Cis-regulatory basis of sister cell type divergence in the vertebrate retina

Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood. Here, we study a canonical pair of sister cell types, retinal photoreceptors and bipolar cells, to identify the ke

From Majorana theory of atomic autoionization to Feshbach resonances in high temperature superconductors

The Ettore Majorana paper - Theory of incomplete P triplets- published in 1931, focuses on the role of selection rules for the non-radiative decay of two electron excitations in atomic spectra, involving the configuration interaction between discrete and continuum channels. This work is a key step for understanding the 1935 work of Ugo Fano on the asymmetric lineshape of two electron excitations and the 1958 Herman Feshbach paper on the shape resonances in nuclear scattering arising from configuration interaction between many different scattering channels. The Feshbach resonances are today of high scientific interest in many different fields and in particular for ultracold gases and high Tc superconductivity.Comment: 13 pages, 7 figures. Journal of Superconductivity and Novel Magnetism to be publishe

The discoveries of uranium 237 and symmetric fission — From the archival papers of Nishina and Kimura

Shortly before the Second World War time, Nishina reported on a series of prominent nuclear physical and radiochemical studies in collaboration with Kimura. They artificially produced 231Th, a member of the natural actinium series of nuclides, by bombarding thorium with fast neutrons. This resulted in the discovery of 237U, a new isotope of uranium, by bombarding uranium with fast neutrons, and confirmed that 237U disintegrates into element 93 with a mass number of 237. They also identified the isotopes of several middle-weighted elements produced by the symmetric fission of uranium. In this review article, the highlights of their work are briefly summarized along with some explanatory commentaries

The Immune Landscape of Cancer

We performed an extensive immunogenomic anal-ysis of more than 10,000 tumors comprising 33diverse cancer types by utilizing data compiled byTCGA. Across cancer types, we identified six im-mune subtypes\u2014wound healing, IFN-gdominant,inflammatory, lymphocyte depleted, immunologi-cally quiet, and TGF-bdominant\u2014characterized bydifferences in macrophage or lymphocyte signa-tures, Th1:Th2 cell ratio, extent of intratumoral het-erogeneity, aneuploidy, extent of neoantigen load,overall cell proliferation, expression of immunomod-ulatory genes, and prognosis. Specific drivermutations correlated with lower (CTNNB1,NRAS,orIDH1) or higher (BRAF,TP53,orCASP8) leukocytelevels across all cancers. Multiple control modalitiesof the intracellular and extracellular networks (tran-scription, microRNAs, copy number, and epigeneticprocesses) were involved in tumor-immune cell inter-actions, both across and within immune subtypes.Our immunogenomics pipeline to characterize theseheterogeneous tumors and the resulting data areintended to serve as a resource for future targetedstudies to further advance the field

Basic Research and Particle Accelerators

This report addresses the basic research and particle accelerators

CRADA Final Report CRADA No. LB05-001820"Ion Beam Drift Compression Technology for NDCX"

Summary of the specific research and project accomplishments: Through this collaboration, LBNL and FPSI determined the specific energy manipulations that apply to the Neutralized Drift Compression Experiment (NDCX) ion beam and developed the preliminary design of a Fast Induction Energy Corrector (FIEC). This effort was successfully completed, firmly establishing the technical feasibility of the proposed approach for regulating the longitudinal energy distribution of the NDCX ion beam. This is a critical step in achieving the NDCX goal of axial compression of the beam by a factor of 100 during neutralized drift

Chemical composition, feed intakes and digestibilities of crop residue-based rations in non-lactating Red Sokoto goats in the sub-humid zone of Nigeria

The present study was conducted to evaluate the chemical composition, intake and digestibility of crop residue based rations by Red Sokoto goats maintained on natural pastures and Digitaria smutsii hay during the dry season of the year. Twenty-eight non-lactating does were blocked for weight and assigned to 7 treatment groups comprising 4 does each in a completely randomized design. Ration A, the conventional concentrate ration, was used as the positive control, Rations B and C were the two crop residue based test rations, while Ration D, the unsupplemented treatment, was used as the negative control. Each of the supplementation rations was fed at 1% and 2% of the doe's body weight. Ration A had the highest crude protein percentage of 17.19% while Rations B and C had 9.54 and 10.38%, respectively. The naturally grazed pastures and Digitaria smutsii hay (Ration D) contained the least protein: 2.76 and 4.75%, respectively. Ration D also had the highest percentages of acid detergent fiber, neutral detergent fiber and lignin (49.14, 74.73 and 9.49% in hay and 50.29, 8.27 and 11.5% in grazed pastures, respectively). Ration A on the other hand, had the lowest percentages of acid detergent fiber (20.00%), neutral detergent fiber (40.01%) and lignin (4.64%). The results indicated that the supplemented group of does had significantly higher (P < 0.05) dry matter and crude protein intakes as well as nutrient digestibilities than the unsupplemented groups. A comparison of the unsupplemented animals with all the other treatment groups revealed that dry matter digestibility improved by a range of 4.1–27.9%, while crude protein digestibility improved by 17.1–42.2%, the highest value being in does on Ration A. It was concluded that goats were able to subsist and make appreciable gains in the long dry season on crop-based diets that compared favorably with the conventional concentrate rations. Of the two tested crop residue based rations, Ration C is a better supplementation package than Ration B