20 research outputs found
Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance
The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers
The Fatigue Threshold of Rubber and Its Characterization Using the Cutting Method
Below a limiting value of tearing energy called the intrinsic strength or fatigue threshold (T-0), cracks will not grow in rubber due to fatigue; hence, this material characteristic is important to understand from both fundamental and practical perspectives. We summarize key aspects of the fatigue threshold, including the Lake-Thomas molecular interpretation of T-0 in terms of fracture of polymer network chains in crosslinked elastomers. The various testing approaches for quantifying T-0 are also discussed, with a focus on the classic Lake-Yeoh cutting method which was recently revived by the introduction of a commercial testing instrument that applies this procedure, the Intrinsic Strength Analyser (ISA). A validation of the cutting method is also given by demonstrating that a 2-h test on the ISA yields a value of T-0 that is essentially identical to the T-0 from near-threshold fatigue crack growth (FCG) measurements that require 7.5 months of continuous testing. Compound formulation effects - polymer type, crosslink density, type and amount of reinforcing fillers, and addition of oils/plasticizers - are examined based on the limited published research in this area and our new results. At the end, some insights are offered into using the fatigue threshold to develop highly durable rubber products.Ministry of Education, Youth and Sports of the Czech Republic - DKRVO [RP/CPS/2020/004
From Sensations to Concepts: a Proposal for Two Learning Processes
This article presents two learning processes in order to explain how children at an early age can transform a complex sensory input to concepts and categories. The first process constructs the perceptual structures that emerge in children’s cognitive development by detecting invariants in the sensory input. The invariant structures involve a reduction in dimensionality of the sensory information. It is argued that this process generates the primary domains of space, objects and actions and that these domains can be represented as conceptual spaces. Once the primary domains have been established, the second process utilizes covariances between different dimensions of the domains in order to identify natural clusters of entities. The clusters are then are used to determine concepts as regions in the spaces. As an application, the processes are used to resolve the so-called ‘complex first paradox’ that emerges from the fact that children, in general, learn nouns earlier than adjectives, even though nouns are semantically more complex than adjectives