Использование купратных реагентов на основе хлорида меди (I) для синтеза транс-3- замещенных циклических -аминокислот

An efficient synthesis of 3-substituted cyclic amino acids via 1,4-conjugate addition of diorganocuprates to α,β-unsaturated cyclic α-aminoacids is described.The higher reactivity of copper reagents obtained from copper (I) chloride in comparison with CuCN, CuBr, CuI and CuBr*SMe2 has been shownписан эффективный способ син- теза 3-замещенных циклических аминокислот через реакцию 1,4- сопряженного присоединения купратных реагентов к a,b-ненасыщенным цикличе- ским a-аминокислотам. Показана повы- шенная активность купратных реаген- тов на основе хлорида меди (I) по срав- нению с CuCN, CuBr, CuI и CuBr*SMe2

The use of copper reagents on the base of copper (I) chloride for the synthesis of trans-3-substituted cyclic a-amino acids

An efficient synthesis of 3-substituted cyclic amino acids via 1,4-conjugate addition of diorganocuprates to α,β-unsaturated cyclic α-aminoacids is described.The higher reactivity of copper reagents obtained from copper (I) chloride in comparison with CuCN, CuBr, CuI and CuBr*SMe2 has been show

MODULATION OF ANTIBODY MEDIATED LYMPHOCYTOLYSIS IN VITRO UNDER A MAGNETIC VECTOR POTENTIAL

It is discovered that a change of a vector potential by means of a laboratory device effects on antigen-antibody reaction in lymphocytes suspension. The effect decreases lysis of lymphocytes in anti-CD3 antibodies presence and increases the destruction in anti-HLA antibodies presence. Authors propose that these effects are due to changes of antigen-antibody complexes lateral mobility and to changes of complexes  aggregates biochemical activity

Systematic synthesis of functional unsymmetric FeZn model complexes for plant purple acid phosphatases.

The heterodinuclear complexes [FeZn(L)(CH(3)CO(2))(2)](+) (L = ICIMP or IPCPMP) are structural models for the dinuclear active sites of plant purple acid phosphatases They can be systematically synthesized from mononuclear iron complexes and enhance the rate of transesterification of 2-hydroxypropyl p-nitrophenyl phosphate, an assay for the catalytic hydrolysis performed by purple acid phosphatase