Science Concierge: A fast content-based recommendation system for scientific publications

Finding relevant publications is important for scientists who have to cope with exponentially increasing numbers of scholarly material. Algorithms can help with this task as they help for music, movie, and product recommendations. However, we know little about the performance of these algorithms with scholarly material. Here, we develop an algorithm, and an accompanying Python library, that implements a recommendation system based on the content of articles. Design principles are to adapt to new content, provide near-real time suggestions, and be open source. We tested the library on 15K posters from the Society of Neuroscience Conference 2015. Human curated topics are used to cross validate parameters in the algorithm and produce a similarity metric that maximally correlates with human judgments. We show that our algorithm significantly outperformed suggestions based on keywords. The work presented here promises to make the exploration of scholarly material faster and more accurate.Comment: 12 pages, 5 figure

Coupled Ito equations of continuous quantum state measurement, and estimation

We discuss a non-linear stochastic master equation that governs the time-evolution of the estimated quantum state. Its differential evolution corresponds to the infinitesimal updates that depend on the time-continuous measurement of the true quantum state. The new stochastic master equation couples to the two standard stochastic differential equations of time-continuous quantum measurement. For the first time, we can prove that the calculated estimate almost always converges to the true state, also at low-efficiency measurements. We show that our single-state theory can be adapted to weak continuous ensemble measurements as well.Comment: 5 pages, RevTeX4. In version v2 some minor revisions and clarifications have been incorporated. Moreover, a new reference has been included. Accepted for publication in Journal of Physics A: Mathematical and Genera

Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets

The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals. In recent years, the relevance of changes in peripheral lymphocytes in age-associated neurologic diseases has become more evident. Due to the lack of immunological studies, covering more than one event after mitogenic activation, we envisaged a new concept in the present study, aiming to investigate several events, starting from T cell receptor (TCR) ligation up to T cell proliferation. In addition, we addressed the question whether changes are present in the subsets (CD4, CD8) with aging. Phosphorylation of tyrosine residues declines with increasing age in CD4+ cells. Fewer levels of CD69 positive cells after 4 h mitogenic activation, altered expression of cytokines (IL2, IFN-gamma and TNF-alpha; 22 h) and lower proliferation (72 h) were determined in aging. Moreover, it could be shown that CD8+ lymphocytes react more effectively to mitogenic stimulation with reference to CD69 expression and proliferation in both age groups (60 years old). These data indicate that T cell activation, mediated by TCR engagement, is significantly impaired in aging and both subsets are affected. However, bypassing the TCR does not fully restore T cell function, indicating that there are more mechanisms involved than impaired signal transduction through TCR only. The results will be discussed in relation to their relevance in neurodegenerative and psychiatric disorders

A quantitative image evaluation study of a concurrent photon amplification treated emulsion

A study was performed to evaluate the effect of concurrent photon amplification (CPA) on Kodak Tri-X Pan emulsion in regard to image quality. The study evaluated detective quantum efficiency (DQE), modulation transfer function (MTF), and information content (IC) as a function of exposure in a comparison between normal exposure and CPA. The results showed CPA to enhance image quality relative to normal exposure at very low exposure levels. As the exposure was increased, normally exposed images became comparable and then exceeded CPA exposures in image quality. The exposure level at which normal exposure became preferential was distinct with each image quality measure

Conduction Channels of One-Atom Zinc Contacts

We have determined the transmission coefficients of atomic-sized Zn contacts using a new type of breakjunction which contains a whisker as a central bridge. We find that in the last conductance plateau the transport is unexpectedly dominated by a well-transmitting single conduction channel. We explain the experimental findings with the help of a tight-binding model which shows that in an one-atom Zn contact the current proceeds through the 4s and 4p orbitals of the central atom.Comment: revtex4, 5 pages, 5 figure

Memory, Synapse Stability, and β-Adducin

In this issue of Neuron, two studies by Pielage et al. and Bednarek and Caroni suggest that the cytoskeleton regulator β-Adducin provides an activity-dependent switch controlling synapse disassembly and assembly at the Drosophila neuromuscular junction (NMJ) and the mouse hippocampus. In mice, the β-Adducin switch is required for the improvement of learning and memory induced by enriched environments

Linking the metabolic rate of individuals to species ecology and life history in key Arctic copepods

This study compares the active and resting metabolic rates of species and life stages of copepods during the Arctic winter. Measurements were taken on individuals, and rates were described as functions of body mass. Differences in metabolic rate between species and life stages with the same mass were taken as evidence of distinct lifestyles. Copepod species that opportunistically feed during winter had higher active metabolic rates than species in a dormant state, but their resting metabolic rates were similar. Furthermore, metabolic rate increased more rapidly with mass for males compared to females and juvenile copepods with the result that the largest males had much greater rates. Whether the copepod was active or at rest had the greatest effect on metabolic rate, followed by body mass, species, and life stage having the least effect. Individual measurements on copepods can facilitate comparisons of metabolic rate across mass and further enable the measurement of rates when the individuals are active or at rest. The plasticity in metabolic rate found in the present study enables winter active species to have as low metabolic rates as dormant species and then suddenly mobilize and increase metabolism, likely as an adaptation to the scarce and random food availability during winter