Second Trimeter Recurrent Pregnancy Loss in Women with History of PCOS

Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine because the etiology is often unknown. Hyper insulinemia ascribed to PCOS and insulin resistance (IR) seem to be a contributing factor to RPL.&nbsp;The aim of this study was to assess the relationship between serum homocysteine level and insulin resistance in PCOS women with a history of send trimester recurrent pregnancy loss.The present study was carried out on 100 non-pregnant women in the reproductive period; their age ranged from 20 to 35 years. They were classified under two groups: Group 1: women having a history of second trimester recurrent pregnancy loss with PCOs (60 women). Group 2: women having a history of second trimester recurrent pregnancy loss and non-PCOs (40 women).&nbsp;We assessed plasma insulin and homocysteine (Hcy) levels in all cases. In addition, insulin resistance was determined using homeostasis model assessment (HOMA2-IR).&nbsp;The results: We found that homocysteine and insulin resistance are higher in PCOS women with recurrent pregnancy loss than non PCOS women.&nbsp;Conclusion: We conclude that that women with PCOS having a history of recurrent pregnancy loss had a higher serum level of homocysteine and a higher score of HOMA2-IR women without PCOS.</p