901 research outputs found
Properties of Random Graphs with Hidden Color
We investigate in some detail a recently suggested general class of ensembles
of sparse undirected random graphs based on a hidden stub-coloring, with or
without the restriction to nondegenerate graphs. The calculability of local and
global structural properties of graphs from the resulting ensembles is
demonstrated. Cluster size statistics are derived with generating function
techniques, yielding a well-defined percolation threshold. Explicit rules are
derived for the enumeration of small subgraphs. Duality and redundancy is
discussed, and subclasses corresponding to commonly studied models are
identified.Comment: 14 pages, LaTeX, no figure
Correlations in Scale-Free Networks: Tomography and Percolation
We discuss three related models of scale-free networks with the same degree
distribution but different correlation properties. Starting from the
Barabasi-Albert construction based on growth and preferential attachment we
discuss two other networks emerging when randomizing it with respect to links
or nodes. We point out that the Barabasi-Albert model displays dissortative
behavior with respect to the nodes' degrees, while the node-randomized network
shows assortative mixing. These kinds of correlations are visualized by
discussig the shell structure of the networks around their arbitrary node. In
spite of different correlation behavior, all three constructions exhibit
similar percolation properties.Comment: 6 pages, 2 figures; added reference
Universality in percolation of arbitrary Uncorrelated Nested Subgraphs
The study of percolation in so-called {\em nested subgraphs} implies a
generalization of the concept of percolation since the results are not linked
to specific graph process. Here the behavior of such graphs at criticallity is
studied for the case where the nesting operation is performed in an
uncorrelated way. Specifically, I provide an analyitic derivation for the
percolation inequality showing that the cluster size distribution under a
generalized process of uncorrelated nesting at criticality follows a power law
with universal exponent . The relevance of the result comes from
the wide variety of processes responsible for the emergence of the giant
component that fall within the category of nesting operations, whose outcome is
a family of nested subgraphs.Comment: 5 pages, no figures. Mistakes found in early manuscript have been
remove
CO oxidation activity of Pt/CeO2 catalysts below 0ºC: Platinum loading effects
Reducing the operating temperature of oxidation catalysts is important for designing energy efficient processes, extending catalyst lifetime, and abating pollutants, especially in cold climates. Herein, high CO oxidation activity at sub-ambient temperatures is reported for Pt/CeO2 catalysts with high content of Pt in the form of dispersed Pt2+ and Pt4+ centers. Whereas the reference 1 wt%Pt catalyst was active for CO oxidation only above 100ᵒC, the 8 and 20 wt%Pt catalysts converted 60 and 90 % of CO, respectively, below 0ᵒC. Ionic platinum was shown to facilitate oxygen release from ceria and lower the light-off temperature of the reaction occurring through the Mars-van-Krevelen mechanism. However, the remarkable activity observed at sub-ambient temperatures for the ≥8 wt%Pt catalysts is proposed to involve O2 and CO reactants weakly adsorbed on PtOx clusters. The synergies between ionic platinum and nanostructured ceria reported in this work advance the knowledge-driven design of catalysts for low-temperature oxidation reactions
The spread of epidemic disease on networks
The study of social networks, and in particular the spread of disease on
networks, has attracted considerable recent attention in the physics community.
