Lecture Notes on Network Information Theory

These lecture notes have been converted to a book titled Network Information Theory published recently by Cambridge University Press. This book provides a significantly expanded exposition of the material in the lecture notes as well as problems and bibliographic notes at the end of each chapter. The authors are currently preparing a set of slides based on the book that will be posted in the second half of 2012. More information about the book can be found at http://www.cambridge.org/9781107008731/. The previous (and obsolete) version of the lecture notes can be found at http://arxiv.org/abs/1001.3404v4/

On the Error Exponents of ARQ Channels with Deadlines

We consider communication over Automatic Repeat reQuest (ARQ) memoryless channels with deadlines. In particular, an upper bound L is imposed on the maximum number of ARQ transmission rounds. In this setup, it is shown that incremental redundancy ARQ outperforms Forney's memoryless decoding in terms of the achievable error exponents.Comment: 16 pages, 6 figures, Submitted to the IEEE Trans. on Information Theor

Synthesis and Reactivity of Acyclic (pentadienyl)iron(1+) Cations: Model Studies for the Preparation of the 8\u3cem\u3eE\u3c/em\u3e,10\u3cem\u3eZ\u3c/em\u3e,16\u3cem\u3eE\u3c/em\u3e,18\u3cem\u3eE\u3c/em\u3e-Tetraene Segment of Macrolactin A

The dicarbonyl(1,2-dimethylpentadienyl)triphenylphosphineiron(1+) cation (11) has been prepared from methyl 4-methyl-2E,4E-hexadienoate in four steps. The cation (11) reacts with hydride and carbon nucleophiles in a regiospecific fashion to afford (3-methyl-2E,4Z-diene)iron complexes. Dicarbonyl(3-methyl-7-nitro-2E,4Z-heptadiene)triphenylphosphineiron (15), the product from the reaction of 11 with nitromethane anion, has been utilized as a precursor for nitrile oxide–olefin cyclocondensations

An investigation of voids formation mechanisms and their effects on freeze and thaw processes of lithium and lithium fluoride

The mechanisms of void formation during the cooldown and freezing of lithium coolant within the primary loop of SP-100 type systems are investigated. These mechanisms are: (1) homogeneous nucleation; (2) heterogeneous nucleation; (3) normal segregation of helium gas dissolved in liquid lithium; and (4) shrinkage of lithium during freezing. To evaluate the void formation potential due to segregation, a numerical scheme that couples the freezing and mass diffusion processes in both the solid and liquid regions is developed. The results indicated that the formation of He bubbles is unlikely by either homogeneous or heterogeneous nucleation during the cooldown process. However, homogeneous nucleation of He bubbles following the segregation of dissolved He in liquid lithium ahead of the solid-liquid interface is likely to occur. Results also show that total volume of He void is insignificant when compared to that of shrinkage voids. In viewing this, the subsequent research focuses on the effects of shrinkage void forming during freezing of lithium on subsequent thaw processes are investigated using a numerical scheme that is based on a single (solid/liquid) cell approach. The cases of lithium-fluoride are also investigated to show the effect of larger volume shrinkage upon freezing on the freeze and thaw processes. Results show that a void forming at the wall appreciably reduces the solid-liquid interface velocity, during both freeze and thaw, and causes a substantial rise in the wall temperature during thaw. However, in the case of Li, the maximum wall temperature was much lower than the melting temperature of PWC-11, which is used as the structure material in the SP-100 system. Hence, it is included that a formation of hot spots is unlikely during the startup or restart of the SP-100 system

Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery.

Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa component of a large ventral skull base chondrosarcoma, arterial bleeding was encountered near the right internal carotid artery (ICA). Durable hemostasis could not be achieved with packing and the patient was taken for an emergent angiogram that revealed a pseudoaneurysm of the proximal intradural ICA. Given the presence of good collateral flow through the anterior and posterior communicating arteries, the right ICA was sacrificed by coil embolization. The patient was taken back to the operating room for closure then transferred to the intensive care unit and maintained on vasopressors for five days to ensure adequate perfusion. The right ICA was coil embolized and the patient was taken back to the operating room for closure. The patient recovered without complication. Arterial injuries, although serious, are not always catastrophic. Critical steps are immediate recognition of bleeding, vascular imaging, and vessel sacrifice if necessary

Wyner VAE: Joint and Conditional Generation with Succinct Common Representation Learning

A new variational autoencoder (VAE) model is proposed that learns a succinct common representation of two correlated data variables for conditional and joint generation tasks. The proposed Wyner VAE model is based on two information theoretic problems---distributed simulation and channel synthesis---in which Wyner's common information arises as the fundamental limit of the succinctness of the common representation. The Wyner VAE decomposes a pair of correlated data variables into their common representation (e.g., a shared concept) and local representations that capture the remaining randomness (e.g., texture and style) in respective data variables by imposing the mutual information between the data variables and the common representation as a regularization term. The utility of the proposed approach is demonstrated through experiments for joint and conditional generation with and without style control using synthetic data and real images. Experimental results show that learning a succinct common representation achieves better generative performance and that the proposed model outperforms existing VAE variants and the variational information bottleneck method.Comment: 24 pages, 18 figure

Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.

While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediated immunity by targeting immune-checkpoint pathways, robust responses are uncommon. Augmenting tumor antigen-specific immune responses by endogenous dendritic cells (DCs) is appealing from a specificity standpoint, but challenging. Here, we show that restricting a heparan sulfate (HS) loss-of-function mutation in the HS sulfating enzyme Ndst1 to predominantly conventional DCs (Ndst1f/f CD11cCre+ mutation) results in marked inhibition of Lewis lung carcinoma growth along with increased tumor-associated CD8+ T cells. In mice deficient in a major DC HS proteoglycan (syndecan-4), splenic CD8+ T cells showed increased anti-tumor cytotoxic responses relative to controls. Studies examining Ndst1f/f CD11cCre + mutants revealed that mutation was associated with an increase in anti-tumor cytolysis using either splenic CD8+ T cells or tumor-infiltrating (TIL) CD8+ T cells purified ex-vivo, and tested in pooled effector-to-target cytolytic assays against tumor cells from respective animals. On glycan compositional analysis, HS purified from Ndst1f/f CD11cCre + mutant DCs had reduced overall sulfation, including reduced sulfation of a tri-sulfated disaccharide species that was intriguingly abundant on wildtype DC HS. Interestingly, antigen presentation in the context of major histocompatibility complex class-I (MHC-I) was enhanced in mutant DCs, with more striking effects in the setting of HS under-sulfation, pointing to a likely regulatory role by sulfated glycans at the antigen/MHC-I - T-cell interface; and possibly future opportunities to improve antigen-specific T cell responses by immunologic targeting of HS proteoglycans in cancer