REAL TIME REGISTRATION OF THE ELECTROPHYSIOLOGICAL SIGNALS SPECTRA

The paper deals with the issues of spectra acquisition for the electrophysiological signals, diagnostics result dependence on the noise level and expert’s qualification. A real-time module for amplitude-frequency spectra estimation of electrophysiological signals is designed. A general diagram of connection between measuring module and spectrum analyzer (as a part of multifunctional diagnostic system) is shown. The module is realized on the base of Cubieboard A20 minicomputer. It provides continuous decomposition of signals (up to 32 channels) into fragments of equal length and their independent mathematical processing for each measuring channel. The suggested device makes it possible to analyze the real-time dynamics of spectrum changes

The attitude of consumers to the instructions for medical use of the drug

This article presents the results of a sociological survey on the attitude of consumers to the instructions for medical use of the drug, which was attended by 52 respondents. According to the results of the survey, more than 80% of respondents try to comply with the requirements of the instruction, and the remaining 20% either partially comply or do not comply at all.В данной статье представлены результаты социологического опроса об отношении потребителей к инструкции по медицинскому применению лекарственного препарата, в котором участвовали 52 респондента. По итогам опроса было выявлено, что более 80% респондентов стараются соблюдать требования инструкции, а остальные 20% либо частично соблюдают, либо не соблюдают совсем

Study of marketing communications in the segment of dermatological medicines

The purpose of the study is to assess the degree of penetration of advertising into the promotion programs of individual groups of medicines.Цель исследования - оценить степень проникновения рекламы в программы продвижения отдельных групп ЛП

Approbation of a prognostic model of commodity turnover of a pharmacy organization on the example of the Sysert urban district

The purpose of the study is to test the predictive model of the turnover of a pharmacy organization on the example of the Sysert urban district.Цель исследования – апробация прогностической модели товарооборота аптечной организации на примере Сысертского городского округа

Resolution on the results of the First All-Russian Forum "Therapeutic Education in Endocrinology"

According to the decision of the WHO, therapeutic education (TE) of patients is an independent branch of medicine and an essential component of the treatment of chronic diseases, primarily diabetes mellitus and obesity. TE is implemented through the creation of “Schools for patients with diabetes mellitus” and “Schools for patients with overweight” (“Schools”) as a structural unit of a medical institution. On April 25–26, 2022, the First All-Russian Forum «Therapeutic Education in Endocrinology» was held online, organized by the Public Organization «Russian Association of Endocrinologists», which was attended by leading experts in this field. As a result of its work, this Resolution was adopted by the experts. It discusses the methodological and pedagogical foundations of TE, it is proposed to make changes related to the organization of the work of «Schools», tariffing in the obligatory health insurance system, and training of personnel, including nurses

Изменения гемоциркуляторных и респираторных функций при бронхиальной астме у детей

One hundred and fifty bronchial asthma patients aged 6 to 14 yrs were complexly examined for haemodynamic parameters in correlation with the lung function and the diaphragm activity in different stages of the disease. The respiratory dysfunction based on the bronchial obstruction, irregular lung ventilation and reduction in the diaphragm functional activity was shown to be accompanied by changes in the regional and central blood circulation. A consistency of these disorders depended on the basic therapyУ 150 больных бронхиальной астмой в возрасте от 6 до 14 лет проведено комплексное исследование параметров гемодинамики во взаимосвязи с оценкой функции внешнего дыхания и активности диафрагмы в различные периоды заболевания. Показано, что респираторная дисфункция, в основе которой лежат бронхиальная обструкция, неравномерная вентиляция легких и снижение функциональной активности диафрагмы, сочетается с изменениями регионарной и центральной гемоциркуляции. Причем стойкость отмеченных отклонений зависит от применения базисной терапии

Clinical, hormonal and molecular-genetic characteristics of monogenic diabetes mellitus associated with the mutations in the <i>INS</i> gene

