56.6%); Computer Systems and Data Handling (66.6%); and Evaluation of the Quality Management System (67.6%). Prioritization of non-conformances produced a total of 1687 recommendations in the final audit report. Depending on the impact on safety and daily clinical activities, they were further classified as critical (requiring immediate action; n = 276; 16% of the total); major (requiring action in relatively short time, typically from 3 to 6 months; n = 604; 36%); whereas the remaining 807 (48%) were classified as minor, that is, to be addressed whenever possible. The greatest proportion of recommendations has been found in the category "Managerial, Organization and Documentation" (26%); "Staff Radiation Protection and Safety" (17.3%); "Radiopharmaceuticals Preparation, Dispensing and Handling" (15.8%); and "Quality Assurance/Quality Control" and "Management of Equipment and Software" (11.4%). The lowest level of recommendations belongs to the item "Human Resources" (4%). The QUANUM program proved applicable to a wide variety of institutions, from small practices to larger centers with PET/CT and cyclotrons. Clinical services rendered to patients showed a good compliance with international standards, whereas issues related to radiation protection of both staff and patients will require a higher degree of attention. This is a relevant feedback for the International Atomic Energy Agency with regard to the effective translation of safety recommendations into routine practice. Training on drafting and application of standard operating procedures should also be considered a priority

The FERRUM Project: Experimentally determined metastable lifetimes and transition probabilities for forbidden [Ti II] lines observed in Carinae

ABSTRACT In the spectrum of an emission line region ejected from the massive star Eta Carinae, called the Strontium filament (SrF), forbidden lines from many elements, in particular [SrII] and [Ti II], are observed. These lines are strong in this specific region and valuable for plasma diagnostics. Forbidden lines are not easily produced in laboratory light sources and the atomic parameters for these lines can thus not be measured in a straightforward way. We use a combination of laboratory and astrophysical measurements to determine transition probabilities for the [Ti II] lines. Lifetimes for metastable levels in Ti II are measured using a laser probing technique (LPT) on a stored ion beam at CRYRING, MSL, Stockholm. Branching fractions from some of these levels are derived from HS T /STIS spectra of the SrF. The astrophysical branching fractions are combined with the experimental lifetimes to determine absolute transition probabilities. We report lifetimes for the Ti II levels b 4 P 3¢ 2 , b 2 P 1¢ 2 , c 2 D 3¢ 2 and c 2 D 5¢ 2 , in the range 0.29-17 s, and transition probabilities for eight parity forbidden lines from the levels c 2 D 3¢ 2 and c 2 D 5¢ 2 , along with uncertainty estimates

Genes targeted by the estrogen and progesterone receptors in the human endometrial cell lines HEC1A and RL95-2

<p>Abstract</p> <p>Background</p> <p>When the steroid hormones estrogen and progesterone bind to nuclear receptors, they have transcriptional impact on target genes in the human endometrium. These transcriptional changes have a critical function in preparing the endometrium for embryo implantation.</p> <p>Methods</p> <p>382 genes were selected, differentially expressed in the receptive endometrium, to study their responsiveness of estrogen and progesterone. The endometrial cell lines HEC1A and RL95-2 were used as experimental models for the non-receptive and receptive endometrium, respectively. Putative targets for activated steroid hormone receptors were investigated by chromatin immunoprecipitation (ChIP) using receptor-specific antibodies. Promoter occupancy of the selected genes by steroid receptors was detected in ChIP-purified DNA by quantitative PCR (qPCR). Expression analysis by reverse transcriptase (RT)-PCR was used to further investigate hormone dependent mRNA expression regulation of a subset of genes.</p> <p>Results</p> <p>ChIP-qPCR analysis demonstrated that each steroid hormone receptor had distinct group of target genes in the endometrial cell lines. After estradiol treatment, expression of estrogen receptor target genes predominated in HEC1A cells (n = 137) compared to RL95-2 cells (n = 35). In contrast, expression of progesterone receptor target genes was higher in RL95-2 cells (n = 83) than in HEC1A cells (n = 7) after progesterone treatment. RT-PCR analysis of 20 genes demonstrated transcriptional changes after estradiol or progesterone treatment of the cell lines.</p> <p>Conclusions</p> <p>Combined results from ChIP-qPCR and RT-PCR analysis showed different patterns of steroid hormone receptor occupancy at target genes, corresponding to activation or suppression of gene expression after hormone treatment of HEC1A and RL95-2 cell lines.</p