Towards effective indirect radioisotope energy converters with bright and radiation hard scintillators of (Gd,Y)3Al2Ga3O12 family

Ceramics of quaternary garnets (Gd,Y)3Al2Ga3O12 doped with Ce, Tb have been fabricated and evaluated as prospective materials for indirect energy converters of α-and β-voltaic. Samples were characterized at excitation with an X-ray source and an intense 150 keV electron beam and showed good temperature stability of their emission and tolerance to irradiation. The role of X-rays accompanied the α-particle emitting in the increase of the conversion efficiency is clarified. The garnet-type structure of the matrix in the developed materials allows the production of quality crystalline mass with a light yield exceeding that of the commonly used YAG: Ce scintillator by a factor of two times. © 2022 Korean Nuclear SocietyMinistry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2021-1353, FEUZ-2020-0060; Ministerstwo Edukacji i Nauki, MNiSW: 075-11-2021-070; Ministry of Science and Higher Education of the Russian FederationAuthors with affiliations b, d, e and f acknowledge support from Russian Ministry of Science and Education grant No. 075-15-2021-1353 . The scientific equipment provided by shared research facilities “Scientific Research Analytical Center of National Research Center “Kurchatov Institute” – IREA” was used, with financial support of Russian Federation, represented by the Ministry of Science and Higher Education, agreement No. 075-11-2021-070 dated August 19, 2021. The work was partially supported by the Ministry of Science and Higher Education of the Russian Federation (through the basic part of the government mandate, project No. FEUZ-2020-0060 ) (authors with affiliation “c”).Authors with affiliations b, d, e and f acknowledge support from Russian Ministry of Science and Education grant No. 075-15-2021-1353. The scientific equipment provided by shared research facilities “Scientific Research Analytical Center of National Research Center “Kurchatov Institute” – IREA” was used, with financial support of Russian Federation, represented by the Ministry of Science and Higher Education, agreement No. 075-11-2021-070 dated August 19, 2021. The work was partially supported by the Ministry of Science and Higher Education of the Russian Federation (through the basic part of the government mandate, project No. FEUZ-2020-0060) (authors with affiliation “c”)

Metabolic syndrome in patients with chronic kidney disease

At the present time has been steadily increasing prevalence of chronic kidney disease (CKD). CKD is a direct risk factor for mortality from cardiovascular disease. Renal pathology leads to the tendency of high blood pressure, disorders of carbohydrate and lipid metabolism, the development of oxidative stress, chronic inflammation and several other haemodynamic and metabolic changes. Most of them are components of metabolic syndrome (MS). MS has an extremely unfavourable prognostic significance for cardiovascular disease. In the article presents materials from both Russian and foreign literature, describing the mechanisms of development some disorders in MS and CKD. It also describes interconnections between causes and effects. MS and CKD are closely linked. The formation of MC in the background of CKD burdens its course and lead to increased cardiovascular risk.В настоящее время неуклонно растет распространенность хронической болезни почек (ХБП). Рядом исследований показано, что ХБП является непосредственным фактором риска смертности от сердечно-сосудистых заболеваний. Патология почек приводит к тенденции повышения артериального давления, способствует нарушению углеводного и липидного обмена, развитию оксидативного стресса, хронического воспаления и ряду других гемодинамических и метаболических изменений. Большая часть из них являются компонентами метаболического синдрома (МС). МС имеет крайне неблагоприятное прогностическое значение в отношении сердечно-сосудистой патологии. В работе представлены материалы отечественной и зарубежной литературы, описывающие механизмы развития отдельных нарушений при МС и ХБП и их причинно-следственные связи. МС и ХБП тесно связаны между собой. Показано, что формирование МС на фоне ХБП отягощает её течение и приводит к нарастанию сердечно-сосудистого риска

Quantification of C1 esterase inhibitor in human serum by enzyme-linked immunosorbent assay: Correlation with turbidimetric immunoassay

C1 inhibitor of serine proteases (C1-INH) performs a regulatory function in the complement system and vascular permeability. Deficiency of C1-INH leads to various forms of angioedema, including hereditary angioedema (HAE). The cause of HAE is a genetically determined violation of the synthesis of C1-INH. A decrease in the level of C1-INH to 50% relative to the norm leads to an increase in the production of bradykinin, which is the basis for the diagnosis of HAE. The development of affordable ELISA for the quantitative determination of C1-INH is a popular direction for clinicians. During the development of a new kit for quantitative determination of C1-INH, two mouse monoclonal antibodies (mAb) with different epitope specificities were obtained. On their basis, a sandwich-type ELISA was developed. The specificity of the obtained mAb's was confirmed using the medical device “Berinert”. To prepare calibrators, C1-INH was affinity purified from human blood plasma using a sorbent with immobilized mAbs. The identity of the C1-INH protein was confirmed by PAGE electrophoresis, immunoblotting, and mass spectrometry on MALDI-TOF/TOF UltrafleXtreme mass spectrometer. To assess the quality indicators of developed reagents kit, studies were carried out in accordance with GOST R 51352-2013 and TU 21.20.23-041-01967164-2022. Values of quality indicators: accuracy — 93.53%; measurement linearity interval — 22.00-176.07 ng/mL. Using the developed ELISA test system, we examined 28 blood sera from healthy donors and 7 blood sera from patients with confirmed HAE. In the same samples, the content of C1-INH was determined by turbidimetric method, using the "Diagnostic reagents for in vitro immunochemical studies of specific blood proteins. Model: C1-esterase inhibitor (C1 EsteraseInhibitor)" (Aptec, Belgium). The correlation coefficient was 0.94 (p < 0.05). It was found that the diagnostic sensitivity and specificity of the developed ELISA is 100%. As a result of the study, an original ELISA test system for the quantitative determination of C1-INH was developed "Reagent kit for enzyme-linked immunosorbent assay of human C1-inhibitor (C1-inh PS)"

Визначення оптимального варіанта енергоефективного малоповерхового будівлі.

