Comparative analysis of self-assessment and objective state of health in students of junior courses of medical and humanitarian specialties

Aim of the study was to determine the level of self-assessment of health-related quality of life (HRQoL) and its relationship with the objective state of health in students of junior courses of medical and humanitarian specialties.Materials and methods. The study has been conducted at the Far Eastern Federal University (FEFU) and at the Pacific State Medical University (TSMU) since December 10, 2017 to June 10, 2018. It was attended by 479 students of junior (1-3) courses, of which 228 (47.5 %) studied medical specialties at FEFU and TSMU, 251 (52.5 %) studied humanitarian specialties (FEFU). The average age of students was 19.5 ± 1.9 years, the average response rate - 94.2 %. The selection was carried out using the principles of gender-stratified randomization. The state of health of the students was assessed by the presence of chronic diseases and the level of the Charlson comorbidity index. In the collection of data used outpatient cards (Form 025/y); patient registration logs (Form 001-1/y); medical control cards of followup (Form 062/y). For the self-assessment of HRQoL, a questionnaire was used: «A short form of self-assessment of HRQoL, MOS SF-36v2» (Medical Outcomes Study Short Form version 2). The demographic and socio-economic status was determined using a special questionnaire.Results and discussion. HRQoL indicator in medical students turned out to be related to the frequency of seeking medical help (r = 0.75; p < 0.01), the comorbidity index (r = 0.43; p < 0.05) and the average number of chronic diseases among respondents (r = 0.49; p < 0.05). The relationship between the total HRQoL and the physical and mental components of QoL self-assessment also proved to be quite strong (r = 0.69; p < 0.01; r = 0.59; p < 0.01, respectively). In students of humanitarian specialties HRQoL appeared (in addition to the physical and mental component of QoL) to be interrelated only with the average number of chronic diseases (r = 0.69; p < 0.05). Thus, 76,0 % of students of medical and humanitarian specialties have undergone chronic diseases of internal organs in junior courses. Diseases of the digestive (30-33 %), urogenital (10-14 %), respiratory (7-10 %) and nervous systems (6-10 %) are most common in the student environment. HRQoL in the students of junior courses of medical and humanitarian specialties does not significantly differ and is rated by them as satisfactory

First national survey of anti-tuberculosis drug resistance in Azerbaijan and risk factors analysis.

SETTING: Civilian population of the Republic of Azerbaijan. OBJECTIVES: To determine patterns of anti-tuberculosis drug resistance among new and previously treated pulmonary tuberculosis (TB) cases, and explore their association with socio-demographic and clinical characteristics. DESIGN: National cross-sectional survey conducted in 2012-2013. RESULTS: Of 789 patients (549 new and 240 previously treated) who met the enrolment criteria, 231 (42%) new and 146 (61%) previously treated patients were resistant to any anti-tuberculosis drug; 72 (13%) new and 66 (28%) previously treated patients had multidrug-resistant TB (MDR-TB). Among MDR-TB cases, 38% of new and 46% of previously treated cases had pre-extensively drug-resistant TB (pre-XDR-TB) or XDR-TB. In previously treated cases, 51% of those who had failed treatment had MDR-TB, which was 15 times higher than in relapse cases (OR 15.2, 95%CI 6-39). The only characteristic significantly associated with MDR-TB was a history of previous treatment (OR 3.1, 95%CI 2.1-4.7); for this group, history of incarceration was an additional risk factor for MDR-TB (OR 2.8, 95%CI 1.1-7.4). CONCLUSION: Azerbaijan remains a high MDR-TB burden country. There is a need to implement countrywide control and innovative measures to accelerate early diagnosis of drug resistance in individual patients, improve treatment adherence and strengthen routine surveillance of drug resistance

Objective and subjective health indicators, associated with successful teaching students of younger courses of medical specialties

