Suivi expérimental et modélisation des flux d'eau et de solutés dans le système sol-plante: application à des questions agro-environnementales

Root-soil interactions are multiple: • Root growth is affected by soil structure // generates soil structure (C cycle, rhizosphere, compaction,…) • Roots regulate water transpiration streamin interactions with stomatas (stress, ABA, soilmoisture availibility,…) => impact crop yield • Roots define and change the rhizosphere properties and are affected by it • Root system is themain entry for nutrient/pesticide/ • Affects solute transport and water flow in soil -> groundwater quality and quantity Numerous (nonlinear) processes /complex behavio

Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR

As cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR

A game theory modeling approach for 3G operators

Technoeconomics, Techno-economics, Game theory, NPV, Investment UMTS, 3G, Market conditions, Telecommunications,