Role of unphysical solution in nucleon QCD sum rules

We show that at certain values of QCD condensates the nucleon QCD sum rules with "pole+continuum" model for the hadron spectrum obtain an unphysical solution. This provides constrains for the values of condensates to be consistent with existence of a physical solutions. The constrains become much weaker if the radiative corrections are included perturbatively. We demonstrate that the most important dependence of nucleon mass on the quark scalar condensate becomes much weaker under factorization assumption for the four-quark and six-quark condensates.Comment: 13 pages, 6 figure

Investigation of Zero-Sound Dispersion Equation in the Complex Plane of Frequency

The known solutions to the zero-sound dispersion equation are considered as placed on the physical and unphysical sheets in the complex plane of frequency.Comment: 15 pages, 7 figure

Analysis of the effectiveness of stenting the duct of the pancreas in patients with impacted stones of the major duodenal papilla

Purpose: to evaluate the impact of stenting of the pancreatic duct on the course of biliary pancreatitis for patients with impacted stone of major duodenal papilla.Materials and methods: A retrospective analysis of the treatment of 90 patients with impacted stone of major duodenal papilla that underwent endoscopic interventions on the major duodenal papilla in 1/3 of cases accompanied by the installation of a stent of the pancreatic duct. Depending on the stenting, the patients were divided into two groups - the first group (n = 31 patients) with the stented pancreatic duct, the second group (n = 59 patients) - without stent placement. The groups were compared by the dynamics of changes and the normalization time of laboratory indicators, sonographic signs of biliary and pancreatic hypertension before and after the intervention.Results: Following differences were observed: in the group of stented patients the hyperamylasemia has reduced with the period of normalization of amylase 1.5 times less (p = 0.005) , decrease of amylase at the stented patients with signs of pancreaticectasia at ERCP by 55.6% comparing to the patients without stent - 7.1% (p = 0.005). Laboratory signs of development of post-ERCP pancreatitis were noted in 6.5% of stented and 11.9% of non-stented patients. The average hospitalization time in the first group was 11.5 ± 4.1 days and in the second - 15.5 ± 9.6 days (p = 0.032).Conclusion: Stenting the pancreatic duct in patients with impacted stone of major duodenal papilla reduces the risk of postmanipulation pancreatitis, speeds up the normalization of laboratory markers of acute biliary pancreatitis, reduces the time of hospitalization of this category of patients, has not only a preventive but also therapeutic effect

Foeto-foetal transfusion syndrome in dichorionic diamniotic twins: a clinical case

Background. Management of multiple gestation complicated by the foeto-foetal transfusion syndrome is among most intricate modern obstetric issues. The syndrome develops in 10–20% of monochorionic diamniotic twins leading to 80–100% mortality in one or both twins if left uncorrected, especially in early syndrome cases. Although foeto-foetal transfusion usually develops with monochorionic placentae, there are notable exceptions of vascular placental anastomoses reported with dichorionic monozygotic twins. The disease supposedly entails from an imbalanced blood interflow between dichorionic twins due to placental vascular anastomoses.Clinical Case Description. Patient S., 32 yo, visited perinatal diagnostics at the Territorial Perinatal Centre of the Children’s Territorial Clinical Hospital with a preliminary diagnosis: 22 weeks and 5 days’ pregnancy. Dichorionic diamniotic twins. Threat of extremely preterm birth. Two caesarean uterine scars. Gestational diabetes mellitus.Medical files: patient history, pregnancy calendar. Pregnancy was regularly monitored with main ultrasound foetometry, foeto-foetal transfusion dynamics control and Doppler velocimetry.Ultrasonographic signs of abnormal haemodynamics underlying the foeto-foetal transfusion syndrome were detected at the first scan at 11–13 weeks 6 days’ term as collar space thickening in one foetus. Hydramnios in one foetus and oligohydramnios in the other were diagnosed at 28 weeks’ gestation conclusively indicating the foeto-foetal transfusion syndrome. This evidence suggested the formation of placental anastomoses, which was confirmed morphologically in placenta examination.Conclusion. A timely diagnosis and correction of emerging complications allowed prolongation of pregnancy in hospital conditions to 33–34 weeks. Both boys were live-born with Apgar score 7–8

