Irreversible Specialization for Speech Perception in Early International Adoptees

In early childhood, the human brain goes through a period of tuning to native speech sounds but retains remarkable flexibility, allowing the learning of new languages throughout life. However, little is known about the stability over time of early neural specialization for speech and its influence on the formation of novel language representations. Here, we provide evidence that early international adoptees, who lose contact with their native language environment after adoption, retain enhanced sensitivity to a native lexical tone contrast more than 15 years after being adopted to Sweden from China, in the absence of any pretest familiarization with the stimuli. Changes in oscillatory brain activity showed how adoptees resort to inhibiting the processing of defunct phonological representations, rather than forgetting or replacing them with new ones. Furthermore, neurophysiological responses to native and nonnative contrasts were not negatively correlated, suggesting that native language retention does not interfere with the acquisition of adoptive phonology acquisition. These results suggest that early language experience provides strikingly resilient specialization for speech which is compensated for through inhibitory control mechanisms as learning conditions change later in life

Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus

Hantaviruses have previously been recognised to cause two separate syndromes: hemorrhagic fever with renal syndrome in Eurasia, and hantavirus pulmonary syndrome (HPS) in the Americas. However, increasing evidence suggests that this dichotomy is no longer fruitful when recognising human hantavirus disease and understanding the pathogenesis. Herein are presented three cases of severe European Puumala hantavirus infection that meet the HPS case definition. The clinical and pathological findings were similar to those found in American hantavirus patients. Consequently, hantavirus infection should be considered as a cause of acute respiratory distress in all endemic areas worldwide

Tunable variation of optical properties of polymer capped gold nanoparticles

Optical properties of polymer capped gold nanoparticles of various sizes (diameter 3-6 nm) have been studied. We present a new scheme to extract size dependent variation of total dielectric function of gold nanoparticles from measured UV-Vis absorption data. The new scheme can also be used, in principle, for other related systems as well. We show how quantum effect, surface atomic co - ordination and polymer - nanoparticle interface morphology leads to a systematic variation in inter band part of the dielectric function of gold nanoparticles, obtained from the analysis using our new scheme. Careful analysis enables identification of the possible changes to the electronic band structure in such nanoparticles.Comment: 13 pages,7 figures, 1 tabl

Salivary Biomarkers and Oral Health in Liver Transplant Recipients, with an Emphasis on Diabetes : Salivary biomarkers in liver transplant recipients

Salivary biomarkers have been linked to various systemic diseases. We examined the association between salivary biomarkers, periodontal health, and microbial burden in liver transplant (LT) recipients with and without diabetes, after transplantation. We hypothesized that diabetic recipients would exhibit impaired parameters. This study included 84 adults who received an LT between 2000 and 2006 in Finland. Dental treatment preceded transplantation. The recipients were re-examined, on average, six years later. We evaluated a battery of salivary biomarkers, microbiota, and subjective oral symptoms. Periodontal health was assessed, and immunosuppressive treatments were recorded. Recipients with impaired periodontal health showed higher matrix metalloproteinase-8 (MMP-8) levels (p < 0.05) and MMP-8/tissue inhibitor of matrix metalloproteinase 1 (TIMP1) ratios (p < 0.001) than recipients with good periodontal health. Diabetes post-LT was associated with impaired periodontal health (p < 0.05). No difference between groups was found in the microbial counts. Salivary biomarker levels did not seem to be affected by diabetes. However, the advanced pro-inflammatory state induced by and associated with periodontal inflammation was reflected in the salivary biomarker levels, especially MMP-8 and the MMP-8/TIMP-1 molar ratio. Thus, these salivary biomarkers may be useful for monitoring the oral inflammatory state and the course of LT recipients.Peer reviewe

Tokamak cooling systems and power conversion system options

DEMO will be a fusion power plant demonstrating the integration into the grid architecture of an electric utility grid. The design of the power conversion chain is of particular importance, as it must adequately account for the specifics of nuclear fusion on the generation side and ensure compatibility with the electric utility grid at all times. One of the special challenges the foreseen pulsed operation, which affects the operation of the entire heat transport chain. This requires a time-dependant analysis of different concept design approaches to ensure proof of reliable operation and efficiency to obtain nuclear licensing. Several architectures of Balance of Plant were conceived and developed during the DEMO Pre-Concept Design Phase in order to suit needs and constraints of the in-vessel systems, with particular regard to the different blanket concepts. At this early design stage, emphasis was given to the achievement of robust solutions for all essential Balance of Plant systems, which have chiefly to ensure feasible and flexible operation modes during the main DEMO operating phases – Pulse, Dwell and ramp-up/down – and to adsorb and compensate for potential fusion power fluctuations during plasma flat-top. Although some criticalities, requiring further design improvements were identified, these preliminary assessments showed that the investigated cooling system architectures have the capability to restore nominal conditions after any of the abovementioned cases and that the overall availability could meet the DEMO top-level requirements. This paper describes the results of the studies on the tokamak coolant and Power Conversion System (PCS) options and critically highlights the aspects that require further work

Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms

Several studies have identified obesity as a risk factor for asthma in both children and adults. An increased prevalence of asthma in subjects with gastro-oesophageal reflux (GOR) and obstructive sleep apnoea syndrome has also been reported. The aim of this investigation was to study obesity, nocturnal GOR and snoring as independent risk factors for onset of asthma and respiratory symptoms in a Nordic population. In a 5-10 yr follow-up study of the European Community Respiratory Health Survey in Iceland, Norway, Denmark, Sweden and Estonia, a postal questionnaire was sent to previous respondents. A total of 16,191 participants responded to the questionnaire. Reported onset of asthma, wheeze and night-time symptoms as well as nocturnal GOR and habitual snoring increased in prevalence along with the increase in body mass index (BMI). After adjusting for nocturnal GOR, habitual snoring and other confounders, obesity (BMI >30) remained significantly related to the onset of asthma, wheeze and night-time symptoms. Nocturnal GOR was independently related to the onset of asthma and in addition, both nocturnal GOR and habitual snoring were independently related to onset of wheeze and night-time symptoms. This study adds evidence to an independent relationship between obesity, nocturnal gastro-oesophageal reflux and habitual snoring and the onset of asthma and respiratory symptoms in adults