CALCULATION OF BUILDINGS WITH COMPLEX GEOMETRIC SHAPES FOR WITHSTANDING WIND IMPACT

Objectives. The possibility of modeling wind flow during the design of buildings with complex geometric shapes in order to determine comfort parameters and zones is considered.Methods. The investigation of the impact of wind on a cylindrical building was carried out using Ansys 15.0 software.Results. A finite element model of a modern art museum building having a complex geometric shape is developed for the calculation of the wind flow and the definition of comfort zones. The computational region is chosen such that its borders do not affect the calculation results. The maximum wind speed is assumed to be 44 m/s at an altitude of 10 m from the ground level, this being the maximum in the region of Novorossiysk. The topography of the earth's surface around the model was considered flat. The surface of the building was assumed to be smooth while the surface of the surrounding terrain was assumed to be rough with a roughness parameter of 0,1 m. The parameters of the building orientation relative to the wind rise were varied during the numerical modeling. Three variants of computational models with varying building location and its geometric characteristics are developed. In the first variant, the building model is stretched along the X-axis; in the second variant, the acute angle of the building model's contour is oriented along the Y-axis; in the third variant, the building model is located and oriented along the Y-axis with its obtuse angle of the external contour of the building. The calculation results of a cylindrical building for wind impact correspond to SP 20.13330.2011. The comfort parameters and zones of a building having complex geometric shape are defined by means of numerical modeling of the wind flow. The discrepancy between the object's normative characteristics and the research results is revealed during the calculation of the wind load.Conclusion. The recommendations are given for choosing the optimal location of the museum building, taking into account the comfort parameters and the greatest wind pressure; the geometric shape of the outer contour affects the location of the zones of reduced comfort; a sharp change in the boundaries of the outer contour leads to the appearance of increased pressure and wind speed and, as a consequence, a change in the direction of the vortex flows; it is necessary to apply the finite element method when modeling the wind impact for buildings of complex geometric shapes; sudden changes in the object's contour should be avoided when designing buildings and structures

Towards sustainable development through bridging digital penetration gaps

The aim of the article is to study the impact of the digital environment on the economic conditions of economic entities, as well as to assess the gaps between economic development, changes in social relations and environmental well-being. It is proved that gaps in digital penetration can cause the deepening of existing inequalities and risks: digital inequality, social inequality, inequality in the appropriation of benefits, environmental risks. Approaches to assessing the impact of digital artifacts on the environment (in the context of the concept of "circular economy") and sustainable development of the economic system are investigate

The Problem of Competences Formation Level of Teachers in the Field of Inclusive Education Technologies for Children with Send

Статья посвящена изучению уровня сформированности компетенций в области технологий инклюзивного образования у педагогов общеобразовательных организаций Свердловской области.The article is devoted to the study of the level of formation of competences in the field of technologies of inclusive education among teachers of general education organizations of Sverdlovsk region and among future general education teachers

Disinfection of Surfaces Contaminated with SARS-CoV-2 Coronavirus by UV Radiation of Low-Pressure Mercury-Vapour Lamp

The aim of the work was to determine the effective ultraviolet (UV) doses required for the disinfection of surfaces contaminated with the SARS-CoV-2 coronavirus using a low-pressure mercury lamp. Materials and methods. To carry out prompt disinfection of surfaces, a specially designed source of UV radiation with a power of 7.5 W at a wavelength of 254 nm in the form of a portable flashlight was employed, which has a high efficiency of UV radiation output and the possibility of long-term autonomous operation from a compact battery. In the studies, a suspension culture of the SARS-CoV-2 coronavirus with biological activity of 5.3∙106 PFU/ml was used. The objects of testing were plastic Petri dishes (disposable) and office paper (grade C, density 80 g/m2 ). Results and discussion. Doses of UV radiation that provide disinfection of surfaces contaminated with the COVID-19 pathogen with an efficiency of 99.0 % (paper) to 99.95 % (plastic) have been determined. The results obtained make it possible to recommend a portable UV irradiator for use in the practice of preventive measures to combat the spread of the disease caused by the SARS-CoV-2 coronavirus

