Efficient organisation of the contralateral hemisphere connectome is associated with improvement in intelligence quotient after paediatric epilepsy surgery

ObjectiveAims of epilepsy surgery in childhood include optimising seizure control and facilitating cognitive development. Predicting which children will improve cognitively is challenging. We investigated the association of the pre-operative structural connectome of the contralateral non-operated hemisphere with improvement in intelligence quotient (IQ) post-operatively.MethodsConsecutive children who had undergone unilateral resective procedures for epilepsy at a single centre were retrospectively identified. We included those with pre-operative volume T1-weighted non-contrast brain magnetic resonance imaging (MRI), no visible contralateral MRI abnormalities, and both pre-operative and two years post-operative IQ assessment. The MRI of the hemisphere contralateral to the side of resection was anatomically parcellated into 34 cortical regions and the covariance of cortical thickness between regions was used to create binary and weighted group connectomes.ResultsEleven patients with a post-operative IQ increase of at least 10 points at two years were compared with twenty-four patients with no change in IQ score. Children who gained at least 10 IQ points post-operatively had a more efficiently structured contralateral hemisphere connectome with higher global efficiency (0.74) compared to those whose IQ did not change at two years (0.58, p=0.014). This was consistent across thresholds and both binary and weighted networks. There were no statistically significant group differences in age, sex, age at onset of epilepsy, pre-operative IQ, mean cortical thickness, side or site of procedure, two year post-operative Engel scores or use of anti-seizure medications between the two groups. ConclusionsSurgical procedures to reduce or stop seizures may allow children with an efficiently structured contralateral hemisphere to achieve their cognitive potential. <br/

Nanoparticle ZnS:Ag/ 6 LiF—a new high count rate neutron scintillator with pulse shape discrimination

A neutron sensitive scintillator employing nanoparticles of ZnS:Ag has been developed for the first time. Pulse shape differences between neutron and gamma signals were observed in this material and neutron-gamma discrimination was applied. With initial signal processing parameters, gamma sensitivities of 8.5×10−6 to 60Co gammas were achieved. The average primary decay of neutron scintillation in nanoparticle ZnS:Ag/6LiF was measured to be 18ns, and afterglow was significantly suppressed in comparison to standard ZnS:Ag/6LiF scintillators that employ micron sized ZnS:Ag. Fast decay times and minimal afterglow indicate potential for use in high count rate capability applications. Prospective count rate capabilities were investigated here as proof of concept, with rates of 1.12Mcps measured for a single readout channel with less than 3.5% count loss. This is approximately 70 times greater than the count rate capability of the current standard ZnS:Ag/6LiF scintillation detectors. With improvements to signal processing and scintillator composition, nanoparticle ZnS:Ag/6LiF could be a promising candidate for future high rate capability neutron detectors

YAP scintillators for resonant detection of epithermal neutrons at pulsed neutron sources

Recent studies indicate the resonance detector (RD) technique as an interesting approach for neutron spectroscopy in the electron volt energy region. This work summarizes the results of a series of experiments where RD consisting of YAlO3 (YAP) scintillators were used to detect scattered neutrons with energy in the range 1-200 eV. The response of YAP scintillators to radiative capture gamma emission from a U-238 analyzer foil was characterized in a series of experiments performed on the VESUVIO spectrometer at the ISIS pulsed neutron source. In these experiments a biparametric data acquisition allowed the simultaneous measurements of both neutron time-of-flight and gamma pulse height (energy) spectra. The analysis of the gamma pulse height and neutron time of flight spectra permitted to identify and distinguish the signal and background components. These measurements showed that a significant improvement in the signal-to-background ratio can be achieved by setting a lower level discrimination on the pulse height at about 600 keV equivalent photon energy. Present results strongly indicate YAP scintillators as the ideal candidate for neutron scattering studies with epithermal neutrons at both very low (<5degrees) and intermediate scattering angles. (C) 2004 American Institute of Physics

“Simultaneous and integrated neutron-based techniques for material analysis of a metallic ancient flute“

A metallic 19th century flute was studied by means of integrated and simultaneous neutron-based techniques: neutron diffraction, neutron radiative capture analysis and neutron radiography. This experiment follows benchmark measurements devoted to assessing the effectiveness of a multitask beamline concept for neutron-based investigation on materials. The aim of this study is to show the potential application of the approach using multiple and integrated neutron-based techniques for musical instruments. Such samples, in the broad scenario of cultural heritage, represent an exciting research field. They may represent an interesting link between different disciplines such as nuclear physics, metallurgy and acoustics

