72 research outputs found
ICTs connecting global citizens, global dialogue and global governance. A call for needful designs
Humankind is on the transition to a supra-system of humanity, according
to which social relationships – that organise the common good – are re-organised
such that global challenges are kept below the threshold of a self-inflicted
breakdown. In order to succeed, three conditions are imperative: (1) Global governance
needs a global conscience that orients towards the protection of the common
good. (2) Such global governance needs a global dialogue on the state of
the common good and the ways to proceed. (3) Such a global dialogue needs
global citizens able to reflect upon the current state of the common good and the
ways to proceed to desired states. Each of these imperatives is about a space of
possibilities. Each space nests the following one such that they altogether form
the scaffolding along which institutions can emerge that realise the imperatives
when proper nuclei are introduced in those spaces. Such nuclei would already
support each other. However, the clue is to further their integration by Information
and Communication Technologies. An information platform shall be
launched that could cover any task on any of the three levels, entangled with the
articulation of cooperative action from the local to the global, based on the cybersubsidiarity
model. This model is devised to ensure the percolation of meaningful
information throughout the different organisational levels.2019-2
Ăśber eine Klasse polynomialer Scharen selbstadjungierter Operatoren im Hilbertraum
HEK293A cells expressing either mouse MOG (mMOG) or rat MOG (rMOG) C terminally tagged with EGFP. (DOCX 2792Ă‚Â kb
Neurological update: MOG antibody disease
Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOG-AD) is now recognised as a nosological entity with specific clinical and paraclinical features to aid early diagnosis. Although no age group is exempt, median age of onset is within the fourth decade of life, with optic neuritis being the most frequent presenting phenotype. Disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. Residual disability develops in 50–80% of patients, with transverse myelitis at onset being the most significant predictor of long-term outcome. Recent advances in MOG antibody testing offer improved sensitivity and specificity. To avoid misdiagnosis, MOG antibody testing should be undertaken in selected cases presenting clinical and paraclinical features that are felt to be in keeping with MOG-AD, using a validated cell-based assay. MRI characteristics can help in differentiating MOG-AD from other neuroinflammatory disorders, including multiple sclerosis and neuromyelitis optica. Cerebrospinal fluid oligoclonal bands are uncommon. Randomised control trials are limited, but observational open-label experience suggests a role for high-dose steroids and plasma exchange in the treatment of acute attacks, and for immunosuppressive therapies, such as steroids, oral immunosuppressants and rituximab as maintenance treatment
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