Background: Currently more than 50 mutations of the INS gene are known to affect the various stages of insulin biosynthesis in the beta cells of the pancreas. However only individual cases of diabetes mellitus (DM) associated with heterozygous mutations in the coding region of the INS gene were reported in Russian Federation. We report a group of patients with a clinical manifestation of DM caused by mutations in both coding and non-coding regions of the INS gene. The patients with a mutation in the intron of the INS gene are reported for the first time in Russian FederationMaterials and methods: 60 patients with an isolated course of neonatal DM (NDM), 52 patients with a manifestation of DM at the age of 7–12 months and the absence of the main autoimmune markers of type 1 DM, 650 patients with the MODY phenotype were included in the study. NGS technology was used for molecular genetic research. Author’s panel of primers (Custom DNA Panel) was used for multiplex PCR and sequencing using Ion Ampliseq™ technology. The author’s panel “­Diabetes Mellitus” included 28 genes (13 candidate genes of MODY and other genes associated with DM).Results: 13 heterozygous mutations were identified in 16 probands and 9 relatives. The majority of mutations were detected in patients with PNDM (18.75%) and in patients with an onset of DM at the age of 7–12 months (9.6%). Mutations in the INS gene were detected in 2 patients (0.3%) in the group with the MODY phenotype. Mutations in the INS gene were not detected in patients with transient NDM (TNDM). Analysis of clinical data in patients with PND and onset of diabetes at the age of 7–12 months did not show significant differences in the course of the disease. The clinical characteristics of the cases of MODY10 and diabetes caused by a mutation in the intron of the INS gene are reported in details.Conclusion: The role of INS gene mutations in NDM, MODY, and DM with an onset at the age of 7–12 months was analyzed in a large group of patients. The clinical characteristics of DM due to a mutation in the intron of the INS gene are reported for the first time in the Russian Federation

Government intervention and financial sector development

Ye

УРОВЕНЬ sCD30 ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ ДЕТЯМ С ВРОЖДЕННЫМИ И НАСЛЕДСТВЕННЫМИ ЗАБОЛЕВАНИЯМИ ПЕЧЕНИ И ЖЕЛЧЕВЫВОДЯЩИХ ПУТЕЙ

Soluble CD30 (sCD30) is a marker of T-lymphocytes activation and is used for monitoring rejection in patients after heart, lung and renal transplantation. The aim of the study was to evaluate plasma levels of sCD30 in child- ren before and after living-donor liver transplantation (LDLT) and its relationship with the postoperative course. The study included 72 children with end-stage liver disease (ESLD), aged 17 ± 11 (4–28) months before and after LDLT, 15 healthy children aged 9.9 ± 5.7 (3–21) months and 38 adult living-related liver donors, aged 37 ± 19 (18–56) years. In children with ESLD pre-transplant plasma level of sCD30 (84,9 ± 43,8 ng/ml) was significantly higher than in healthy donors and healthy children (26.4 ± 12.0 and 32.6 ± 6.9 ng/ml, resp., p &lt; 0.01). After LDLT plasma level of sCD30 was higher in children, who had graft dysfunction at days 28–32 (108.9 ± 17.7 ng/ml) after LDLT than in children who had no graft dysfunction (40.2 ± 5.3 ng/ml, р &lt; 0.01). In patients with graft dysfunction elevation of sCD30 concentration was observed before 2–5 days increasing of liver enzyme activity. The measurement of sCD30 concentration may be useful for monitoring of the postoperative course. Растворимая форма CD30 (sCD30) является маркером активации Т-лимфоцитов, а измерение его уров- ня в плазме крови используется для мониторинга острого отторжения после трансплантации сердца, лег- кого и почки. Изучено содержание sCD30 в плазме крови детей до и после родственной трансплантации фрагмента печени и связь его динамики с течением послеоперационного периода. В исследование включено 72 ребенка с терминальной стадией заболеваний печени в возрасте 17 ± 11 (4–28) месяцев, 15 здоровых детей в возрасте 9,9 ± 5,7 (3–21) и 38 доноров фрагмента печени в возрасте 37 ± 19 (18–56) лет. Уровень sCD30 у детей до трансплантации (84,9 ± 43,8 нг/мл) был значительно выше, чем у доноров и здоровых детей (26,4 ± 12,0 и 32,6 ± 6,9 нг/мл соответственно, р &lt; 0,01). Уровень sCD30 в плазме крови реципиентов с клиническими и биохимическими признаками дисфункции транспланта- та, развившейся на 28–32-е сутки после трансплантации (108,9 ± 17,7 нг/мл), был выше, чем у реципи- ентов без осложнений (40,2 ± 5,3 нг/мл, p &lt; 0,01). У всех реципиентов с дисфункцией трансплантата по- вышение уровня sCD30 обнаружено за 2–5 дней до появления роста активности ферментов печени. Из- мерение концентрации sCD30 у реципиентов печени целесообразно для мониторинга течения посттран- сплантационного периода.