Dystroglycan versatility in cell adhesion: a tale of multiple motifs

Dystroglycan is a ubiquitously expressed heterodimeric adhesion receptor. The extracellular a-subunit makes connections with a number of laminin G domain ligands including laminins, agrin and perlecan in the extracellular matrix and the transmembrane b-subunit makes connections to the actin filament network via cytoskeletal linkers including dystrophin, utrophin, ezrin and plectin, depending on context. Originally discovered as part of the dystrophin glycoprotein complex of skeletal muscle, dystroglycan is an important adhesion molecule and signalling scaffold in a multitude of cell types and tissues and is involved in several diseases. Dystroglycan has emerged as a multifunctional adhesion platform with many interacting partners associating with its short unstructured cytoplasmic domain. Two particular hotspots are the cytoplasmic juxtamembrane region and at the very carboxy terminus of dystroglycan. Regions which between them have several overlapping functions: in the juxtamembrane region; a nuclear localisation signal, ezrin/radixin/moesin protein, rapsyn and ERK MAP Kinase binding function, and at the C terminus a regulatory tyrosine governing WW, SH2 and SH3 domain interactions. We will discuss the binding partners for these motifs and how their interactions and regulation can modulate the involvement of dystroglycan in a range of different adhesion structures and functions depending on context. Thus dystroglycan presents as a multifunctional scaffold involved in adhesion and adhesion-mediated signalling with its functions under exquisite spatiotemporal regulation

Alberta Occupational Medicine Newsletter: Spring 1986

Editorial Comments -- PCB's: An Overview -- Rash Statements - 8 -- Upcoming Events -- Challenges in Occupational Health and Safety -- Publications on Guidelines from Alberta Worker's Health, Safety and Compensation -- Studies of Occupational Cancer -- Using Mortality Records and Cancer Registrations -- Carpal Tunnel Syndrome - Etiology and Pathogenesis - 'State of the Art

Marital Adjustment

The definition of this construct is one of the most controversial topics in the literature. On the basis of various contributions, marital adjustment can be defined as a multidimensional indicator of the quality of marital relationship. Evolution of the Construct Marital adjustment is one of the most studied dimensions in the couple and family research literature. According to Spanier (1976, p. 15), already by the 1970s, marital adjustment was \u201cprobably the most frequently investigated dependent variable in the field\u201d. Also during the last 30 years, family researchers and scholars have maintained a strong interest on marital adjustment, as an outcome (Shriner 2009). The literature on marital adjustment reveals a variety of factors that are related to the dyadic adjustment (e.g., individual aspects like personality traits, irrational beliefs, and dysfunctional emotions Abbasi 2017; Filipovi\u107 et al. 2016 and relational aspects like romantic attachment and dyadic coping (Young et al. 2017). Over the last decade, a substantial number of studies have focused on the role of personality traits in predicting the quality of adult romantic relationships (Abbasi 2017; Lampis et al. 2018; Rusu et al. 2019)