Fruitless, Doublesex And The Genetics Of Social Behavior In Drosophila Melanogaster

Two genes coding for transcription factors, fruitless and doublesex, have been suggested to play important roles in the regulation of sexually dimorphic patterns of social behavior in Drosophila melanogaster. The generalization that fruitless specified the development of the nervous system and doublesex specified non-neural tissues culminated with claims that fruitless was both necessary and sufficient to establish sex-specific patterns of behavior. Several recent articles refute this notion, however, demonstrating that at a minimum, both fruitless and doublesex are involved in establishing sexually dimorphic features of neural circuitry and behavior in fruit flies

Transforming U.S. Particle Physics Education: A Snowmass 2021 Study

The pursuit of knowledge in particle physics requires constant learning. As new tools become available, new theories are developed, and physicists search for new answers with ever-evolving methods. However, it is the case that formal educational systems serve as the primary training grounds for particle physicists. Graduate school (and undergraduate school to a lesser extent) is where researchers learn most of the technical skills required for research, develop scientific problem-solving abilities, learn how to establish themselves in their field, and begin developing their career. It is unfortunate, then, that the skills gained by physicists during their formal education are often mismatched with the skills actually required for a successful career in physics. We performed a survey of the U.S. particle physics community to determine the missing elements of graduate and undergraduate education and to gauge how to bridge these gaps. In this contributed paper, part of the 2021-22 Snowmass Community Planning Exercise, we report the results of this survey. We also recommend several specific community actions to improve the quality of particle physics education; the "community" here refers to physics departments, national labs, professional societies, funding agencies, and individual physicists.Comment: contribution to Snowmass 202

Simulation and observations of stratospheric aerosols from the 2009 Sarychev volcanic eruption

We used a general circulation model of Earth’s climate to conduct simulations of the 12-16 June 2009 eruption of Sarychev volcano (48.1°N, 153.2°E). The model simulates the formation and transport of the stratospheric sulfate aerosol cloud from the eruption and the resulting climate response. We compared optical depth results from these simulations with limb scatter measurements from the Optical Spectrograph and InfraRed Imaging System (OSIRIS), in situ measurements from balloon-borne instruments lofted from Laramie, Wyoming (41.3°N, 105.7°W), and five lidar stations located throughout the Northern Hemisphere. The aerosol cloud covered most of the Northern Hemisphere, extending slightly into the tropics, with peak backscatter measured between 12 and 16 km in altitude. Aerosol concentrations returned to near background levels by Spring, 2010. After accounting for expected sources of discrepancy between each of the data sources, the magnitudes and spatial distributions of aerosol optical depth due to the eruption largely agree. In conducting the simulations, we likely overestimated both particle size and the amount of SO2 injected into the stratosphere, resulting in modeled optical depth values that were a factor of 2-4 too high. Model results of optical depth due to the eruption show a peak too late in high latitudes and too early in low latitudes, suggesting a problem with stratospheric circulation in the model. The model also shows a higher annual decay rate in optical depth than is observed, showing an inaccuracy in seasonal deposition rates. The modeled deposition rate of sulfate aerosols from the Sarychev eruption is higher than the rate calculated for aerosols from the 1991 eruption of Mt. Pinatubo

The Validity of Peer Review in a General Medicine Journal

All the opinions in this article are those of the authors and should not be construed to reflect, in any way, those of the Department of Veterans Affairs

Increasing water cycle extremes in California and in relation to ENSO cycle under global warming

Since the winter of 2013–2014, California has experienced its most severe drought in recorded history, causing statewide water stress, severe economic loss and an extraordinary increase in wildfires. Identifying the effects of global warming on regional water cycle extremes, such as the ongoing drought in California, remains a challenge. Here we analyse large-ensemble and multi-model simulations that project the future of water cycle extremes in California as well as to understand those associations that pertain to changing climate oscillations under global warming. Both intense drought and excessive flooding are projected to increase by at least 50% towards the end of the twenty-first century; this projected increase in water cycle extremes is associated with a strengthened relation to El Niño and the Southern Oscillation (ENSO)—in particular, extreme El Niño and La Niña events that modulate California’s climate not only through its warm and cold phases but also its precursor patterns

Observation of activity prior to dielectric breakdown in liquid xenon with the XeBrA experiment

Maintaining the electric fields necessary for the current generation of noble liquid time projection chambers (TPCs), with drift lengths exceeding one meter, requires a large negative voltage applied to their cathode. Delivering such high voltage is associated with an elevated risk of electrostatic discharge and electroluminescence, which would be detrimental to the performance of the TPC. The Xenon Breakdown Apparatus (XeBrA) is a five-liter high-voltage test chamber built to investigate the factors contributing to high voltage breakdown in noble liquids. Area scaling and surface finish were observed to be the dominant factors affecting breakdown. In addition, small electrical activity was frequently observed during high voltage ramps prior to electrostatic discharge. The position of breakdowns was reconstructed with a system of high-speed cameras and good agreement with electric field simulations was found. Based on the results presented in this work, we recommend that the next generation of TPCs should not withstand fields larger than 20 kV/cm on the electrode surfaces.Comment: 29 pages, 13 figures; typo in the author list correcte

Phase field approach to optimal packing problems and related Cheeger clusters

In a fixed domain of $\Bbb{R}^N$ we study the asymptotic behaviour of optimal clusters associated to $\alpha$-Cheeger constants and natural energies like the sum or maximum: we prove that, as the parameter $\alpha$ converges to the "critical" value $\Big (\frac{N-1}{N}\Big ) _+$, optimal Cheeger clusters converge to solutions of different packing problems for balls, depending on the energy under consideration. As well, we propose an efficient phase field approach based on a multiphase Gamma convergence result of Modica-Mortola type, in order to compute $\alpha$-Cheeger constants, optimal clusters and, as a consequence of the asymptotic result, optimal packings. Numerical experiments are carried over in two and three space dimensions