3-Phenyl Derivatives of Trans-2-(Aryl/Pyridinyl)Vinyl-3H-Quinazolin-4-ones: Synthesis and Fluorescent Properties

This work was supported by Russian Foundation for Basic Research (grant № 18-03-00112)

NOVEL 8-NITROSUBSTITUTED 1, 3-BENZOTHIAZIN-4-ONES

Many synthetic benzothiazines play an important role in the treatment of various diseases. Some 2-amino substituted 1, 3-benzothiazin-4-ones (2-amino-1, 3-benzothiazinones) represent a promising new class of antitubercular agents. Recently we have reported the synthesis of novel fluorinated 2-cycloalkylaminosubstituted 1, 3-benzothiazin-4-ones through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates and subsequent cyclization of fluorobenzoyl-thioureas, and 5-fluoro-2-(4-ethoxycarbonylpiperazin-1-yl)-1, 3-benzothiazin-4-one was chosen as leading compound.This work was supported by the Ministry of Science and Higher Education of Russian Federation (project № FEUZ-2020-0058 (Н687.42Б.223/20)) and the Russian Foundation for Basic Research (grant # 18-03-00112)

Cyano and CF3 Derivatives of 2-Aryl- and 2-Thienylquinazoline: Synthesis and Study of Optical Properties

This work was supported by the Russian Foundation for Basic Research (grant # 18-03-00112) and Russian Science Foundation (project # 19-73-10144)

Fluorinated 2-Carbonylpiperazino-1,3-Benzothazin-4-ones as Perspective Antitubercular Agents

This work was supported by Russian Foundation for Basic Research (grant № 15-13-00077)

Effects of α-amylase, endo-xylanase and exoprotease combination on dough properties and bread quality

Received: January 31st, 2021 ; Accepted: May 2nd, 2021 ; Published: May 6th, 2021 ; Correspondence: [email protected] enzymes composition is an actual alternative to chemicals to improve functional properties of flours and to generate changes in the structure of the dough and bread quality. The objective of this study was to analyze the individual and synergistic effects of enzymes preparation (α-amylase, endo-xylanase and exoprotease), newly produced in Russia, on dough properties and bread quality made from wheat flour with different amylolytic activity. Reofermentometric results revealed decreases in gas-forming capacity of dough by 10.0–13.9% when single α-amylase preparates were used. The α-amylase addition had significant effect on gas retention coefficient in flour possessed low amylolytic activity. The effect of endo-xylanase and exoprotease on hydration and amount of wheat gluten was established. The fractional composition of gluten proteins in the dough made with combination of endo-xylanase and exoprotease was established using Lowry method immediately after kneading and after fermentation. It was found that mainly water-soluble, alcohol-soluble and alkaline-soluble proteins were undergone by transformation. The bread with enzymes had a higher specific volume, porosity and aldehyde content and lower shape stability indicator than the control bread made without enzymes. Bread with enzymes was characterized by tenderer and not crumbly crumb with developed thin-walled uniform porosity compared to the control. The crusts were more brightly colored. The combined usage of α-amylase and endo-xylanase and exoprotease retarded bread staling during 5-day storage period. New enzyme composition may be a potentially strong candidate for future applications in the bread-making industry

(E)-2-(hydroxystyryl)-3-phenylquinazolin-4(3H)-ones: Synthesis, photochemical and luminescent properties

The new (E)-2-(hydroxyarilethenyl)-3-phenylquinazolin-4(3H)-ones with various substituents in phenyl fragment were synthesized. The effect of electron donor and acceptor substituents (±M) in quinazolinones on luminescence intensity and dual emission in 550-650-nm wavelength range was shown. The fact of the reversible photo/thermal E-Z isomerization for several substances was established. The (E)-2-(5-chloro-2-hydroxystyryl)-3-phenylquinazolin-4(3H)-one had shown the best combination of photochemical (E-Z isomerization) and photophysical properties. The (E)-2-(2-hydroxy-5-morpholinostyryl)-3-phenylquinazolin-4(3H)-one had revealed the best ESIPT-luminescence (Φrel = 5.3 %). © Arkat. All Rights Reserved.Russian Foundation for Basic Research, RFBR: 18-03-00112This work was supported by the Russian Foundation for Basic Research (grant 18-03-00112). Analytical studies were carried out using equipment of the Center for Joint Use SSpectroscopy and ?nalysis of Organic Compounds ? at the Postosvky Institute of Organic Synthesis of the Russian Academy of Sciences (Ural Branch)

Antiviral Agents – Benzazine Derivatives

[Figure not available: see fulltext.] The review outlines the results of studies of the antiviral activity of quinoline, quinoxaline, and quinazoline derivatives published over the past 5 years. The supplied data indicate the enormous potential of benzazines for the design of effective antiviral drugs. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.This work was supported by the Ministry of Science and Higher Education of the Russian Federation (project No. FEUZ-2020-0058 (N687.42B.223/20))

THE DESIGN AND SYNTHESIS OF NOVEL 3,5-DIARYL[1,2,4]TRIAZOLO[4,3-C]QUINAZOLINE BASED FLUOROPHORES

This work was supported by the Russian Scientific Foundation (project 22-23-00006)

V-SHAPED FLUOROPHORES - 2,3-BIS(ARYLTHIENYL)QUINOXALINE DERIVATIVES: SYNTHESIS AND PHOTOPHYSICAL PROPERTIES

This work was supported by the Russian Scientific Foundation (project 21-13-00304)

NOVEL FLUORINE-CONTAINING DERIVATIVES OF 2-METHYLTHIO-4-ARYLAMINOQUINAZOLINES

Quinazoline represents an attractive scaffold for drug design, and some 4-aminosubstituted quinazolines are of great value as potential antitubercular agents.This work was supported by the Ministry of Science and Higher Education of Russian Federation (project № FEUZ-2020-0058 (Н687.42Б.223/20)) and the Russian Foundation for Basic Research (grant # 18-03-00112)