Inferring Unusual Crowd Events From Mobile Phone Call Detail Records

The pervasiveness and availability of mobile phone data offer the opportunity of discovering usable knowledge about crowd behaviors in urban environments. Cities can leverage such knowledge in order to provide better services (e.g., public transport planning, optimized resource allocation) and safer cities. Call Detail Record (CDR) data represents a practical data source to detect and monitor unusual events considering the high level of mobile phone penetration, compared with GPS equipped and open devices. In this paper, we provide a methodology that is able to detect unusual events from CDR data that typically has low accuracy in terms of space and time resolution. Moreover, we introduce a concept of unusual event that involves a large amount of people who expose an unusual mobility behavior. Our careful consideration of the issues that come from coarse-grained CDR data ultimately leads to a completely general framework that can detect unusual crowd events from CDR data effectively and efficiently. Through extensive experiments on real-world CDR data for a large city in Africa, we demonstrate that our method can detect unusual events with 16% higher recall and over 10 times higher precision, compared to state-of-the-art methods. We implement a visual analytics prototype system to help end users analyze detected unusual crowd events to best suit different application scenarios. To the best of our knowledge, this is the first work on the detection of unusual events from CDR data with considerations of its temporal and spatial sparseness and distinction between user unusual activities and daily routines.Comment: 18 pages, 6 figure

Room-Temperature operation of a quantum well mid-infrared detector embedded in nano-antennae array at critical optical coupling

We present the first room temperature photodection of hundreds on nanowatts using a quantum well mid-infrared detector at 9μm, with a background-limited temperature of 82K and a corresponding background-limited specific detectivity of 1.4×1010 cmHz1/2/W. The photonic architecture consists of an array of double metal nano-antennae and allows to reduce the dark current and increase the absorbed electromagnetic field inside the active region, so to prove a high temperature photoresponse

Relative entanglement entropies in 1 + 1-dimensional conformal field theories

We study the relative entanglement entropies of one interval between excited states of a 1+1 dimensional conformal field theory (CFT). To compute the relative entropy S(\u3c11\u2016\u3c10) between two given reduced density matrices \u3c11 and \u3c10 of a quantum field theory, we employ the replica trick which relies on the path integral representation of Tr(\u3c11\u3c1n 1210) and define a set of R\'enyi relative entropies Sn(\u3c11\u2016\u3c10). We compute these quantities for integer values of the parameter n and derive via the replica limit, the relative entropy between excited states generated by primary fields of a free massless bosonic field. In particular, we provide the relative entanglement entropy of the state described by the primary operator i 02\u3d5, both with respect to the ground state and to the state generated by chiral vertex operators. These predictions are tested against exact numerical calculations in the XX spin-chain finding perfect agreement. \ua9 2017, The Author(s)

Light-cone-like spreading of correlations in a quantum many-body system

How fast can correlations spread in a quantum many-body system? Based on the seminal work by Lieb and Robinson, it has recently been shown that several interacting many-body systems exhibit an effective light cone that bounds the propagation speed of correlations. The existence of such a "speed of light" has profound implications for condensed matter physics and quantum information, but has never been observed experimentally. Here we report on the time-resolved detection of propagating correlations in an interacting quantum many-body system. By quenching a one-dimensional quantum gas in an optical lattice, we reveal how quasiparticle pairs transport correlations with a finite velocity across the system, resulting in an effective light cone for the quantum dynamics. Our results open important perspectives for understanding relaxation of closed quantum systems far from equilibrium as well as for engineering efficient quantum channels necessary for fast quantum computations.Comment: 7 pages, 5 figures, 2 table

Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity

BACKGROUND: It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug being developed for the treatment of rheumatoid arthritis (RA), a U-shaped dose response curve was observed. In the light of this result further research was undertaken to design an efficient phase 2a proof of concept (PoC) trial for a follow-on compound using the lessons learnt from the lead compound. METHODS: The planned analysis for the Phase 2a trial for GSK123456 was a Bayesian Emax model which assumes the dose-response relationship follows a monotonic sigmoid "S" shaped curve. This model was found to be suboptimal to model the U-shaped dose response observed in the data from this trial and alternatives approaches were needed to be considered for the next compound for which a Normal dynamic linear model (NDLM) is proposed. This paper compares the statistical properties of the Bayesian Emax model and NDLM model and both models are evaluated using simulation in the context of adaptive Phase 2a PoC design under a variety of assumed dose response curves: linear, Emax model, U-shaped model, and flat response. RESULTS: It is shown that the NDLM method is flexible and can handle a wide variety of dose-responses, including monotonic and non-monotonic relationships. In comparison to the NDLM model the Emax model excelled with higher probability of selecting ED90 and smaller average sample size, when the true dose response followed Emax like curve. In addition, the type I error, probability of incorrectly concluding a drug may work when it does not, is inflated with the Bayesian NDLM model in all scenarios which would represent a development risk to pharmaceutical company. The bias, which is the difference between the estimated effect from the Emax and NDLM models and the simulated value, is comparable if the true dose response follows a placebo like curve, an Emax like curve, or log linear shape curve under fixed dose allocation, no adaptive allocation, half adaptive and adaptive scenarios. The bias though is significantly increased for the Emax model if the true dose response follows a U-shaped curve. CONCLUSIONS: In most cases the Bayesian Emax model works effectively and efficiently, with low bias and good probability of success in case of monotonic dose response. However, if there is a belief that the dose response could be non-monotonic then the NDLM is the superior model to assess the dose response

