Hierarchy and Competition in CSCW applications: Model and case study

CSCW applications need to adapt themselves to the functional and organizational structures of people that use them. However they do not usually support division in groups with a certain hierarchical structure among them. In this paper, we propose and study a theoretical model of groupware appliations that reflects those hierarchical interactions. The proposed model is also intended to evaluate the effects in performance derived from competitive and collaborative relationships among the components of a hierarchy of groups. In order to demonstrate the above ideas, a groupware game, called Alymod, was designed and implemented using a modified version of a well-known CSCW Toolkit, namely Groupkit. Groupkit was modified in order to support group interactions in the same CSCW application. In Alymod, participants compete or collaborate within a hierarchical structure to achieve a common goal (completing gaps in a text, finishing numerical series, resolving University course examinations, etc.).Publicad

Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space

The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easier to find sequences that satisfy the "Principle of Minimal Frustration" when the folded structure is symmetric (Wolynes, P. G. Symmetry and the Energy Landscapes of Biomolecules. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 14249-14255). Similarly, repeats and structural mosaics may be fundamentally related to landscapes with multiple embedded funnels. Here we present analytical tools to detect and compare structural repetitions in protein molecules. By an exhaustive analysis of the distribution of structural repeats using a robust metric we define those portions of a protein molecule that best describe the overall structure as a tessellation of basic units. The patterns produced by such tessellations provide intuitive representations of the repeating regions and their association towards higher order arrangements. We find that some protein architectures can be described as nearly periodic, while in others clear separations between repetitions exist. Since the method is independent of amino acid sequence information we can identify structural units that can be encoded by a variety of distinct amino acid sequences

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation

Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS. Therefore, compromised function of brain endothelial cells has serious consequences for BBB integrity. This has been associated with early events in the pathogenesis of several disorders that affect the CNS, such as multiple sclerosis, HIV-associated neurologic disorder, and stroke. Recent studies demonstrate that brain endothelial microRNAs play critical roles in the regulation of BBB function under normal and neuroinflammatory conditions. This review will focus on emerging evidence that indicates that brain endothelial microRNAs regulate barrier function and orchestrate various phases of the neuroinflammatory response, including endothelial activation in response to cytokines as well as restoration of inflamed endothelium into a quiescent state. In particular, we discuss novel microRNA regulatory mechanisms and their contribution to cellular interactions at the neurovascular unit that influence the overall function of the BBB in health and during neuroinflammatio

Dielectric branes in non-trivial backgrounds

We present a procedure to evaluate the action for dielectric branes in non-trivial backgrounds. These backgrounds must be capable to be taken into a Kaluza-Klein form, with some non-zero wrapping factor. We derive the way this wrapping factor is gauged away. Examples of this are AdS_5xS^5 and AdS_3xS^3xT^4, where we perform the construction of different stable systems, which stability relies in its dielectric character.Comment: 14 pages, published versio

Phase transitions in social sciences: two-populations mean field theory

A new mean field statistical mechanics model of two interacting groups of spins is introduced and the phase transition studied in terms of their relative size. A jump of the average magnetization is found for large values of the mutual interaction when the relative percentage of the two populations crosses a critical threshold. It is shown how the critical percentage depends on internal interactions and on the initial magnetizations. The model is interpreted as a prototype of resident-immigrant cultural interaction and conclusions from the social sciences perspectives are drawn

A Period and a Prediction for the Of?p Spectrum Alternator HD 191612

The observational picture of the enigmatic O-type spectrum variable HD191612 has been sharpened substantially. A symmetrical, low-amplitude light curve with a period near 540 d has recently been reported from Hipparcos photometry. This period satisfies all of the spectroscopy since at least 1982, including extensive new observations during 2003 and 2004, and it has predicted the next transition during September--October 2004. Measurements of the H alpha equivalent width reveal a sharp emission peak in the phase diagram, in contrast to the apparently sinusoidal light curve. The He II absorption-line strength is essentially constant, while He I varies strongly, possibly filled in by emission in the O6 state, thus producing the apparent spectral-type variations. The O8 state appears to be the "normal" one. Two intermediate O7 observations have been obtained, which fall at the expected phases, but these are the only modern observations of the transitions so far. The period is too long for rotation or pulsation; although there is no direct evidence as yet for a companion, a model in which tidally induced oscillations drive an enhanced wind near periastron of an eccentric orbit appears promising. Further observations during the now predictable transitions may provide a critical test. Ultraviolet and X-ray observations during both states will likely also prove illuminating.Comment: 7 pages, 3 figures, 1 table; scheduled for the 2004 December 10 issue of ApJL, Vol. 617, No. 1. ApJ

Constraining the Kahler Moduli in the Heterotic Standard Model

Phenomenological implications of the volume of the Calabi-Yau threefolds on the hidden and observable M-theory boundaries, together with slope stability of their corresponding vector bundles, constrain the set of Kaehler moduli which give rise to realistic compactifications of the strongly coupled heterotic string. When vector bundles are constructed using extensions, we provide simple rules to determine lower and upper bounds to the region of the Kaehler moduli space where such compactifications can exist. We show how small these regions can be, working out in full detail the case of the recently proposed Heterotic Standard Model. More explicitely, we exhibit Kaehler classes in these regions for which the visible vector bundle is stable. On the other hand, there is no polarization for which the hidden bundle is stable.Comment: 28 pages, harvmac. Exposition improved, references and one figure added, minor correction

Building Cooperative Networks

We study the cooperation problem in the framework of evolutionary game theory using the prisoner's dilemma as metaphor of the problem. Considering the growing process of the system and individuals with imitation capacity, we show conditions that allow to form highly cooperative networks of any size and topology. Introducing general considerations of real systems, we reduce the required conditions for cooperation to evolve approaching the benefit-cost ratio r to the theoretical minimum r=1, when the mean connectivity of the individuals is increased. Through the paper, we distinguish different mechanisms that allow the system to maintain high levels of cooperation when the system grows by incorporation of defectors. These mechanisms require heterogeneity among individuals for cooperation to evolve. However, the required conditions and heterogeneities are drastically reduced as compared to those required for static networks.Comment: 24 pages, 8 figure