БИОПСИЯ СИГНАЛЬНЫХ ЛИМФАТИЧЕСКИХ УЗЛОВ ПРИ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ

За последние десятилетия в хирургическом лечении рака молочной железы появилась тенденция к органосохраняющему и все менее травматичному и калечащему этапу в многоступенчатой терапии этого заболевания. Выполнение подмышечной лимфодиссекции часто сопровождается такими осложнениями, как лимфостаз верхних конечностей, ограничение подвижности и болевые ощущения плечевого сустава, что, в ряде случаев, ведет к инвалидизации, при излечении от рака

PUNCHING CALCULATION OF REINFORCED CONCRETE FLOOR SLABS

Abstract. In this paper is considered the modeling of a monolithic reinforced concrete buildings structures by the spatial plate-core scheme and study of the floor slabs punching problem. When creating the finite element model of the building structure the floor slabs were created by four-node quadrilateral finite elements with 24 degrees of freedom, the columns and beams were created by spatial rods with 12 degrees of freedom. The calculation of the frame has been done by the software complex «SCAD», are got the efforts in the framework elements and are determined the concentration of stresses in the connections of slabs and columns. The program «Calculation of floor slab on punching» has been developed by the high-level language Object Pascal in Delphi environment, in accordance with the design standard which allows to research different locations of columns and stiffening diaphragms on the floor slab. The ratio of bearing capacity of the slab was calculated by means of the software «Calculation of floor slab on punching». Results are well correlated with the program «Arbat» of the software complex «SCAD». Difference of the developed program is in the possibility of considering of the columns and stiffness diaphragm location options on the floor slab (central, edge, corner). Program «Calculation of floor slab on punching» is recommended for use in the design of monolithic reinforced concrete structures

COMPARATIVE ANALYSIS OF DIFFERENT NEOADJUVANT CHEMOTHERAPY REGIMENS FOR TRIPLE-NEGATIVE BREAST CANCER

Background. Breast cancer is a heterogeneous disease with a variety of phenotypic forms. Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes characterized by high sensitivity to chemotherapy and early recurrence. Due to the lack of efficiency of standard therapeutic approaches, it appears extremely important to search for new regimens of neoadjuvant polychemotherapy (NAPCT). Objective: to assess the efficiency of different NAPCT regimens for treatment of stages T1N1–3 and T2–4N0–3 locally advanced TNBC and to compare the efficiency of eribulin and paclitaxel in NAPCT of TNBC.Materials and methods. A randomized prospective study to evaluate the efficacy of TNBC treatment is being conducted in the N.N. Petrov National Medical Research Center of Oncology since October, 2015. The study included 61 patients with a median age of 45 years (range 31–76 years). Study participants were treated with 2 different NAPCT regimens: patients in the 1st group received eribulin at a dose of 1.1 mg/m2 on the days 1 and 8 of a 21-day cycle in combination with carboplatin AUC6, patients in the 2nd group received paclitaxel at a dose of 80 mg/m2 on the days 1 and 8 of a 21-day cycle in combination with carboplatin AUC6. Then all patients underwent surgery in different volume (radical mastectomy, organ-preserving surgery, reconstructive plastic surgery) with subsequent FAC adjuvant chemotherapy.Results. So far, 61 patients have been randomized (further calculations are based on the number of operated patients: 24 in the 1st group and 27 in the 2nd group). During the preoperative stage, complete clinical regression was achieved in 11 patients from the 1st group and 15 patients from the 2nd group; partial clinical regression was observed in 13 and 12 patients in groups 1 and 2 respectively. We found that the therapeutic regimen with paclitaxel + carboplatin induced a higher rate of pathologic complete responses (ypCR). After NAPCT, 51 out of 61 patients (84 %) underwent surgical treatment. Pathomorphological examination showed that the frequency of pathologic complete response was 33 % (8 cases) in the 1st group compared to 60 % (16 cases) in the 2nd group. Five patients treated with eribulin + carboplatin developed distant metastases in bones, lungs, brain, postoperative scar and lymph nodes in the neck on average 4 months after surgery.Conclusions. Higher rate of ypCR was observed in patients received paclitaxel + carboplatin