5 research outputs found
Assessment of future climate change impacts on snowmelt and stream water quality for a mountainous high-elevation watershed using SWAT
Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens
Biochemical profile and bioactive potential of thirteen wild folk medicinal plants from Balochistan, Pakistan
Differentially Expressed Genes during Flowering and Grain Filling in Common Bean (Phaseolus vulgaris) Grown under Drought Stress Conditions
Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry
Objective. Digital ulcers (DUs) are frequent manifestations of systemic
scleroderma (SSc). This study assessed functional limitations due to DUs
among patients enrolled in the Digital Ulcer Outcome (DUO) Registry, an
international, multicentre, observational registry of SSc patients with
DU disease.
Methods. Patients completed at enrolment a DU-specific functional
assessment questionnaire with a 1-month recall period, measuring
impairment in work and daily activities, and hours of help needed from
others. Physician-reported clinical parameters were used to describe the
population. For patients who completed at least part of the
questionnaire, descriptive analyses were performed for overall results,
and stratified by number of DUs at enrolment.
Results. This study included 2327 patients who completed at least part
of the questionnaire. For patients with 0, 1-2, and DUs at enrolment,
mean overall work impairment during the prior month among
employed/self-employed patients was 28\%, 42\%, and 48\%, respectively.
Across all included patients, ability to perform daily activities was
impaired on average by 35\%, 54\%, and 63\%, respectively. Patients
required a mean of 2.0, 8.7, and 8.8 hours of paid help and 17.0, 35.9,
and 63.7 hours of unpaid help, respectively, due to DUs in the prior
month. Patients with DUs had more complications and medication use than
patients with no DUs.
Conclusion. With increasing number of DUs, SSc patients reported more
impairment in work and daily activities and required more support from
others