A pentagonal cyanostar macrocycle with cyanostilbene CH donors binds anions and forms dialkylphosphate [3]rotaxanes

Since the discovery of crown ethers, macrocycles have been recognized as powerful platforms for supramolecular chemistry. Although their numbers and variations are now legion, macrocycles that are simple to make using high-yielding reactions in one pot and on the multigram scale are rare. Here we present such a discovery obtained during the creation of a C 5 -symmetric cyanostilbene \u27campestarene\u27 macrocycle, cyanostar, that employs Knoevenagel condensations in the preparation of its cyanostilbene repeat unit. In the solid state, cyanostars form π-stacked dimers constituted of chiral P and M enantiomers. The electropositive central cavity stabilizes anions with CH hydrogen-bonding units that are activated by electron-withdrawing cyano groups. In solution, the cyanostar shows high-affinity binding as 2:1 sandwich complexes, log β 2 ≈ 12 and ΔG ≈ -70 kJ mol -1, of large anions (BF 4 -, ClO 4 - and PF 6 -) usually considered weakly coordinating. The cyanostar\u27s size preference allowed formation of an unprecedented [3]rotaxane templated around a dialkylphosphate. © 2013 Macmillan Publishers Limited. All rights reserved

Reference values for generic instruments used in routine outcome monitoring: the leiden routine outcome monitoring study

<p>Abstract</p> <p>Introduction</p> <p>The Brief Symptom Inventory (BSI), Mood & Anxiety Symptom Questionnaire −30 (MASQ-D30), Short Form Health Survey 36 (SF-36), and Dimensional Assessment of Personality Pathology-Short Form (DAPP-SF) are generic instruments that can be used in Routine Outcome Monitoring (ROM) of patients with common mental disorders. We aimed to generate reference values usually encountered in 'healthy' and ‘psychiatrically ill’ populations to facilitate correct interpretation of ROM results.</p> <p>Methods</p> <p>We included the following specific reference populations: 1294 subjects from the general population (ROM reference group) recruited through general practitioners, and 5269 psychiatric outpatients diagnosed with mood, anxiety, or somatoform (MAS) disorders (ROM patient group). The outermost 5% of observations were used to define limits for one-sided reference intervals (95^th percentiles for BSI, MASQ-D30 and DAPP-SF, and 5^th percentiles for SF-36 subscales). Internal consistency and Receiver Operating Characteristics (ROC) analyses were performed.</p> <p>Results</p> <p>Mean age for the ROM reference group was 40.3 years (SD=12.6) and 37.7 years (SD=12.0) for the ROM patient group. The proportion of females was 62.8% and 64.6%, respectively. The mean for cut-off values of healthy individuals was 0.82 for the BSI subscales, 23 for the three MASQ-D30 subscales, 45 for the SF-36 subscales, and 3.1 for the DAPP-SF subscales. Discriminative power of the BSI, MASQ-D30 and SF-36 was good, but it was poor for the DAPP-SF. For all instruments, the internal consistency of the subscales ranged from adequate to excellent.</p> <p>Discussion and conclusion</p> <p>Reference values for the clinical interpretation were provided for the BSI, MASQ-D30, SF-36, and DAPP-SF. Clinical information aided by ROM data may represent the best means to appraise the clinical state of psychiatric outpatients.</p