93 research outputs found
Изучение фармакокинетики [3Н]-циклопролилглицина в крови крыс
Resume. The objective of this study is to evaluate pharmacokinetic parameters of tritium-labeled cycloprolylglycine [3H] -CPG following intravenous bolus administration of 5.7 μg (2 mCi). [3H] -CPG was prepared by solid-state catalytic isotopic exchange with spillover-tritium. It was found that plasma concentration-time profile of [3H] -CPG is adequately fit by a two-compartment model. The pharmacokinetic parameter estimates revealed rapid а-phase (distribution phase) (T1/2α min) followed by a slower β-phase of elimination (T1/2β 80 min). These findings are consistent with previous results of pharmacokinetic study of CPG as a noopept metabolite. CPG is differ significantly from other therapeutic peptides in pharmacokinetic profile (T1/2 , MRT, etc), which implies that CPG has a more prolonged duration of action.Изучена фармакокинетика меченого по тритию метаболита ноопепта циклопролилглицина [3Н]-ЦПГ после внутривенного болюсного введения в дозе 5,7 мкг (2 мКи). Мечение субстанции ЦПГ проводили с помощью реакции высокотемпературного твердофазного каталитического изотопного обмена. Обнаружено, что временной характер изменений концентрации [3Н]-ЦПГ в крови крыс подчиняется двухкамерной модели. Расчёт фармакокинетических параметров показал, что α-фаза (фаза распределения) протекает очень быстро, а β-фаза элиминации [3Н]-ЦПГ достаточно продолжительна. При этом величина Т1/2α составляет 1 мин, а Т1/2β - 80 мин. Эти данные согласуются с ранее полученными результатами по фармакокинетике ЦПГ как метаболита, образующегося из лекарственного препарата ноопепт. ЦПГ существенно отличается от других дипептидных соединений по величинам фармакокинетических параметров (Т1/2e , MRT и др.), что предполагает наличие у него большей продолжительности фармакологического действия
Environmental impact of transport and technological activities in Krasnoyarsk, prospect of using gas-motor fuel
Study on the efficiency of ARPD (asphaltenes, resin and paraffin deposit) hydrocarbon solvents
Identification of qualitative regularities in the functioning of neural network models of a critical resource of lubricating oils
Research of engine and transmission oils for thermo-oxidative stability with cyclic temperature changes
Photometric Monitoring of Thermal Stability of Motor Oils and Effect of Thermal Degradation Products on Antiwear Properties
Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.The results of determination of thermal stability of mineral and partly synthetic motor oils are
presented. The criterion of thermal stability is substantiated and the correlation between it and
antiwear properties of the oils is determined. Direct photometric measurement method, which helps
obtain an integral parameter of accumulation of all degradation products in the studied oil that can
be determined from the luminous flux absorption coefficient, is chosen as the basic method of
evaluation of thermal degradation processes. The essential feature of the method consists in
comprehensive evaluation of thermal stability and antiwear properties of lube oils from the parameters,
namely, the coefficient of luminous flux absorption, relative viscosity, vaporizability, and wear.
Correlations of optical properties, viscosity, vaporizability, and antiwear properties of the lube oils
with thermostating temperature are obtained, and based on them the limiting temperature of lube oil
performing ability was established
METHOD OF MONITORING THERMAL STABILITY OF MOTOR OILS AND INFLUENCE OF THERMAL DEGRADATION PRODUCTS ON WEAR RESISTANCE PROPERTIES
The results of determination of thermal stability of mineral and semisynthetic motor oils are presented. The thermal stability criterion is validated and the link between it and the wear resistance properties of motor oils is determine
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