Targeting kidney mesangium by nanoparticles of defined size

Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of targeting ligands) of nanoparticles enable their ability to overcome biological barriers and reach designated cellular destinations in sufficient amounts to elicit biological efficacy are of interest. Despite proven success in nanoparticle accumulation at cellular locations and occurrence of downstream therapeutic effects (e.g., target gene inhibition) in a selected few organs such as tumor and liver, reports on effective delivery of engineered nanoparticles to other organs still remain scarce. Here, we show that nanoparticles of ~75 ± 25-nm diameters target the mesangium of the kidney. These data show the effects of particle diameter on targeting the mesangium of the kidney. Because many diseases originate from this area of the kidney, our findings establish design criteria for constructing nanoparticle-based therapeutics for targeting diseases that involve the mesangium of the kidney

Dynamical solution to the μ\mu problem at TeV scale

We introduce a new confining force (\mu-color) at TeV scale to dynamically generate a supersymmetry preserving mass scale which would replace the \mu parameter in the minimal supersymmetric standard model (MSSM). We discuss the Higgs phenomenology and also the pattern of soft supersymmetry breaking parameters allowing the correct electroweak symmetry breaking within the \mu-color model, which have quite distinctive features from the MSSM and also from other generalizations of the MSSM.Comment: 12 pages, REVte

Dynamic model of fiber bundles

A realistic continuous-time dynamics for fiber bundles is introduced and studied both analytically and numerically. The equation of motion reproduces known stationary-state results in the deterministic limit while the system under non-vanishing stress always breaks down in the presence of noise. Revealed in particular is the characteristic time evolution that the system tends to resist the stress for considerable time, followed by sudden complete rupture. The critical stress beyond which the complete rupture emerges is also obtained

Putative spin liquid in the triangle-based iridate Ba3_3IrTi2_2O9_9

We report on thermodynamic, magnetization, and muon spin relaxation measurements of the strong spin-orbit coupled iridate Ba$_3$IrTi$_2$O$_9$, which constitutes a new frustration motif made up a mixture of edge- and corner-sharing triangles. In spite of strong antiferromagnetic exchange interaction of the order of 100~K, we find no hint for long-range magnetic order down to 23 mK. The magnetic specific heat data unveil the $T$-linear and -squared dependences at low temperatures below 1~K. At the respective temperatures, the zero-field muon spin relaxation features a persistent spin dynamics, indicative of unconventional low-energy excitations. A comparison to the $4d$ isostructural compound Ba$_3$RuTi$_2$O$_9$ suggests that a concerted interplay of compass-like magnetic interactions and frustrated geometry promotes a dynamically fluctuating state in a triangle-based iridate.Comment: Physical Review B accepte

Dynamic model for failures in biological systems

A dynamic model for failures in biological organisms is proposed and studied both analytically and numerically. Each cell in the organism becomes dead under sufficiently strong stress, and is then allowed to be healed with some probability. It is found that unlike the case of no healing, the organism in general does not completely break down even in the presence of noise. Revealed is the characteristic time evolution that the system tends to resist the stress longer than the system without healing, followed by sudden breakdown with some fraction of cells surviving. When the noise is weak, the critical stress beyond which the system breaks down increases rapidly as the healing parameter is raised from zero, indicative of the importance of healing in biological systems.Comment: To appear in Europhys. Let

Infrared Hall conductivity of Na0.7_{0.7}CoO2_2

We report infrared Hall conductivity $\sigma_{xy}(\omega)$ of Na$_{0.7}$CoO$_2$ thin films determined from Faraday rotation angle $\theta_{F}$ measurements. $\sigma_{xy}(\omega)$ exhibits two types of hole conduction, Drude and incoherent carriers. The coherent Drude carrier shows a large renormalized mass and Fermi liquid-like behavior of Hall scattering rate, $\gamma_{H} \sim aT^{2}$. The spectral weight is suppressed and disappears at T = 120K. The incoherent carrier response is centered at mid-IR frequency and shifts to lower energy with increasing T. Infrared Hall constant is positive and almost independent of temperature in sharp contrast with the dc-Hall constant.Comment: 5 Pages, 5 Figures. Author list corrected in metadata only, paper is unchange

Magneto-electric effect in NdCrTiO5

We have measured the dielectric constant and the pyroelectric current of orthorhombic (space group $Pbam$) NdCrTiO$_5$ polycrystalline samples. The dielectric constant and the pyroelectric current show features associated with ferroelectric transitions at the antiferromagnetic transition temperature ($T_{\text{N}}$ = 21 K). The effect of magnetic fields is to enhance the features almost linearly up to the maximum measured field (7 T) with a spontaneous polarization value of $\sim 3.5 \mu$C/m$^2$. Two possible scenarios, the linear magnetoelectric effect and multiferroicity (antiferromagnetism + ferroelectricity), are discussed as possible explanations for the observations.Comment: 7 pages, 6 figure