The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers

This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SMI35, R=0.44, P=0.016). The degree of neurofilament phosphorylation (ratio NfH-SMI34 to NfH-SMI35) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P=0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS

Effect of muscle temperature soon after slaughter on pork quality: a pilot study.

The effect of various environmental temperatures, ranging between 42.5 and 25 degrees C during the first 2 h after slaughter, on pork quality was studied in longissimus dorsi samples. Higher environmental temperatures resulted in higher lactate and lower pH 2 h after slaughter. Samples kept at higher environmental temperatures (42.5 and 40 degrees C) showed characteristics typical for pale soft exudative pork. (Abstract retrieved from CAB Abstracts by CABI’s permission

THE Effect of a single locus (Halothane) on variances of and correlations among quantitative production traits

International audienc

Halothane-test in pig breeding

International audienc

Production characteristics of dutch landrace and dutch yorkshire pigs as related to their susceptibility for the halothane-induced malignant hyperthermia syndrome

International audienc

Voeronthouding voor aflevering

Het vasten van vleesvarkens voor aflevering kan de kwaliteit van het vlees verbeteren. Bij vasten langer dan 18 uur lijkt tevens het vleespercentage iets hoger

Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease

Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer’s disease (AD). In this study, we demonstrate that AGE-albumin, the most abundant AGE product in human AD brains, is synthesized in activated microglial cells and secreted into the extracellular space. The rate of AGE-albumin synthesis in human microglial cells is markedly increased by amyloid-β exposure and oxidative stress. Exogenous AGE-albumin upregulates the receptor protein for AGE (RAGE) and augments calcium influx, leading to apoptosis of human primary neurons. In animal experiments, soluble RAGE (sRAGE), pyridoxamine or ALT-711 prevented Aβ-induced neuronal death in rat brains. Collectively, these results provide evidence for a new mechanism by which microglial cells promote death of neuronal cells through synthesis and secretion of AGE-albumin, thereby likely contributing to neurodegenerative diseases such as AD