Group analysis of a class of nonlinear Kolmogorov equations

A class of (1+2)-dimensional diffusion-convection equations (nonlinear Kolmogorov equations) with time-dependent coefficients is studied with Lie symmetry point of view. The complete group classification is achieved using a gauging of arbitrary elements (i.e. via reducing the number of variable coefficients) with the application of equivalence transformations. Two possible gaugings are discussed in detail in order to show how equivalence groups serve in making the optimal choice.Comment: 12 pages, 4 table

The essence and rule of Russian manufacture

Статья посвящена поиску ответов на вопросы, касающиеся развития предпринимательства в России.The article is devoted to the search for answers to questions concerning the development of entrepreneurship in Russia

PROGNOSTIC VALUE OF pSTAT3 EXPRESSION IN DIFFUSIVE B-LARGE CELL LYMPHOMA IN THE RUSSIAN PATIENT SAMPLE

The aim of the study was to evaluate the prognostic value of pSTAT3 expression in diffuse B-large cell lymphoma (DLBCL) in a Russian sample of patients. Material and methods. Retrospectively, the results of an examination of 50 patients with newly diagnosed DLBCL in the period from 2014 to 2017 were evaluated. Using immunohistochemical and morphometric methods, the relative number of tumor cells expressing pSTAT3 was determined. The relationship of various levels of marker expression with clinical and laboratory parameters was analyzed, and long-term results of patient therapy were evaluated. Results and discussion. The overexpression of pSTAT3 protein is associated with a non-GCB subtype of the disease, an advanced stage, the patients of 60 years and older age, as well as with a lower frequency of achieving complete remissions with DLBCL. Patients with a high degree of marker expression in tumor cells had lower rates of overall (OS) and progressive survival (PFS). It was revealed that the marker under study has good predictive ability, but is not an independent prognosis factor for DLBCL. Conclusions. The level of expression of pSTAT3 is an informative factor that allows predicting the response to standard therapy for diffuse B-large cell lymphoma. The indicated marker may be useful for identifying patients who need individualization of therapeutic tactics for this disease

Значение экспрессии рАКТ1 при диффузной В-крупноклеточной лимфоме

Aim. To evaluate the prognostic value of pAKT1 expression by tumor cells in patients with diffuse large B-cell lymphoma.Materials and methods. The study included 90 patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), who were treated at the clinic of Kirov Research Institute of Hematology and Blood Transfusion from 2014 to 2017 and received standard first-line polychemotherapy according to the R-CHOP regimen. Using immunohistochemical and morphometric methods, the relative number of tumor cells expressing pAKT1 was determined. Using the two-sided Fisher’s exact test, the relationship of different levels of marker expression with clinical and laboratory parameters of patients and long-term treatment results was analyzed. The impact of pAKT1 on the risk of an adverse event was assessed using the Cox regression analysis.Results. Overexpression of pAKT1 is associated with unfavorable clinical characteristics of patients with DLBCL, excessive expression of the BCL2 and c-Myc oncoproteins, as well as with low rates of overall and progressive survival. Overexpression of pAKT1 is an independent prognostic factor and statistically significantly affects the risk of an adverse outcome in DLBCL.Conclusion. The degree of pAKT1 expression is an informative criterion that allows to predict the course of diffuse large B-cell lymphoma. It is advisable to use the indicated marker when stratifying patients into risk groups.Цель – оценить прогностическое значение экспрессии рАКТ1 опухолевыми клетками у больных диффузной В-крупноклеточной лимфомой.Материалы и методы. В исследование включены 90 пациентов с впервые диагностированной диффузной В-крупноклеточной лимфомой (ДВККЛ), наблюдавшиеся в клинике института с 2014 по 2017 г. и получавшие стандартную полихимиотерапию первой линии по схеме R-CHOP. С помощью иммуногистохимического и морфометрического методов определено относительное количество экспрессирующих рАКТ1 опухолевых клеток. С помощью точного двухстороннего критерия Фишера проанализирована взаимосвязь различных уровней экспрессии маркера с клинико-лабораторными показателями пациентов и отдаленными результатами лечения. Оценку влияния рАКТ1 на риск наступления неблагоприятного события проводили с помощью регрессионного анализа Кокса.Результаты. Гиперэкспрессия рАКТ1 ассоциирована с неблагоприятными клиническими характеристиками больных диффузной В-крупноклеточной лимфомой, избыточной экспрессией онкобелков BCL2, cMyc, а также низкими показателями общей и беспрогрессивной выживаемости. Гиперэкспрессия рАКТ1 является независимым фактором прогноза и статистически значимо влияет на риск возникновения неблагоприятного исхода при ДВККЛ.Заключение. Степень экспрессии рАКТ1 является информативным критерием, позволяющим прогнозировать течение диффузной В-крупноклеточной лимфомы. Указанный маркер целесообразно использовать при стратификации пациентов на группы риска

Different procedures for evaluation of left ventricular hypertrophy in overweight hypertensive adolescents

Studies of arterial hypertension in adults could identify factors aggravating its course and increasing the risk of poor outcomes as myocardial infarction, stroke, etc. Myocardial hypertrophy is a major marker for disease severity in children. It may be underestimated in certain situations, in obesity in particular. This investigation analyzed the impact of the most common myocardial mass (MM) indices on the detection rate of myocardial hypertrophy in hypertensive adolescents: 1) ММ/Height2,7 (>45 g/m2,7); 2) ММ/Height2,7(>48 g/ m2,7), 3) MM/Height2,7 (>51 g/m2,7); 4) zMM(F) (>1,65); 5) ММ/BSA(>115 g/m2); 6) MM/Body weight (>3,0 g/kg). The findings depended on the used index and varied from 11,3 to 35,9%. The myocardial mass correlated with systolic blood pressure and exercise time. Hypertrophy was frequently encountered in persistent hypertension (28,6%; p<0,05) and obesity (p<0,05). ММ/Height2,7(>48 g/m2,7) and zMM(F) (>1,65) are the most adequate indices for the detection of myocardial hypertrophy in these patients