Diamond detector for high rate monitors of fast neutrons beams

A fast neutron detection system suitable for high rate measurements is presented. The detector is based on a commercial high purity single crystal diamond (SDD) coupled to a fast digital data acquisition system. The detector was tested at the ISIS pulsed spallation neutron source. The SDD event signal was digitized at 1 GHz to reconstruct the deposited energy (pulse amplitude) and neutron arrival time; the event time of flight (ToF) was obtained relative to the recorded proton beam signal t0. Fast acquisition is needed since the peak count rate is very high (~800 kHz) due to the pulsed structure of the neutron beam. Measurements at ISIS indicate that three characteristics regions exist in the biparametric spectrum: i) background gamma events of low pulse amplitudes; ii) low pulse amplitude neutron events in the energy range Edep = 1.5-7 MeV ascribed to neutron elastic scattering on 12C; iii) large pulse amplitude neutron events with En < 7 MeV ascribed to 12C(n,α)9Be and 12C(n,n')3α

Проблематика переходу до інформаційного суспільства

Аналізуються фундаментальні передумови, що є первинними в процесі творення інформаційного суспільства. Обґрунтовується теза, що електронна готовність та електронне залучення є основоположними факторами переходу суспільства від індустріального до інформаційного устрою. Подано основні характеристики цих понять та наголошено на їх значенні

Short induction gap gas electron multiplier (GEM) for X-ray spectroscopy

Experimental work was carried out to evaluate the performance of a Gas Electron Multiplier (GEM) operated with a micromesh readout plane that enabled the induction gap to be set at 50 [mu]m. We measured the essential operational parameters of this system using Ar(75%)-isobutane (25%) as the counter gas mixture. The measurements included the effective gain, effective gain stability, and the X-ray energy resolution using a 5.89 keV X-ray source. These studies demonstrated several advantages of the current system when compared with the standard operation, such as lower operational voltages, higher effective gains and improved effective gain stability.http://www.sciencedirect.com/science/article/B6TJM-4MCW7M1-F/1/f0700659b4d61e87ecd815040c63b24

Application of the microhole and strip plate detector for neutron detection

We introduce the microhole and strip plate (MHSP) detector as a micropattern detector for the detection of thermal and epithermal neutrons. Detection sensitivity is obtained by filling these detectors with 3He at high pressures. We propose the use of argon-xenon penning mixtures as the stopping gas as opposed to the usual carbon based stopping gases. These argon-xenon mixtures provide suitable gas gains for the high pressure/high resolution neutron detector applications. With these mixtures it is possible to obtain a sealed detector with only rare-gas filling which is simple to purify and not subject to ageing. An MHSP gas detector filled with a 3-bar argon/50-mbar xenon/6-bar helium mixture can achieve gains above 2×103. This mixture allows neutron detection efficiencies of about 70% at 1 Å for a 2.5-cm thick absorption region and intrinsic position resolution (full-width at half-maximum) of about 1.8 mm. The sensitivity to γ-rays of the present mixture will be the same when compared to that of 2.6-bar CF

Short induction gap gas electron multiplier (GEM) for X-ray spectroscopy

Experimental work was carried out to evaluate the performance of a Gas Electron Multiplier (GEM) operated with a micromesh readout plane that enabled the induction gap to be set at 50 [mu]m. We measured the essential operational parameters of this system using Ar(75%)-isobutane (25%) as the counter gas mixture. The measurements included the effective gain, effective gain stability, and the X-ray energy resolution using a 5.89 keV X-ray source. These studies demonstrated several advantages of the current system when compared with the standard operation, such as lower operational voltages, higher effective gains and improved effective gain stability.http://www.sciencedirect.com/science/article/B6TJM-4MCW7M1-F/1/f0700659b4d61e87ecd815040c63b24

Application of the microhole and strip plate detector for neutron detection

We introduce the microhole and strip plate (MHSP) detector as a micropattern detector for the detection of thermal and epithermal neutrons. Detection sensitivity is obtained by filling these detectors with 3He at high pressures. We propose the use of argon-xenon penning mixtures as the stopping gas as opposed to the usual carbon based stopping gases. These argon-xenon mixtures provide suitable gas gains for the high pressure/high resolution neutron detector applications. With these mixtures it is possible to obtain a sealed detector with only rare-gas filling which is simple to purify and not subject to ageing. An MHSP gas detector filled with a 3-bar argon/50-mbar xenon/6-bar helium mixture can achieve gains above 2×103. This mixture allows neutron detection efficiencies of about 70% at 1 Å for a 2.5-cm thick absorption region and intrinsic position resolution (full-width at half-maximum) of about 1.8 mm. The sensitivity to γ-rays of the present mixture will be the same when compared to that of 2.6-bar CF