Objective: То study the relationship of performance with self-esteem of physical and mental health and the objective state of morbidity, taking into account the influence of demographic and socio-economic parameters of undergraduate medical students. Materials and methods: The study was conducted from 15.011.2017 to 15.06.2018 at the Far-Eastern Federal University and the Pacific State Medical University, 299 students took part in it 146 (48.8%) were male, and 153 (51.2%) were female, the average age was 21,2 (1.7) years. The average response rate was 94,8%. In the course of the study, the students independently answered the questionnaire of the self-assessment of the demographic, socioeconomic, medical, and behavioral status of a university student; Statistical analysis of the information obtained was carried out using the program ‘Statistica 6.0'. Result: The composite assessment of the KHSSS by the students of FEFU and TSMU practically coincided: 63.4 / 61.3 points (p 0.05). Taking into account the contribution of each parameter to the regression model, the performance was associated with the assessment of the conditions of learning and living (for the FVHU students: r = 0.035 (0.016), p <0.05; r = 0.061 (0.018), p <0.01; for the TSMU students (r = 0.038 (0.024), p <0.05; r = 0.078 (0.017), p <0.01)). In the combined sample, the strongest correlation was found between academic performance and the level of living and training conditions (11.31 (5.91-19.39), p <0.01); quality of life related to health (11.54 (5.23-17.32), p <0.01); the level of family income (5.93 (1.55-10.27), p <0.01) and a number of other indicators. Conclusion: The self-esteem of lifecycle health in young undergraduate medical students enrolled in FEFU and TSMU is in the range of normal values. The regression analysis conducted in the combined sample demonstrates a correlation between the learning success rate index and the KJVP scores, the conditions of learning and living, the quality of learning, the comorbidity index and the level of family income.Цель: Исследование взаимосвязи успеваемости с самооценкой физического и психического здоровья и объективным состоянием заболеваемости, с учетом влияния демографических и социально-экономических параметров у студентов младших курсов медицинских специальностей. Материалы и методы: Исследование проводилось с 15.011.2017 по 15.06.2018 года в Дальневосточном федеральном университете и в Тихоокеанском Государственном медицинском университете, в нем приняли участие 299 студентов: 146 (48,8 %) мужского, и 153 (51,2%) женского пола, средний возраст составил 21,2 (1,7) года. Средняя частота отклика составила 94,8%. В процессе исследовании студенты самостоятельно отвечали на вопросы анкеты самооценки демографического, социально-экономического, медицинского и поведенческого статуса студента ВУЗа, индекс коморбидности рассчитывался по данным первичной медицинской документации (формы 025/у; 001-1/У; 062/у). Статистический анализ полученной информации был проведен с использованием программы «Statistica 6.0». Результат Композитная оценка КЖСЗ студентами ДВФУ и ТГМУ практически совпадала: 63,4/61,3 балла (р 0.05). С учетом вклада каждого параметра в модель регрессии успеваемость оказалась связанной с оценкой условий обучения и проживания (у студентов ДФВУ: г= 0,035 (0,016), р<0.05; г= 0,061 (0,018), р<0.01; у студентов ТГМУ (г= 0,038 (0,024), р<0.05; г= 0,078 (0,017), р<0.01)). В объединенной выборке наиболее сильную взаимосвязь удалось обнаружить между успеваемостью и уровнем условий проживания и обучения (11.31 (5.91-19.39), р<0.01); качеством жизни связанным со здоровьем (11.54 (5.23-17.32), р<0.01); уровнем семейного дохода (5.93 (1.55-10.27), р<0.01) и рядом других показателей. Выводы: Самооценка КЖСЗ у студентов младших курсов медицинских специальностей, обучающихся в ДВФУ и ТГМУ находится в диапазоне нормальных значений. Регрессионный анализ, проведенный в объединенной выборке, демонстрирует корреляцию показателя успешности обучения с оценками КЖСЗ, условий обучения и проживания, качества обучения, индексом коморбидности и уровнем семейного дохода

Лапароскопическая радикальная нефрэктомия с тромбэктомией из нижней полой вены I - III уровня: опыт одного центра и обзор литературы.

Objective. Radical nephrectomy with thrombectomy of the inferior vena cava is the preferred treatment for renal cell carcinoma with an tumor thrombosis. We describe our experience and presentreview of the literature evaluating the feasibility and safety of laparoscopic nephrectomy with inferior vena cava thrombectomy.Materials and methods. The study included 37 patients who underwent laparoscopic radical nephrectomy with level I–III thrombectomy for renal cell carcinoma in our institution from 2018 to 2021. We analyzed the clinical, radiographic, intraoperative, pathological and postoperative parameters of the patients. The literature was reviewed by the Medline search engine, PubMed, with a review of publications on laparoscopic radical nephrectomy with inferior vena cava levelI–IIIthrombectomy.Results. The mean operation time was 275 ± 60.1 min, the median blood loss was 450 ± 81.6 ml (≥50 % of the circulating blood volume – 32.4 %). Intraoperative complications were observed during 10 (27.0 %) operations. Postoperative complications developed in 29.7 % of patients and reached gradesIII–IV according to the Clavien–Dindo scale on 13.0 % ill. All patients are activated according to the fast track rehabilitation program. The average hospital stay was 5 days. A literature review identified clinical cases and small series demonstrating the technical feasibility and safety of laparoscopic radical nephrectomy with thrombectomy in selected patients.Conclusion. Laparoscopic radical nephrectomy with thrombectomy is a technically feasible approach in carefully selected patients with level I–III tumor thrombosis. Optimal patient selection, extensive experience in laparoscopy and specialized centers are essential for the safe use of thistechnique.Цель исследования – представить непосредственные результаты выполнения лапароскопической радикальной нефрэктомии с тромбэктомией из нижней полой вены I–III уровней в условиях одного онкоурологического стационара.Материалы и методы. В исследование были включены 37 пациентов, перенесших лапароскопическую радикальную нефрэктомию с тромбэктомией из нижней полой вены I–III уровней по поводу почечно-клеточного рака в НМИЦ онкологии им. Н.Н. Петрова в период с 2018 по 2021 г. Проанализированы клинические, рентгенографические, интраоперационные, патоморфологические и послеоперационные параметры пациентов. В системах Medline и PubMed выполнен поиск публикаций, посвященных лапароскопической радикальной нефрэктомии с тромбэктомией из нижней полой вены I–III уровней за последние 10 лет.Результаты. Среднее время операции составило 275 ± 60,1 мин, медиана объема кровопотери – 450 ± 81,6 мл (≥50 % объема циркулирующей крови – 32,4 %). Интраоперационные осложнения отмечены в 10 (27,0 %) случаях. Послеоперационные осложнения развились у 29,7 % пациентов и достигли III–IV степеней тяжести по шкале Clavien–Dindo у 13,0 % больных. Все пациенты активизированы по программе ускоренной реабилитации fast track. Средняя продолжительность пребывания в стационаре составила 5 сут. Обзор литературы выявил клинические случаи и небольшие серии, демонстрирующие техническую осуществимость и безопасность лапароскопической радикальной нефрэктомии с тромбэктомией у отдельных пациентов.Заключение. Лапароскопическая радикальная нефрэктомия с тромбэктомией – технически осуществимый подход у тщательно отобранных пациентов с опухолевым тромбом I–III уровней. Оптимальный отбор пациентов, обширный опыт лапароскопии и специализированные центры являются принципиальными элементами для безопасного применения этого метода

