Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001–2018

Background: Treatment of patients with hemophilia has advanced over the past decades, but it is unknown whether this has resulted in a normal life expectancy in the Netherlands. Objective: This observational cohort study aimed to assess all-cause and cause-specific mortality in patients with hemophilia in the Netherlands between 2001 and 2018 and to compare mortality and life expectancy with previous survival assessments from 1973 onward. Patients/methods: All 1066 patients with hemophilia who participated in a nationwide survey in 2001 were followed until July 2018. Results: Information on 1031 individuals (97%) was available, of whom 142 (14%) deceased during follow-up. Compared with the general Dutch male population, mortality of patients with hemophilia was still increased (standardized mortality ratio: 1.4, 95% confidence interval: 1.2–1.7). Intracranial bleeding and malignancies were the most common causes of death. Estimated median life expectancy of patients with hemophilia was 77 years, 6 years lower than the median life expectancy of the general Dutch male population (83 years). Over the past 45 years, death rates of patients with hemophilia have consistently decreased, approaching the survival experience of the general population. Over the past decades, mortality due to human immunodeficiency virus and hepatitis C virus infections has decreased, death due to intracranial hemorrhages has increased, and death due to ischemic hear

Whitecaps and the marine atmosphere, report no. 3

This report covers the period from 1 July, 1980 to 31 March, 1981, and is devoted to a description of the work carried out, and the results obtained, during this interval on the on-going ONR-sponsored study of "The Influence of Whitecaps on the Marine Atmosphere". The publications to date resulting from the whitecap project are listed in Table 1.1., with those numbered from 10 onward relating specifically to the period covered by this report. The full text of the paper delivered on 28 July, 1980 in Manchester at the VI International Conference on Atmospheric Electricity (item 10) is included as Chapter 2 of this report (an abstract of this paper appeared in the July 1980 report to ONR, i.e. in item 9). The note submitted in January, 1981 to the JASIN News (item 12) is reproduced as Chapter 7 of the present report

Void fraction measurements in breaking waves

This paper describes detailed measurements and analysis of the time-varying distribution of void fractions in three different breaking waves under laboratory conditions. The measurements were made with highly sensitive optical fibre phase detection probes and document the rapid spatial and temporal evolutions of both the bubble plume generated beneath the free surface and the splashes above. Integral properties of the measured void fraction fields reveal a remarkable degree of similarity between characteristics of the two-phase flow in different breaker types as they evolve with time. Depending on the breaker type, the energy expended in entraining air and generating splash accounts for a minimum of between 6.5 and 14% of the total energy dissipated during wave breaking

Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001-2018

Background Treatment of patients with hemophilia has advanced over the past decades, but it is unknown whether this has resulted in a normal life expectancy in the Netherlands.Objective This observational cohort study aimed to assess all-cause and cause-specific mortality in patients with hemophilia in the Netherlands between 2001 and 2018 and to compare mortality and life expectancy with previous survival assessments from 1973 onward.Patients/methods All 1066 patients with hemophilia who participated in a nationwide survey in 2001 were followed until July 2018.Results Information on 1031 individuals (97%) was available, of whom 142 (14%) deceased during follow-up. Compared with the general Dutch male population, mortality of patients with hemophilia was still increased (standardized mortality ratio: 1.4, 95% confidence interval: 1.2-1.7). Intracranial bleeding and malignancies were the most common causes of death. Estimated median life expectancy of patients with hemophilia was 77 years, 6 years lower than the median life expectancy of the general Dutch male population (83 years). Over the past 45 years, death rates of patients with hemophilia have consistently decreased, approaching the survival experience of the general population. Over the past decades, mortality due to human immunodeficiency virus and hepatitis C virus infections has decreased, death due to intracranial hemorrhages has increased, and death due to ischemic heart disease has remained consistently low over time.Conclusions Survival in patients with hemophilia in the Netherlands has improved over time but is still lower than that of the general population.Thrombosis and Hemostasi