Non-hematopoietic erythropoietin-derived peptides for atheroprotection and treatment of cardiovascular diseases

Research in recent decades has shown that erythropoietin has a high cytoprotective activity, which is mainly associated with exposure to the mitochondrial link and has been confirmed in various experimental models. There is also a short-chain derivative, the 11-amino acid pyroglutamate helix B surface peptide (PHBSP), which selectively binds to the erythropoietin heterodymic receptor and reproduces its cytoprotective propertie

Результаты фармакоэпидемиологического исследования эпилепсии в Белоруссии

the lack of proper information on the epidemiological characteristics of epilepsy results in significant shortcomings in available health care. This pharmacoepidemiological study was undertaken to improve the situation. Objective: to assess the prevalence profile and management of patients with epilepsy in Minsk based on out-patient visit data obtained in health centres subordinate to the Ministry of Health of the Republic of Belarus. Materials and methods: the epidemiological study was conducted in accordance with the ILAE ‘Guidelines for epidemiologic studies on epilepsy’. Results: epilepsy incidence and prevalence were evaluated across Minsk gender- and age-based population groups. Aetiological and social aspects of epilepsy were reviewed. Out-patient visit data collected for the period from 2008 to 2012 revealed 705 patients with epilepsy. The overall epilepsy prevalence rate of the district varied from 165.2 per 100,000 population in 2008 to 275.5 per 100,000 population in 2012, while the incidence rate ranged from 36.9 per 100,000 population (in 2008) to 25.0 per 100,000 population (in 2012). The most frequently administered anti-epileptics included carbamazepine (52.9 % of patients) and valproates (31.0 % of subjects). The most commonly administered second-generation anti-epileptics were topiramate (7.1 % of patients) and lamotrigine (2.9 % of subjects). No anti-epileptics were used by 9.5 % of study subjects. Conclusions: the prevalence of epilepsy corresponds to the European Union prevalence rate. Proposals have been made concerning optimization of health care for patients with epilepsy. There is a need for large-scale pharmacoepidemiological and pharmacoeconomic studies.отсутствие должной информации об эпидемиологических характеристиках эпилепсии обусловливает существенные недостатки организации медицинской помощи. Для устранения этих факторов предпринято данное фармакоэпидемиологическое исследование. Цель: исследование профиля заболеваемости и ведения пациентов с эпилепсией в г. Минске по данным обращаемости за медицинской помощью в учреждения системы Минздрава Республики Беларусь. Материалы и методы: исследование эпидемиологии проводилось в соответствии с руководством по проведению эпидемиологических исследований эпилепсии (Guidelines for epidemiologic studies on epilepsy) ILAE. Результаты: изучена заболеваемость эпилепсией и распространенность в гендерновозрастных группах населения г. Минска. Рассмотрены этиологические и социальные аспекты эпилепсии. По данным обращаемости в амбулаторно-поликлинические учреждения за период 2008-2012 гг., выявлено 705 пациентов с эпилепсией. Общая заболеваемость эпилепсией в районе составляла от 165,2 на 100 тыс. населения в 2008 г., до 275,5 – на 100 тыс. населения в 2012 г., первичная – от 36,9 на 100 тыс. населения (в 2008 г.), до 25,0 на 100 тыс. населения (в 2012 г.). Среди назначаемых противоэпилептических препаратов наиболее часто применялись карбамазепин (52,9% пациентов) и вальпроаты (31,0% пациентов). Из противоэпилептических препаратов II поколения назначались топирамат – 7,1% пациентов, и ламотриджин – 2,9% пациентов. При этом 9,5% пациентов не принимали противоэпилептических препаратов. Выводы: распространенность эпилепсии соответствует уровню распространенности в Евросоюзе. Предложены пути оптимизации оказания противоэпилептической помощи. Существует потребность в проведении масштабных фармакоэпидемиологических и фармакоэкономических исследований

Ageism in clinical practice and improving educational programmes based on anti-ageism principles

The purpose of the article is to study the manifestations of ageism in clinical practice, the relationship of ageism with the presence of senile asthechia and comorbidity in the picture of the disease, substantiation of theimprovwment of edicational programs based on anti-age approache

EPIDEMIOLOGIC RESEARCH ON EPILEPSY IN MINSK

the lack of proper information on the epidemiological characteristics of epilepsy results in significant shortcomings in available health care. This pharmacoepidemiological study was undertaken to improve the situation. Objective: to assess the prevalence profile and management of patients with epilepsy in Minsk based on out-patient visit data obtained in health centres subordinate to the Ministry of Health of the Republic of Belarus. Materials and methods: the epidemiological study was conducted in accordance with the ILAE ‘Guidelines for epidemiologic studies on epilepsy’. Results: epilepsy incidence and prevalence were evaluated across Minsk gender- and age-based population groups. Aetiological and social aspects of epilepsy were reviewed. Out-patient visit data collected for the period from 2008 to 2012 revealed 705 patients with epilepsy. The overall epilepsy prevalence rate of the district varied from 165.2 per 100,000 population in 2008 to 275.5 per 100,000 population in 2012, while the incidence rate ranged from 36.9 per 100,000 population (in 2008) to 25.0 per 100,000 population (in 2012). The most frequently administered anti-epileptics included carbamazepine (52.9 % of patients) and valproates (31.0 % of subjects). The most commonly administered second-generation anti-epileptics were topiramate (7.1 % of patients) and lamotrigine (2.9 % of subjects). No anti-epileptics were used by 9.5 % of study subjects. Conclusions: the prevalence of epilepsy corresponds to the European Union prevalence rate. Proposals have been made concerning optimization of health care for patients with epilepsy. There is a need for large-scale pharmacoepidemiological and pharmacoeconomic studies

STUDY OF THE INCIDENCE AND PREVALENCE OF EPILEPSY IN MINSK

Abstract: epidemiological study of epilepsywas carried out in Minsk. Aim: study of the incidence and prevalence of epilepsy in the gender-age population groups in Minsk. Materials and Methods: A retrospective study was carried out by assessing the medical data of the outpatient case report forms of patients with epilepsy who were seeking medical aid during the period 2008-2012. Results: Overall incidence of epilepsy ranged from 165.2 per 100,000 population in 2008 to 275.5 per 100,000 population in 2012; incidence of primary epilepsy ranged from 36.9 per 100,000 population in 2008 to 25.0 per 100,000 population in 2012. The prevalence of epilepsy was 6.06 per 1000 population. Etiological factors that increase the risk of developing epilepsy were head injuries (28.6%), neuroinfection (13.3%), chronic alcoholism (10.0%), vascular diseases of the brain (6.7%), perinatal pathology (5 , 2%), brain tumor (2.9%). In 33.3% of patients the cause of the disease has not been established. Conclusions: the prevalence of epilepsy in Minsk is comparable with the prevalence level in the European developed countries. It seems appropriate to create a unified electronic database of patients with epilepsy and continue studies targeted on finding ways for solving medical and social problems in the Republic of Belarus