The Serendipitous Discovery of a Group or Cluster of young Galaxies at z=2.40 in Deep Hubble Space Telescope WFPC2 Images

We report the serendipitous discovery of a group or cluster of young galaxies at $z\simeq$2.40 in a 24-orbit HST/WFPC2 exposure of the field around the weak radio galaxy 53W002. Potential cluster members were identified on ground-based narrow-band redshifted Ly$\alpha$ images and confirmed via spectroscopy. In addition to the known weak radio galaxy 53W002 at z=2.390, two other objects were found to have excess narrow-band Ly$\alpha$ emission at $z\simeq$2.40. Both have been spectroscopically confirmed, and one clearly contains a weak AGN. They are located within one arcminute of 53W002, or $\sim0.23h_{100}^{-1}$Mpc ($q_o$=0.5) at $z\simeq$2.40, which is the physical scale of a group or small cluster of galaxies. Profile fitting of the WFPC2 images shows that the objects are very compact, with scale lengths $\simeq$0\farcs 1 ($\simeq0.39h_{100}^{-1}$kpc), and are rather faint (luminosities < L*), implying that they may be sub-galactic sized objects. We discuss these results in the context of galaxy and cluster evolution and the role that weak AGN may play in the formation of young galaxies.Comment: Accepted for publication in The Astrophysical Journal (Letters). 13 pages of gzip compressed and uuencoded PS. Figures are available at http://www.phys.unsw.edu.au/~spd/bib.htm

The Top Ten List of Gravitational Lens Candidates from the HST Medium Deep Survey

A total of 10 good candidates for gravitational lensing have been discovered in the WFPC2 images from the HST Medium Deep Survey (MDS) and archival primary observations. These candidate lenses are unique HST discoveries, i.e. they are faint systems with sub-arcsecond separations between the lensing objects and the lensed source images. Most of them are difficult objects for ground-based spectroscopic confirmation or for measurement of the lens and source redshifts. Seven are ``strong lens'' candidates which appear to have multiple images of the source. Three are cases where the single image of the source galaxy has been significantly distorted into an arc. The first two quadruply lensed candidates were reported in Ratnatunga et al 1995 (ApJL, 453, L5) We report on the subsequent eight candidates and describe them with simple models based on the assumption of singular isothermal potentials. Residuals from the simple models for some of the candidates indicate that a more complex model for the potential will probably be required to explain the full structural detail of the observations once they are confirmed to be lenses. We also discuss the effective survey area which was searched for these candidate lens objects.Comment: 26 pages including 12 figures and 10 tables. AJ Vol. 117, No.

The technology potentials for satellite spacing and frequency sharing

Satellite spacing and frequency sharing in microwave relay system

New "Einstein Cross" Gravitational Lens Candidates in HST WFPC2 Survey Images

We report the serendipitous discovery of ``Einstein cross'' gravitational lens candidates using the Hubble Space Telescope. We have so far discovered two good examples of such lenses, each in the form of four faint blue images located in a symmetric configuration around a red elliptical galaxy. The high resolution of HST has facilitated the discovery of this optically selected sample of faint lenses with small (~1 arcsec) separations between the (I ~ 25-27) lensed components and the much brighter (I ~ 19-22) lensing galaxies. The sample has been discovered in the routine processing of HST fields through the Medium Deep Survey pipeline, which fits simple galaxy models to broad band filter images of all objects detected in random survey fields using WFPC2. We show that the lens configuration can be modeled using the gravitational field potential of a singular isothermal ellipsoidal mass distribution. With this model the lensing potential is very similar, both in ellipticity and orientation, to the observed light distribution of the elliptical galaxy, as would occur when stars are a tracer population. The model parameters and associated errors have been derived by 2-dimensional analysis of the observed images. The maximum likelihood procedure iteratively converges simultaneously on the model for the lensing elliptical galaxy and the source of the lensed components. A systematic search is in progress for other gravitational lens candidates in the HST Medium Deep Survey. This should eventually lead to a good statistical estimate for lensing probabilities, and enable us to probe the cosmological component of the observed faint blue galaxy population.Comment: Accepted for Astrophysical Journal Letters, 1995 November 1 LaTex, 10 pages, includes 2 figures 1 table, tarred gzip uuencoded using uufiles scrip

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including resurgence of AR and AR splice variant (ARV) signaling. Emerging evidence suggests that Sigma1 (also known as sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein homeostasis. We reported previously that some Sigma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways. We hypothesized that these Sigma1-mediated responses could be exploited to suppress AR protein levels and activity. Here we demonstrate that treatment with a small-molecule Sigma1 inhibitor prevented 5α- dihydrotestosterone-mediated nuclear translocation of AR and induced proteasomal degradation of AR and ARV, suppressing the transcriptional activity and protein levels of both full-length and splice-variant AR. Consistent with these data, RNAi knockdown of Sigma1 resulted in decreased AR levels and transcriptional activity. Furthermore, Sigma1 physically associated with ARV7 and A

Canine Morphology: Hunting for Genes and Tracking Mutations

In this essay, Abigail Shearin and Elaine Ostrander discuss the proposed genomic mechanisms for the extraordinary level of phenotypic variation observed in the domestic dog and the evidence detailing the variants responsible for the many shapes, sizes, textures, and colors of man's best friend

The morphological mix of field galaxies to I=24.25 magnitudes (b=26 magnitudes) from a deep Hubble Space Telescope WFPC2 image

We determine the morphological mix of field galaxies down to $m_{I}\simeq 24.25$ mag ($m_{B}\sim 26.0$ mag) from a single ultradeep HST WFPC2 image in both the $V_{606}$ and $I_{814}$ filters. In total, we find 227 objects with $m_{I}\le 24.5$ mag and classify these into three types: ellipticals (16%), early-type spirals (37%) and late-type spirals/Irregulars (47%). The differential number counts for each type are compared to simple models in a standard flat cosmology. We find that both the elliptical and early-type spiral number counts are well described by {\it little or no}-evolution models, but only when normalized at $b_{J} = 18.0$ mag. Given the uncertainties in the luminosity function (LF) normalization, both populations are consistent with a mild evolutionary scenario based on a normal/low rate of star-formation. This constrains the end of the last {\it major} star-formation epoch in the giant galaxy populations to $z\geq 0.8$. Conversely, the density of the observed late-type/Irregular population is found to be a factor of 10 in excess of the conventional no-evolution model. This large population might be explained by either a modified {\it local} dwarf-rich LF, and/or strong evolution acting on the {\it local} LF. For the dwarf-rich case, a {\it steep} faint-end Schechter-slope ($\alpha\simeq -1.8$) is required plus a five-fold increase in the dwarf normalization. For a purely evolving model based on a {\it flat} Loveday {\it et al.} (1992) LF ($\alpha\simeq -1.0$), a ubiquitous starburst of $\Delta I\sim$2.0 mag is needed at z$\simeq 0.5$ for the {\it entire} late-type population. We argue for a combination of these possibilities, and show that for a steep Marzke {\it et al.} (1994) LF ($\alpha\simeq -1.5$), a starburst of $\sim$ 1.3 mag is requiredComment: 9 pages, 3 figures (2 colour). The figures are available at http://www.phys.unsw.edu.au/~spd/bib.htm

Fine mapping a locus controlling leg morphology in the domestic dog

The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms