117 research outputs found
Tetrabutylammonium methacrylate as a novel receptor for selective extraction of sulphonylurea drugs from biological fluids using molecular imprinting
Tetrabutylammonium methacrylate introduced as functional monomer for the stoichiometric imprinting of sulfonylurea drug glibenclamide.</p
Lathe converted for grinding aspheric surfaces
A standard overarm tracing lathe converted by the addition of an independently driven diamond grinding wheel is used for grinding aspheric surfaces. The motion of the wheel is controlled by the lathe air tracer following the template which produces the desired aspheric profile
“That’s not what you expect to do as a doctor, you know, you don’t expect your patients to die.” Death as a learning experience for undergraduate medical students
MKS3/TMEM67 mutations are a major cause of COACH syndrome, a joubert syndrome related disorder with liver involvement
The acronym COACH defines an autosomal recessive condition of Cerebellar vermis hypo/
aplasia, Oligophrenia, congenital Ataxia, Coloboma and Hepatic fibrosis. Patients present the
“molar tooth sign”, a midbrain-hindbrain malformation pathognomonic for Joubert Syndrome (JS) and Related Disorders (JSRDs). The main feature of COACH is congenital hepatic fibrosis (CHF), resulting from malformation of the embryonic ductal plate. CHF is invariably found also in Meckel syndrome (MS), a lethal ciliopathy already found to be allelic with JSRDs at the CEP290 and RPGRIP1L genes. Recently, mutations in the MKS3 gene (approved symbol TMEM67), causative of about 7% MS cases, have been detected in few Meckel-like and pure JS patients. Analysis of MKS3 in 14 COACH families identified mutations in 8 (57%). Features such as colobomas and nephronophthisis were found only in a subset of mutated cases. These data confirm COACH as a distinct JSRD subgroup with core features of JS plus CHF, which major gene is MKS3, and further strengthen gene-phenotype correlates in JSRDs
The Neotethyan Sanandaj‐Sirjan zone of Iran as an archetype for passive margin‐arc transitions
Preliminary report on Lower Jurassic radiolaria of Gondwana origin from the Kawhia coast, New Zealand
Early Cretaceous tectonic events implied in the time-lag between the age of radiolarian chert and its metamorphic basement in the Bantimala area, South Sulawesi, Indonesia
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