DETECTION OF OIL POLLUTION HOTSPOTS AND LEAK SOURCES THROUGH THE QUANTITATIVE ASSESSMENT OF THE PERSISTENCE AND TEMPORAL REPETITION OF REGULAR OIL SPILLS IN THE CASPIAN SEA USING REMOTE SENSING AND GIS

The main goal of this research was to detect oil spills, to determine the oil spill frequencies and to approximate oil leak sources around the Oil Rocks Settlement, the Chilov and Pirallahi Islands in the Caspian Sea using 136 multi-temporal ENVISAT Advanced Synthetic Aperture Radar Wide Swath Medium Resolution Images acquired during 2006-2010. The following oil spill frequencies were observed around the Oil Rocks Settlement, the Chilov and Pirallahi Islands: 2-10 (3471.04 sq. km.), 11-20 (971.66 sq. km.), 21-50 (692.44 sq. km.), 51-128 (191.38 sq. km.). The most critical oil leak sources with the frequency range of 41-128 were observed at the Oil Rocks Settlement. The exponential regression analysis between wind speeds and oil slick areas detected from 136 multi-temporal ENVISAT images revealed the regression coefficient equal to 63%. The regression model showed that larger oil spill areas were observed with decreasing wind speeds. The spatiotemporal patterns of currents in the Caspian Sea explained the multi-directional spatial distribution of oil spills around Oil Rocks Settlement, the Chilov and Pirallahi Islands. The linear regression analysis between detected oil spill frequencies and predicted oil contamination probability by the stochastic model showed the positive trend with the regression coefficient of 30%

NPHS2 gene sequencing results in children of the Azerbaijani population with different types of nephrotic syndrome caused by chronic glomerulonephritis

WOS: 000459055600002PubMed ID: 30793612OBJECTIVES: The aim of the study was to determine the mutation of the podocin gene (NPHS2) in children with minimal changes diseases (steroid sensitive nephrotic syndrome (NS)) and steroid resistant NS. BACKGROUND: Despite the fact that the role of genetic factors is a well-known phenomenon, in NS there are still unknown aspects that are yet to be discovered. NS, type 2 is caused by NPHS2 gene and is characterised with proteinuria, minimal change disease on renal biopsy, poor response to steroid treatment, etc. METHODS: Twenty-nine children (65.5 % male, 34.5 % female) with nephrotic syndrome caused by chronic glomerulonephritis were examined and patients were tested for NPHS2 gene with Sanger technique. RESULTS: The average age was 7.2 +/- 2.65 years. 82.8 % of patients had NS with minimal changes, 17.2 % had a steroid resistant NS. The analysis of the NPHS2 gene revealed a likely pathogenic (Arg168His), uncertain significance (Pro20Ley, Leu169Pro, Val180Met, Arg229Gln, Val290Met) and benign (Gly34Gly, Ala318Ala) variants. No novel variants were detected. CONCLUSION: This is the first study investigating the nephrotic syndrome related to NPHS2 gene in Azerbaijani population. The high prevalence of uncertain significance variants emphasises the importance of population studies in this region as such data are necessary for classifications of the detected genetic variants (Tab. 1, Ref. 25). Text in PDF www.elis.sk

NMR studies of some 4-hydroxy-2-methylacetophenone thiosemicarbazones in solutions

1518-1527Molecular dynamics of (E)-4-hydroxy-2-methylacetophenone thiosemicarbazone and (E,E)-3-(5-bromo-2-hydroxyphenyl)-1-(4-hydroxy-2-methylphenyl)prop-2-en-1-one thio­semi­car­­ba­zone have been investigated in solution using NMR. The results confirm the presence of con­for­mational transitions in the <span style="mso-bidi-font-family: " times="" new="" roman";mso-ansi-language:az-latin"="" lang="AZ-LATIN">investigated molecules. The rotational barrier energy for the con­for­ma­tional transitions has been calculated. </span