A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40

BACKGROUND: Mantle cell lymphoma (MCL) is a distinct clinical pathologic subtype of B cell non-Hodgkin’s lymphoma often associated with poor prognosis. New therapeutic approaches based on boosting anti-tumor immunity are needed. MCL is associated with overexpression of cyclin D1 thus rendering this molecule an interesting target for immunotherapy. METHODS: We show here a novel strategy for the development of recombinant vaccines carrying cyclin D1 cancer antigens that can be targeted to dendritic cells (DCs) via CD40. RESULTS: Healthy individuals and MCL patients have a broad repertoire of cyclin D1-specific CD4(+) and CD8(+) T cells. Cyclin D1-specific T cells secrete IFN-γ. DCs loaded with whole tumor cells or with selected peptides can elicit cyclin D1-specific CD8(+) T cells that kill MCL tumor cells. We developed a recombinant vaccine based on targeting cyclin D1 antigen to human DCs via an anti-CD40 mAb. Targeting monocyte-derived human DCs in vitro with anti-CD40-cyclin D1 fusion protein expanded a broad repertoire of cyclin D1-specific CD4(+) and CD8(+) T cells. CONCLUSIONS: This study demonstrated that cyclin D1 represents a good target for immunotherapy and targeting cyclin D1 to DCs provides a new strategy for mantle cell lymphoma vaccine. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-015-0131-7) contains supplementary material, which is available to authorized users

Psychology - Pedagogical Bases of Key Transprofessional Competences Development in the Professional Reorientation

The topicality of the problem stated in article is caused by the fact that now the process of interaction of a person and his profession becomes more complicated and it demands the formation of such competences which will allow him quickly and freely to guide in the modern labor market, to change the course of professional activity as well as maintenance and quality of his work during all life. The purpose of this article is to study the psychological readiness to develop new kinds of activity of teachers at vocational school in the conditions of a professional reorientation and also to design the process of psychology-pedagogical assistance to develop new kinds of activity of adult teachers at vocational school in the conditions of professional reorientation. The methodological basis of the research was made by conceptual provisions of personal-focused approach in education and also the questions of adults continuous professional education organization. In the course of the research such theoretical scientific methods as analysis, synthesis, concretizing, generalization were applied. Materials on carrying out and the results of pilot study of psychological readiness to develop new kinds of teachers activity at vocational school in the conditions of professional reorientation are of practical value for the psychologists, educational psychologists of the education system, teachers of vocational school working on a problem of psychology -pedagogical assistance to development of new kinds of activity of adult teachers in the system of secondary professional education. (C) 2019 Published by Future Academy www.FutureAcademy.org.U

Self-efficacy as a personality predictor of the career orientations of college students

In the context of the modern dynamic socio-economic environment, career-related issues are becoming relevant to psychological and pedagogical sciences as it is professional development that enables people to realize their abilities, capabilities, and needs. Career orientation should be identified as early as possible in order to obtain significant achievements. An important issue is related to career orientation predictors, which determine future achievements and career choice. The study discusses conceptual provisions and methodological approaches to assessing the career orientations of college students with different levels of self-efficacy. The purpose of the research is to study theoretical and methodological approaches and aspects of the psychological assessment of self-efficacy as a personality predictor of the career orientations of college students. The study was conducted with the participation of a representative sample of 558 third-year students aged 18 to 20 on the campus of the Ural State College named after I. Polzunov (Ekaterinburg) (average age is 18.7 years). he practical significance of the study arises from the possibility to use the results obtained in order to implement programs aimed at improving self-efficacy in adolescents. The research is of practical value for organizational psychologists, educational psychologists, and teachers. © 2021 Eskisehir Osmangazi University. All rights reserved