В статье изложены результаты выбора оптимального варианта проекта малоэтажного жилого дома.У статті викладені результати вибору оптимального варіанту проекту малоповерхового житлового будинку

Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09

An isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza. The comparison group consisted of patients infected with influenza A(H1N1)pdm09 virus. In vaccinated volunteers the more active response of influenza-specific antibodies both with neutralizing properties (IgG1, IgG2, IgG3) and associated with allergic inflammation (IgG and IgE) was observed in comparison with infected patients. The high activity of the virus-specific serum IgA was observed both in infected patients and vaccinated volunteers. Antiviral hemagglutinating activity of antibodies in post-vaccination sera of vaccinated volunteers, unlike sera obtained from infected patients in the phase of recovery, were higher than protective level (1:40) according to HAI data

THE USE OF HYALURONIC ACID IN GONARTHROSIS IN REAL CLINICAL PRACTICE

Objectives. To assess the frequency and preferences when assigning intraarticular therapy with hyaluronic acid (HA) in knee оsteoarthritis (ОА) in clinical practice. Material and methods. The analysis of 200 patient records with knee OA treated at the regional center of rheumatology to assess the frequency and spectrum assignment of НА, profile of patients, who were prescribed HA, and its effectiveness. To assess the opinions of rheumatologists on intraarticular therapy with НА we conducted an anonymous questionnaire of 20 rheumatologists of Ekaterinburg. Results. The analysis showed that intraarticular НА therapy was recommended by rheumatologists to 46% of patients with knee ОА, of which the treatment was performed in only 35%. Patients who received treatment were older and more often took NSAIDs and symptomatic slow-acting drugs. Intra-articular НА therapy was effective in 69% of patients. НА with higher molecular weight were more effective, although rheumatologists prefer НА with low molecular weight. Conclusion. In clinical practice, НА is used widely in the treatment of knee ОА, a positive effect from the treatment noted in more than a half of patients

QUALITY OF WOOD LITTER AS AN INFORMATIVE INDICATOR OF FUNCTIONAL CLASSIFICATION OF FORESTS

Relevance and goals. In the context of global climate change, the climate-regulating function of forests deserves special attention. There is still no functional classification of forests according to the effectiveness of their carbon storage function. The purpose of this article is to discuss an approach to such classification based on the assessment of the quality of tree litter. Objects and methods. To test the approach to the identification of functional types of forests (FTL) based on the quality of tree litter, taking into account the position in the landscape and the mechanical composition of soil-forming rocks, data on soils and vegetation obtained at 23 sites operating in the subzone of coniferous-broadleaf forests of the European part of Russia on the territory of Bryansk Polesie and Moskvoretsko-Okskaya plain were used. For indirect (on the ecological scale of E. Landolt using the SpeDiv program) to assess differences in the soil richness of forests belonging to different FTLS, the species composition of 160 descriptions of forest vegetation of the Moscow, Bryansk, Smolensk, Kostroma regions, Krasnodar Krai and the Republic of Adygea (North-Western Caucasus) was analyzed. Results. Examples of functional forest types (FTL) for coniferous and broad-leaved forests of the European part of Russia are given. The differences in the level of soil carbon accumulation between different FTLS are shown, and a preliminary assessment of the influence of the position in the landscape and the mechanical composition of soils on the accumulation of carbon in soils within FTLS is given. Conclusion. Based on the quality of the fall of tree litter, 15 FTL were identified, which are confirmed by examples based on geobotanical descriptions of forest communities common in the zone of coniferous-deciduous forests of the European part of Russia and in the belt of coniferous-deciduous forests of the North-Western Caucasus. The validity of the allocation of FTL for the efficiency of carbon accumulation in soils based on the quality of plant litter, taking into account the influence of “external factors” (the position in the landscape and the mechanical composition of soil-forming rocks) is confirmed by data obtained at 23 sites; estimates of the carbon reserves in the soil, as well as the soil richness estimated on an ecological scale, revealed differences between the allocated FTLS. Differences in carbon stocks in forest ecosystems in the same FTL formed on loamy and sandy loam soil-forming rocks were revealed. Differences in soil carbon reserves in forests belonging to the same FTL, but formed at different positions in the landscape, have been confirmed; in transit landscapes, soil carbon reserves are higher than in autonomous ones

The results of the use of placental preparations in cosmetology

The article discusses changes in histological and immunohistochemical parameters of the skin with the use of placental preparations. A comparative characteristic of changes in the number of pro-inflammatory and anti-inflammatory interleukins, growth factors, and basic structural proteins of the skin in patients treated with various procedures that play a role in improving skin quality, in monotherapy and in combinationВ статье рассмотрены изменения гистологических и иммуногистохимических показателей кожи при применении плацентарных препаратов. Проведена сравнительная характеристика изменений количества провоспалительных и противовоспалительных интерлейкинов, факторов роста, основных структурных белков кожи у пациентов, получавших различные процедуры, играющие роль в улучшении качества кожи, в монотерапии и при их комбинаци