Motivation and labor values of youth: Development paradoxes

Based on the monitoring studies conducted in Tyumen oblast (2006—2016), the paper aims to examine trends and specifics of the development of labor orientations. Correlation and dispersion analysis is used to single out a number of inconsistencies reflecting immaturity of the market motivation and entrepreneurial orientation among those who were born and brought up in a market environment. Young persons with a more market-oriented type of labor motivation have fewer claims and agree to have the little they have if guarantees of stability are provided. The age when there is a break in the dominance of success and achievement motivation declines. Young people pay less attention to interesting and meaningful job. A gap between the declared value of initiative and entrepreneurship and a real commitment to creation of innovations are observed. Those who were born and raised in a market environment are eager to work «in the market». With a very high percentage of young people willing to work for themselves the share of actual young entrepreneurs is still very low. © 2018 Russian Public Opinion Research Center, VCIOM. All rights reserved

The analysb of infusion's assortment in the resuscitation and intensive care unit

The big portion of outlay for drugs purchase falls to share of infusion solutions. The assortment analysis of infusions, used in the resuscitation and intensive care unit, is showed in the article

Situational analysis of the unitary enterprise segment within the pharmaceutical market

The article discusses the analysis of the segment of unitary enterprises in the pharmaceutical market. A situational analysis of the diversification of pharmaceutical activities of registered unitary pharmaceutical enterprises is carried out.В статье обсуждается анализ сегмента унитарных предприятий в рамках фармацевтического рынка. Проведен ситуационный анализ диверсификации фармацевтической деятельности зарегистрированных унитарных фармацевтических предприятий. статье обсуждается анализ сегмента унитарных предприятий в рамках фармацевтического рынка. Проведен ситуационный анализ диверсификации фармацевтической деятельности зарегистрированных унитарных фармацевтических предприятий

The attitude of consumers to the instructions for medical use of the drug

This article presents the results of a sociological survey on the attitude of consumers to the instructions for medical use of the drug, which was attended by 52 respondents. According to the results of the survey, more than 80% of respondents try to comply with the requirements of the instruction, and the remaining 20% either partially comply or do not comply at all.В данной статье представлены результаты социологического опроса об отношении потребителей к инструкции по медицинскому применению лекарственного препарата, в котором участвовали 52 респондента. По итогам опроса было выявлено, что более 80% респондентов стараются соблюдать требования инструкции, а остальные 20% либо частично соблюдают, либо не соблюдают совсем

MODY caused by a mutation in the insulin gene

MODY10 is a rare subtype of MODY diabetes, which caused by heterozygous mutations in the insulin gene INS. There are single descriptions of families with MODY-INS or MODY10 in the literature, its clinical course is not well understood. We present a case of MODY10 in a boy with a history of diabetes mellitus (DM) in three generations (father and paternal grandmother). Proband was diagnosed with diabetes mellitus at the age of 7 years. The glycaemia at the onset of the diabetes was 10.2 mmol/l, HbA1c — 7.6%, islet cell autoantibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADA) and islet tyrosine phosphatase 2 (IA2) antibodies (IA2) were not detected. According to the results of the oral glucose tolerance test, fasting blood glucose was 6.5 mmol/l, in 120 minutes 10.3 mmol/l, which corresponded to the diagnosis of impaired glucose tolerance. Diet with restriction of easily digestible carbohydrates was recommended, than gliclazide was added to the therapy, which the proband received for 3 years. At the age of 10, a deterioration in the parameters of carbohydrate metabolism was noted, which insulin therapy was added. Examination at the age of 12 revealed a decrease in C-peptide secretion. The child’s father has a similar phenotype — slowly progressive disorders of carbohydrate metabolism from 6 years old, from 10 years old — insulin therapy. A genetic test was provided, in the child and his father was detected a previously undescribed heterozygous mutation in the INS p.C31W. Thus, in our clinical case, MODY10 was characterized by a milder course than T1DM, but eventually leading to the development of insulin demand, which distinguishes it from the most common forms of MODY. Currently, there is no specific therapy, and the detection of a mutation in the INS gene does not affect therapeutic tactics, however, a correct genetic diagnosis makes it possible to predict the course of diabetes and provide genetic counseling to the family

The use of Flash glucose monitoring in children with type 1 diabetes mellitus in real clinical practice

