Decreased susceptibility to ciprofloxacin in Salmonella enterica serotype typhi, United Kingdom.

In 1999, 23% of Salmonella enterica serotype Typhi isolates from patients in the United Kingdom exhibited decreased susceptibility to ciprofloxacin (MIC 0.25-1.0 mg/L); more than half were also resistant to chloramphenicol, ampicillin, and trimethoprim. Increasing numbers of treatment failures have been noted. Most infections have been in patients with a recent history of travel to India and Pakistan

Nonlinear wave propagation and reconnection at magnetic X-points in the Hall MHD regime

The highly dynamical, complex nature of the solar atmosphere naturally implies the presence of waves in a topologically varied magnetic environment. Here, the interaction of waves with topological features such as null points is inevitable and potentially important for energetics. The low resistivity of the solar coronal plasma implies that non-MHD effects should be considered in studies of magnetic energy release in this environment. This paper investigates the role of the Hall term in the propagation and dissipation of waves, their interaction with 2D magnetic X-points and the nature of the resulting reconnection. A Lagrangian remap shock-capturing code (Lare2d) is used to study the evolution of an initial fast magnetoacoustic wave annulus for a range of values of the ion skin depth in resistive Hall MHD. A magnetic null-point finding algorithm is also used to locate and track the evolution of the multiple null-points that are formed in the system. Depending on the ratio of ion skin depth to system size, our model demonstrates that Hall effects can play a key role in the wave-null interaction. In particular, the initial fast-wave pulse now consists of whistler and ion-cyclotron components; the dispersive nature of the whistler wave leads to (i) earlier interaction with the null, (ii) the creation of multiple additional, transient nulls and, hence, an increased number of energy release sites. In the Hall regime, the relevant timescales (such as the onset of reconnection and the period of the oscillatory relaxation) of the system are reduced significantly, and the reconnection rate is enhanced.Comment: 13 pages, 10 figure

Salmonella typhimurium phage types linked with pigs and their association with human infection in England and Wales

The most common Salmonella isolated from pigs in the United Kingdom is Salmonella enterica serovar Typhimurium. Phage typing continues to be a useful method for strain differentiation of this serovar and the predominant phage types in pigs, include definitive phage types (DT) 104, 104b, 193 and provisional phage type (PT) U302. In 2002 the Laboratory of Enteric Pathogens (LEP) reported on 1221 human cases infected with strains of these phage types. Although some of the infections were linked to pig products the majority were due to other sources

The fractional integrated bi- parameter smooth transition autoregressive model

This paper introduces the fractionally integrated Bi-parameter smooth transition autoregressive model (FI-BSTAR model) as an extension of BSTAR model proposed by Siliverstovs (2005) and the fractionally integrated STAR model (FI-STAR model) proposed by van Dijk et al. (2002). Our FI-BSTAR model is able to simultaneously describe persistence and asymmetric smooth structural change in time series. An empirical application using monthly growth rates of the American producer price index is provided.Long Memory, Nonlinearity, Asymmetry, STAR models.

Particle dynamics in a non-flaring solar active region model

The aim of this work is to investigate and characterise particle behaviour in a (observationally-driven) 3D MHD model of the solar atmosphere above a slowly evolving, non-flaring active region. We use a relativistic guiding-centre particle code to investigate particle acceleration in a single snapshot of the 3D MHD simulation. Despite the lack of flare-like behaviour in the active region, direct acceleration of electrons and protons to non-thermal energies (≲ 42 MeV) was found, yielding spectra with high-energy tails which conform to a power law. Examples of particle dynamics, including particle trapping caused by local electric rather than magnetic field effects, are observed and discussed, together with implications for future experiments which simulate non-flaring active region heating and reconnection.Publisher PDFPeer reviewe

Genetic relationships among strains of Salmonella enteritidis in a national epidemic in Switzerland

A collection of Salmonella enteritidis strains isolated in Switzerland (1965-90) was characterized. The phage type and plasmid profile of isolates were compared with the copy number and insertion loci of the DNA insertion element IS200. Three clonal lines of S. enteritidis were identified by IS200 profile; the various phage types were subtypes reproducibly associated with one of these lines. All human and poultry isolates contained a 38 Mda plasmid which hybridized with a mouse virulence-associated gene probe. In S. enteritidis, the IS200 profile is a race-specific molecular marker of the chromosome, and may be particularly applicable for studying the epidemiology of less common serovar

Is magnetic topology important for heating the solar atmosphere?

CEP and JT acknowledge the support of STFC through the St Andrew’s SMTG consolidated grant. JEHS is supported by STFC as a PhD student. SJE is supported STFC through the Durham University Impact Acceleration Account.Magnetic fields permeate the entire solar atmosphere weaving an extremely complex pattern on both local and global scales. In order to understand the nature of this tangled web of magnetic fields, its magnetic skeleton, which forms the boundaries between topologically distinct flux domains, may be determined. The magnetic skeleton consists of null points, separatrix surfaces, spines and separators. The skeleton is often used to clearly visualize key elements of the magnetic configuration, but parts of the skeleton are also locations where currents and waves may collect and dissipate. In this review, the nature of the magnetic skeleton on both global and local scales, over solar cycle time scales, is explained. The behaviour of wave pulses in the vicinity of both nulls and separators is discussed and so too is the formation of current layers and reconnection at the same features. Each of these processes leads to heating of the solar atmosphere, but collectively do they provide enough heat, spread over a wide enough area, to explain the energy losses throughout the solar atmosphere? Here, we consider this question for the three different solar regions: Active regions, open-field regions and the quiet Sun. We find that the heating of active regions and open-field regions is highly unlikely to be due to reconnection or wave dissipation at topological features, but it is possible that these may play a role in the heating of the quiet Sun. In active regions, the absence of a complex topology may play an important role in allowing large energies to build up and then, subsequently, be explosively released in the form of a solar flare. Additionally, knowledge of the intricate boundaries of open-field regions (which the magnetic skeleton provides) could be very important in determining the main acceleration mechanism(s) of the solar wind.PostprintPeer reviewe

The Emergence of a new Salmonella Typhimurium phage type associated with pigs

A new phage type of Salmonella enterica serovar Typhimurium has been identified that appears to have a strong epidemiological link with pigs and pig products used for human consumption. In 1997 a strain emerged that was resistant to all the S. Typhimurium typing phages; this resulted in a new phage being adapted to type this strain. The type defined by this phage has been given the provisional type designation U310 and the majority of isolates are resistant to tetracyclines R-type T)