America's Turning Point: The 2016 Elections with E.J. Dionne

The 2016 presidential election may offer the sharpest divide since Barry Goldwater squared off against Lyndon Johnson in 1964. How did we get here and what are the stakes in the outcome of the fall election? This event is moderated by Professor Larry Jacobs.Center for the Study of Politics and Governance, Humphrey School of Public Affairs, UM

Personalised immunotherapy in sepsis: a scoping review protocol

INTRODUCTION: Sepsis, a life-threatening organ dysfunction syndrome occurring in the context of severe infections, remains a major burden on global health with high morbidity and high mortality rates. Despite recent advances in the understanding of its pathophysiology, the treatment of sepsis remains supportive of nature with few interventions specifically designed for treating this complex syndrome. The focus of sepsis trials has increasingly shifted towards targeting excessive inflammation and immunosuppression using immunomodulatory agents. However, it remains uncertain how to identify patients that could benefit from such treatment, whether treatments can be tailored to an individual's immune profile, or at which stage of the disease the intervention should be initiated. In this scoping review, we provide a comprehensive overview of current available literature on immunostimulatory and immunosuppressive therapies against sepsis. METHODS AND ANALYSIS: The aim of this scoping review is to describe and summarise current literature evaluating immunotherapy in adult patients with sepsis. The review will be performed using the framework formulated by Arksey and O'Malley. A comprehensive literature and study collection will be executed by searching PubMed, Embase, Cochrane CENTRAL and ClinicalTrials.gov to identify clinical trials and cohort studies concerning immunotherapy in adult patients with sepsis. Screening will be performed independently and in duplicate by two reviewers who will also independently extract data into prespecified spreadsheets. We will summarise evidence in tabular format with descriptive statistics. The reported evidence will convey knowledge on the types of immunotherapies studied, and currently being studied, in adult patients with sepsis. ETHICS AND DISSEMINATION: Approval from a medical ethics committee is not required. Once completed, the review will be submitted for publication in a peer-reviewed journal. These results will be of value to clinicians and researchers with an interest in advancing sepsis care. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ

THE SUCCESS of the 1993 BUDGET RECONCILIATION BILL at REDUCING the FEDERAL BUDGET DEFICIT

This article discusses the process by which President Clinton achieved a budgetdeficit reduction package in Congress and the implications of this process. It concludes that future administrations will have more flexibility in debating whether the federal government should increase its scope or reduce taxes. Copyright 2002 by The Policy Studies Organization.

Media System, Public Knowledge and Democracy: A Comparative Study

This article addresses the implications of the movement towards entertainment-centred, market-driven media by comparing what is reported and what the public knows in four countries with different media systems. The different systems are public service (Denmark and Finland), a `dual' model (UK) and the market model (US). The comparison shows that public service television devotes more attention to public affairs and international news, and fosters greater knowledge in these areas, than the market model. Public service television also gives greater prominence to news, encourages higher levels of news consumption and contributes to a smaller within-nation knowledge gap between the advantaged and disadvantaged. But wider processes in society take precedence over the organization of the media in determining how much people know about public life