In this paper, we show that a large class of standard epidemiological models,
the so-called susceptible/infective/removed (SIR) models can be solved exactly
on a wide variety of networks. In addition to the standard but unrealistic case
of fixed infectiveness time and fixed and uncorrelated probability of
transmission between all pairs of individuals, we solve cases in which times
and probabilities are non-uniform and correlated. We also consider one simple
case of an epidemic in a structured population, that of a sexually transmitted
disease in a population divided into men and women. We confirm the correctness
of our exact solutions with numerical simulations of SIR epidemics on networks.Comment: 12 pages, 3 figure
First-line palliative HER2-targeted therapy in HER2-positive metastatic breast cancer is less effective after previous adjuvant trastuzumab-based therapy
Background. Survival of patients with human epidermal growth receptor 2 (HER2)-positive metastatic breast cancer (MBC) has improved dramatically since trastuzumab has become available, although the disease eventually progresses in most patients. This study investigates the outcome (overall survival [OS] and time to next treatment [TNT]) in MBC patients pretreated with trastuzumab in the adjuvant setting (TP-group) compared with trastuzumab-näive patients (TN-group) in order to investigate the possibility of trastuzumab resistance. Patients and Methods. Patients treated with first-line HER2-targeted- containing chemotherapy were eligible for the study. A power analysis was performed to estimate the minimum size of the TP-group. OS and TNT were estimated using Kaplan-Meier curves andmultivariable Cox proportional hazards models. Results. Between January 1, 2000, and June 1, 2014, 469 patients were included, of whom 82 were in the TP-group and 387 were in the TN-group. Median OS and TNT were significantly worse in the TP-group compared with the TN-group (17 vs. 30 months, adjusted hazard ratio [HR] 1.84 [1.15-2.96], p5.01 and 7 vs. 13 months, adjusted HR 1.65 [1.06-2.58], p5.03) after adjustment for age, year of diagnosis, diseasefree interval, hormone receptor status, metastatic site, and cytotoxic regimens. Conclusion. First-line trastuzumab-containing treatment regimens are less effective in patients with failure of adjuvant trastuzumab compared with trastuzumab-näive patients and might be due to trastuzumab resistance. The impact of trastuzumab resistance on the response on dual HER2 blockade with trastuzumab and pertuzumab and how resistance mechanisms can be used in the optimization of HER2-targeted treatment lines need further investigation.</p
Generating correlated networks from uncorrelated ones
In this paper we consider a transformation which converts uncorrelated
networks to correlated ones(here by correlation we mean that coordination
numbers of two neighbors are not independent). We show that this
transformation, which converts edges to nodes and connects them according to a
deterministic rule, nearly preserves the degree distribution of the network and
significantly increases the clustering coefficient. This transformation also
enables us to relate percolation properties of the two networks.Comment: 14 pages, 6 figures, Revtex
Spectra of complex networks
We propose a general approach to the description of spectra of complex
networks. For the spectra of networks with uncorrelated vertices (and a local
tree-like structure), exact equations are derived. These equations are
generalized to the case of networks with correlations between neighboring
vertices. The tail of the density of eigenvalues at large
is related to the behavior of the vertex degree distribution
at large . In particular, as , . We propose a simple approximation, which enables us to
calculate spectra of various graphs analytically. We analyse spectra of various
complex networks and discuss the role of vertices of low degree. We show that
spectra of locally tree-like random graphs may serve as a starting point in the
analysis of spectral properties of real-world networks, e.g., of the Internet.Comment: 10 pages, 4 figure
Magnetic fields in cosmic particle acceleration sources
We review here some magnetic phenomena in astrophysical particle accelerators
associated with collisionless shocks in supernova remnants, radio galaxies and
clusters of galaxies. A specific feature is that the accelerated particles can
play an important role in magnetic field evolution in the objects. We discuss a
number of CR-driven, magnetic field amplification processes that are likely to
operate when diffusive shock acceleration (DSA) becomes efficient and
nonlinear. The turbulent magnetic fields produced by these processes determine
the maximum energies of accelerated particles and result in specific features
in the observed photon radiation of the sources. Equally important, magnetic
field amplification by the CR currents and pressure anisotropies may affect the
shocked gas temperatures and compression, both in the shock precursor and in
the downstream flow, if the shock is an efficient CR accelerator. Strong
fluctuations of the magnetic field on scales above the radiation formation
length in the shock vicinity result in intermittent structures observable in
synchrotron emission images. Resonant and non-resonant CR streaming
instabilities in the shock precursor can generate mesoscale magnetic fields
with scale-sizes comparable to supernova remnants and even superbubbles. This
opens the possibility that magnetic fields in the earliest galaxies were
produced by the first generation Population III supernova remnants and by
clustered supernovae in star forming regions.Comment: 30 pages, Space Science Review
Mesoscopics and fluctuations in networks
We describe fluctuations in finite-size networks with a complex distribution
of connections, . We show that the spectrum of fluctuations of the number
of vertices with a given degree is Poissonian. These mesoscopic fluctuations
are strong in the large-degree region, where ( is the
total number of vertices in a network), and are important in networks with
fat-tailed degree distributions.Comment: 3 pages, 1 figur
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