Dynamics of a Quantum Phase Transition and Relaxation to a Steady State

We review recent theoretical work on two closely related issues: excitation of an isolated quantum condensed matter system driven adiabatically across a continuous quantum phase transition or a gapless phase, and apparent relaxation of an excited system after a sudden quench of a parameter in its Hamiltonian. Accordingly the review is divided into two parts. The first part revolves around a quantum version of the Kibble-Zurek mechanism including also phenomena that go beyond this simple paradigm. What they have in common is that excitation of a gapless many-body system scales with a power of the driving rate. The second part attempts a systematic presentation of recent results and conjectures on apparent relaxation of a pure state of an isolated quantum many-body system after its excitation by a sudden quench. This research is motivated in part by recent experimental developments in the physics of ultracold atoms with potential applications in the adiabatic quantum state preparation and quantum computation.Comment: 117 pages; review accepted in Advances in Physic

Room-temperature nine-µm-wavelength photodetectors and GHz-frequency heterodyne receivers

Room-temperature operation is essential for any optoelectronics technology that aims to provide low-cost, compact systems for widespread applications. A recent technological advance in this direction is bolometric detection for thermal imaging¹, which has achieved relatively high sensitivity and video rates (about 60 hertz) at room temperature. However, owing to thermally induced dark current, room-temperature operation is still a great challenge for semiconductor photodetectors targeting the wavelength band between 8 and 12 micrometres², and all relevant applications, such as imaging, environmental remote sensing and laser-based free-space communication³,⁴,⁵, have been realized at low temperatures. For these devices, high sensitivity and high speed have never been compatible with high-temperature operation⁶,⁷. Here we show that a long-wavelength (nine micrometres) infrared quantum-well photodetector⁸ fabricated from a metamaterial made of sub-wavelength metallic resonators⁹,¹⁰,¹¹,¹² exhibits strongly enhanced performance with respect to the state of the art up to room temperature. This occurs because the photonic collection area of each resonator is much larger than its electrical area, thus substantially reducing the dark current of the device¹³. Furthermore, we show that our photonic architecture overcomes intrinsic limitations of the material, such as the drop of the electronic drift velocity with temperature¹⁴,¹⁵, which constrains conventional geometries at cryogenic operation⁶. Finally, the reduced physical area of the device and its increased responsivity allow us to take advantage of the intrinsic high-frequency response of the quantum detector⁷ at room temperature. By mixing the frequencies of two quantum-cascade lasers¹⁶ on the detector, which acts as a heterodyne receiver, we have measured a high-frequency signal, above four gigahertz (GHz). Therefore, these wide-band uncooled detectors could benefit technologies such as high-speed (gigabits per second) multichannel coherent data transfer¹⁷ and high-precision molecular spectroscopy¹⁸

Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Little is known about airway remodelling in bronchial biopsies (BB) in smokers and chronic obstructive pulmonary disease (COPD). We conducted an initial pilot study comparing BB from COPD patients with nonsmoking controls. This pilot study suggested the presence of reticular basement membrane (Rbm) fragmentation and altered vessel distribution in COPD.</p> <p>Methods</p> <p>To determine whether Rbm fragmentation and altered vessel distribution in BB were specific for COPD we designed a cross-sectional study and stained BB from 19 current smokers and 14 ex-smokers with mild to moderate COPD and compared these to 15 current smokers with normal lung function and 17 healthy and nonsmoking subjects.</p> <p>Results</p> <p>Thickness of the Rbm was not significantly different between groups; although in COPD this parameter was quite variable. The Rbm showed fragmentation and splitting in both current smoking groups and ex-smoker COPD compared with healthy nonsmokers (p < 0.02); smoking and COPD seemed to have additive effects. Rbm fragmentation correlated with smoking history in COPD but not with age. There were more vessels in the Rbm and fewer vessels in the lamina propria in current smokers compared to healthy nonsmokers (p < 0.05). The number of vessels staining for vascular endothelial growth factor (VEGF) in the Rbm was higher in both current smoker groups and ex-smoker COPD compared to healthy nonsmokers (p < 0.004). In current smoker COPD VEGF vessel staining correlated with FEV1% predicted (r = 0.61, p < 0.02).</p> <p>Conclusions</p> <p>Airway remodelling in smokers and mild to moderate COPD is associated with fragmentation of the Rbm and altered distribution of vessels in the airway wall. Rbm fragmentation was also present to as great an extent in ex-smokers with COPD. These characteristics may have potential physiological consequences.</p

Corner contributions to holographic entanglement entropy in AdS4/BCFT3

We study the holographic entanglement entropy of spatial regions with corners in the AdS4/BCFT3correspondence by considering three dimensional boundary conformal field theories whose boundary is a timelike plane. We compute analytically the corner function corresponding to an infinite wedge having one edge on the boundary. A relation between this corner function and the holographic one point function of the stress tensor is observed. An analytic expression for the corner function of an infinite wedge having only its tip on the boundary is also provided. This formula requires to find the global minimum among two extrema of the area functional. The corresponding critical configurations of corners are studied. The results have been checked against a numerical analysis performed by computing the area of the minimal surfaces anchored to some finite domains containing corners

On shape dependence of holographic entanglement entropy in AdS4/CFT3

We study the finite term of the holographic entanglement entropy of finite domains with smooth shapes and for four dimensional gravitational backgrounds. Analytic expressions depending on the unit vectors normal to the minimal area surface are obtained for both stationary and time dependent spacetimes. The special cases of AdS4, asymptotically AdS4 black holes, domain wall geometries and Vaidya-AdS backgrounds have been analysed explicitly. When the bulk spacetime is AdS4, the finite term is the Willmore energy of the minimal area surface viewed as a submanifold of the three dimensional flat Euclidean space. For the static spacetimes, some numerical checks involving spatial regions delimited by ellipses and non convex domains have been performed. In the case of AdS4, the infinite wedge has been also considered, recovering the known analytic formula for the coefficient of the logarithmic divergence