SYSGENET: a meeting report from a new European network for systems genetics

The first scientific meeting of the newly established European SYSGENET network took place at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, April 7-9, 2010. About 50 researchers working in the field of systems genetics using mouse genetic reference populations (GRP) participated in the meeting and exchanged their results, phenotyping approaches, and data analysis tools for studying systems genetics. In addition, the future of GRP resources and phenotyping in Europe was discussed

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

Genetic determinants of cognition are poorly characterized, and their relationship to genes that confer risk for neurodevelopmental disease is unclear. Here we performed a systems-level analysis of genome-wide gene expression data to infer gene-regulatory networks conserved across species and brain regions. Two of these networks, M1 and M3, showed replicable enrichment for common genetic variants underlying healthy human cognitive abilities, including memory. Using exome sequence data from 6,871 trios, we found that M3 genes were also enriched for mutations ascertained from patients with neurodevelopmental disease generally, and intellectual disability and epileptic encephalopathy in particular. M3 consists of 150 genes whose expression is tightly developmentally regulated, but which are collectively poorly annotated for known functional pathways. These results illustrate how systems-level analyses can reveal previously unappreciated relationships between neurodevelopmental disease–associated genes in the developed human brain, and provide empirical support for a convergent gene-regulatory network influencing cognition and neurodevelopmental disease

A mixed seismic–aseismic stress release episode in the Andean subduction zone

International audienceIn subduction zones, stress is released by earthquakes and transient aseismic slip. The latter falls into two categories: slow slip and afterslip. Slow-slip events emerge spontaneously during the interseismic phase, and show a progressive acceleration of slip with a negligible contribution of synchronous tremors or microseismicity to the energy, or moment release1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12. In contrast, afterslip occurs immediately after large and moderate earthquakes, decelerates over time, and releases between 20 and 400% of the moment released by the preceding earthquake13, 14, 15, 16, 17, 18. Here we use seismic and GPS data to identify transient aseismic slip that does not fit into either of these categories. We document a seismic–aseismic slip sequence which occurred at shallow depths along a weakly coupled part of the Andean subduction zone19 in northern Peru and lasted seven months. The sequence generated several moderate earthquakes that together account for about 25% of the total moment released during the full sequence, equivalent to magnitude 6.7. Transient slip immediately followed two of the earthquakes, with slip slowing at a logarithmic rate. Considered separately, the moment released by transient slip following the second earthquake was more than 1,000% of the moment released during the earthquake itself, a value incompatible with classical models of afterslip. Synchronous seismic swarms and aseismic slip may therefore define a stress-release process that is distinct from slow-slip events and afterslip