974 research outputs found
Multiple class I and class II major histocompatibility complex allospecificities are generated with T cell receptor variable (V) domains created by a single Ti beta V gene family.
Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes
Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNγ producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects
P04-04. The specific phospholipid binding and neutralizing activities of the anti-HIV antibody 4E10 are separable
T cell receptor complexes containing Fc epsilon RI gamma homodimers in lieu of CD3 zeta and CD3 eta components: a novel isoform expressed on large granular lymphocytes.
Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations.
Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison.
Caracterização dos macrófagos presentes nas lesões cutâneas da hansenÃase: estudo por monoclonais
As lesões cutâneas de 16 pacientes com hansenÃase foram estudadas por imunofluorescência com anticorpos monoclonais anti-monócitos (OKM1 e anti-MO) e anti-Ia (OKIa). Foi avaliada a atividade de fosfatase ácida utilizando-se naftol AS-B1 fosfato como substrato. Os macrófagos parecem constituir uma população heterogênea em relação aos antigenos estudados neste trabalho e quanto a atividade enzimática. Em todas as formas estudadas um grande número de células eram OKIa positivas
Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function.
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