Beam-beam Blowup in the presence of x-y coupling sources at FCC-ee

FCC-ee, the lepton version of the Future Circular Collider (FCC), is a 100 Km future machine under study to be built at CERN. It acquires two experiments with a highest beam energy of 182.5 GeV. FCC-ee aims to operate at four different energies, with different luminosities to fulfil physics requirements. Beam-beam effects at such a high energy/luminosity machine are very challenging and require a deep understanding, especially in the presence of x-y coupling sources. Beam-beam effects include the beamstrahlung process, which limits the beam lifetime at high energies, as well as dynamic effects at the Interaction point (IP) which include changes in the beta functions and emittances. In this report, we will define the beam-beam effects and their behaviours in the FCC-ee highest energy lattice after introducing x-y coupling in the ring

MATERIAL WASTAGE ON CONSTRUCTION SITES IN THE GAZA STRIP

The Construction sector is one of the main contributors to the Palestinian economy and it is vital for necessary infrastructure development. The sector contributes up to 16 per cent of the GDP, employs approximately 22 per cent of the workforce and absorb up to 34 per cent of international donor programs. Waste has been considered to be a major problem in the Palestinian construction industry, and very little research has been conducted in this area in Palestine. The objective of this paper is to identify and rank the causes of material wastage in construction sites in the Gaza Strip. The research approach adopted in this study was questionnaire survey. Eighty valid questionnaires have been studied and analyzed. The results indicated that the main causes of material wastage are: poor performance leading to rework due to poor concrete placement, using longer steel bars than required, using low quality timbers, re

Ontological support for the evolution of future services oriented architectures

Services Oriented Architectures (SOA) have emerged as a useful framework for developing interoperable, large-scale systems, typically implemented using the Web Services (WS) standards. However, the maintenance and evolution of SOA systems present many challenges. SmartLife applications are intelligent user-centered systems and a special class of SOA systems that present even greater challenges for a software maintainer. Ontologies and ontological modeling can be used to support the evolution of SOA systems. This paper describes the development of a SOA evolution ontology and its use to develop an ontological model of a SOA system. The ontology is based on a standard SOA ontology. The ontological model can be used to provide semantic and visual support for software maintainers during routine maintenance tasks. We discuss a case study to illustrate this approach, as well as the strengths and limitations

Exposure-response modeling improves selection of radiation and radiosensitizer combinations

A central question in drug discovery is how to select drug candidates from a large number of available compounds. This analysis presents a model-based approach for comparing and ranking combinations of radiation and radiosensitizers. The approach is quantitative and based on the previously-derived Tumor Static Exposure (TSE) concept. Combinations of radiation and radiosensitizers are evaluated based on their ability to induce tumor regression relative to toxicity and other potential costs. The approach is presented in the form of a case study where the objective is to find the most promising candidate out of three radiosensitizing agents. Data from a xenograft study is described using a nonlinear mixed-effects modeling approach and a previously-published tumor model for radiation and radiosensitizing agents. First, the most promising candidate is chosen under the assumption that all compounds are equally toxic. The impact of toxicity in compound selection is then illustrated by assuming that one compound is more toxic than the others, leading to a different choice of candidate

Perturbation of Lytic and Latent Gammaherpesvirus Infection in the Absence of the Inhibitory Receptor CEACAM1

Control of gammaherpesvirus infections requires a complex, well orchestrated immune response regulated by positive and negative co-signaling molecules. While the impact of co-stimulatory molecules has been addressed in various studies, the role of co-inhibitory receptors has not been tested. The ITIM-bearing CEACAM1 is an inhibitory receptor expressed by a variety of immune cells, including B, T and NK cells. Using Ceacam1−/− mice, we analyzed the in vivo function of CEACAM1 during acute and latent murine gammaherpesvirus 68 (MHV-68) infection. During acute lytic replication, we observed lower virus titers in the lungs of Ceacam1−/− mice than in WT mice. In contrast, during latency amplification, Ceacam1−/− mice displayed increased splenomegaly and a higher latent viral load in the spleen. Analysis of the immune response revealed increased virus-specific antibody levels in Ceacam1−/− mice, while the magnitude of the T cell-mediated antiviral immune response was reduced. These findings suggest that inhibitory receptors can modulate the efficacy of immune responses against gammaherpesvirus infections