BACKGROUND: In 2018, a Frestyle Libre flash glucose monitoring system (FGM) appeared in Russia and became a potential alternative to the traditional CGM. Studies carried out to date have shown the advantages of FGM over SMBG, but only a few of them relate to real clinical practice, especially in children with type 1 diabetes.OBJECTIVE: To evaluate the efficacy of FGM in children with T1DM in relation to glycemic control indicators, the occurrence of severe hypoglycemia and diabetic ketoacidosis, as well as the satisfaction of patients and their parents with the use of FGM.MATERIALS AND METHODS: Single-center, prospective, observational cohort study. Children 4–18 years old with T1DM and HbA1c level less than 10.0% were invited to participate in the study on intensified insulin therapy (by MDI or CSII). The duration of the patient’s participation in the study was 6 months. At baseline and every 3 months thereafter, face-to-face consultations were conducted with an assessment of the general condition, HbA1c study, an assessment of glycemic indicators, progress in relation to glycemic control targets and correction of the therapy. A total of 228 patients (110 boys and 118 girls) who met the inclusion criteria were included in the study. The median age was 11.2 (8.6–14.7) years, the duration of type 1 diabetes was 3.8 (2–7.1), 136 patients received insulin therapy by CSII for 1.3 (0.8–2.6) years.RESULTS: In the general group of patients, 3 and 6 months after the start of FGM use, the HbA1c values decreased statistically significantly by 0.2%. In addition, the number of children with HbA1c <7.5% increased by 6.1 and 4.9% at 3 and 6 months, respectively, but these changes were not statistically significant. The number of cases of DKA when using FGM decreased by 74%, and the number of cases of severe hypoglycemia by 83%, thus the number of episodes decreased by 4 and 6 times, respectively. Patients and / or their parents rated the ease of use and their experience with FGM on a scale from 0 (strongly agree) to 4 (strongly disagree). The majority of children and parents positively (0 or 1) assessed the convenience of installing and wearing the sensor (72.7–98.2%) using the FGM system in general (75.0–96.4%) and in comparison with the SMBG glucometer (92.3–98.2%).CONCLUSION: The installation and use of FGM is convenient and comfortable for the vast majority of children and parents, while compared to SMBG, the use of FGM is more convenient and simpler, and glucose measurement is much faster and less painful

Detection of macro-thyrotropinaemia in patients with Hashimotos thyroiditis and subclinical hypothyroidism

The level of thyroid stimulating hormone is one of the diagnostic indicators of thyroid function. In subclinical hypothyroidism, its concentration in the blood serum increases, while the level of thyroid hormones remains normal. One of the reasons for this is the phenomenon of macrotyrotropinemia, in which the macro isoforms of thyrotropin (a complex of thyrotropic hormone with immunoglobulin) are present in the blood. It is assumed that the biological activity of macrotyrotropin is low, and may accumulate in the circulation, causing a falsely elevated level of thyroid-stimulating hormone in serum. The aim of this study is to identify the nature and prevalence of the macrothyrotropinemia phenomenon among patients with subclinical hypothyroidism in presence of autoimmune thyroiditis and a group of healthy donors. Materials and methods: Fifty serum samples of venous blood served as the material for the study: 30 patients with subclinical hypothyroidism in presence of autoimmune thyroiditis; 10, with manifesting hypothyroidism, 10 conditionally healthy donors without thyroid gland pathology (control group). The group was derived from results of the clinical laboratory at the Clinical Hospital at the Kazan station railway. Patients’ blood serum was screened for the presence of macrotrorotropin by polyethylene glycol precipitation method, followed by analysis by gel filtration chromatography. Results of this study were as follows: screening of blood sera was performed by gel filtration and affinity chromatography. Polyethylene glycol was shown to precipitate 50 to 100% serum thyrotropin, of which true macrotrothropin makes 56-98%. In the patients with subclinical hypothyroidism with a thyroid-stimulating hormone level of more than 10 pIU/ml, a trend towards an increase in the level of macrothyrotrophinaemia has been shown. The content of macrotyrotropin complex in patients with subclinical hypothyroidism, in whom the level of antibodies to thyroperoxidase is > 500 U/L, is significantly higher if compared to the patients with manifesting hypothyroidism. Elevated levels of antibodies to thyroperoxidase can lead to the generation of macrotyropin. Our findings have shown that the phenomenon of macrothyrotropinemia is quite common in patients with subclinical and manifesting hypothyroidism with Hashimoto thyroiditis (53.3%) and in control group (25%). Macrotyrotropin complex probably consists of thyrotropin and IgG. Patients with a thyroid-stimulating hormone level of > 10 pIU/ml are candidates for screening for the presence of the macrotyrotropin complex.The activity of the autoimmune process may correlate with the phenomenon of macrothyrotropinemia. The results can be used to develop an additional tool when choosing therapy in clinical practice

Изменения гемоциркуляторных и респираторных функций при бронхиальной астме у детей

One hundred and fifty bronchial asthma patients aged 6 to 14 yrs were complexly examined for haemodynamic parameters in correlation with the lung function and the diaphragm activity in different stages of the disease. The respiratory dysfunction based on the bronchial obstruction, irregular lung ventilation and reduction in the diaphragm functional activity was shown to be accompanied by changes in the regional and central blood circulation. A consistency of these disorders depended on the basic therapyУ 150 больных бронхиальной астмой в возрасте от 6 до 14 лет проведено комплексное исследование параметров гемодинамики во взаимосвязи с оценкой функции внешнего дыхания и активности диафрагмы в различные периоды заболевания. Показано, что респираторная дисфункция, в основе которой лежат бронхиальная обструкция, неравномерная вентиляция легких и снижение функциональной активности диафрагмы, сочетается с изменениями регионарной и центральной гемоциркуляции. Причем стойкость отмеченных отклонений зависит от применения базисной терапии

Approbation of a prognostic model of commodity turnover of a pharmacy organization on the example of the Sysert urban district

The purpose of the study is to test the predictive model of the turnover of a pharmacy organization on the example of the Sysert urban district.Цель исследования – апробация прогностической модели товарооборота аптечной организации на примере Сысертского городского округа

Study of marketing communications in the segment of dermatological medicines

The purpose of the study is to assess the degree of penetration of advertising into the promotion programs of individual groups of medicines.Цель исследования - оценить степень проникновения рекламы в программы продвижения отдельных групп ЛП