54,876 research outputs found
Targeting kidney mesangium by nanoparticles of defined size
Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of targeting ligands) of nanoparticles enable their ability to overcome biological barriers and reach designated cellular destinations in sufficient amounts to elicit biological efficacy are of interest. Despite proven success in nanoparticle accumulation at cellular locations and occurrence of downstream therapeutic effects (e.g., target gene inhibition) in a selected few organs such as tumor and liver, reports on effective delivery of engineered nanoparticles to other organs still remain scarce. Here, we show that nanoparticles of ~75 ± 25-nm diameters target the mesangium of the kidney. These data show the effects of particle diameter on targeting the mesangium of the kidney. Because many diseases originate from this area of the kidney, our findings establish design criteria for constructing nanoparticle-based therapeutics for targeting diseases that involve the mesangium of the kidney
Dynamical solution to the problem at TeV scale
We introduce a new confining force (\mu-color) at TeV scale to dynamically
generate a supersymmetry preserving mass scale which would replace the \mu
parameter in the minimal supersymmetric standard model (MSSM). We discuss the
Higgs phenomenology and also the pattern of soft supersymmetry breaking
parameters allowing the correct electroweak symmetry breaking within the
\mu-color model, which have quite distinctive features from the MSSM and also
from other generalizations of the MSSM.Comment: 12 pages, REVte
Dynamic model of fiber bundles
A realistic continuous-time dynamics for fiber bundles is introduced and
studied both analytically and numerically. The equation of motion reproduces
known stationary-state results in the deterministic limit while the system
under non-vanishing stress always breaks down in the presence of noise.
Revealed in particular is the characteristic time evolution that the system
tends to resist the stress for considerable time, followed by sudden complete
rupture. The critical stress beyond which the complete rupture emerges is also
obtained
Putative spin liquid in the triangle-based iridate BaIrTiO
We report on thermodynamic, magnetization, and muon spin relaxation
measurements of the strong spin-orbit coupled iridate BaIrTiO,
which constitutes a new frustration motif made up a mixture of edge- and
corner-sharing triangles. In spite of strong antiferromagnetic exchange
interaction of the order of 100~K, we find no hint for long-range magnetic
order down to 23 mK. The magnetic specific heat data unveil the -linear and
-squared dependences at low temperatures below 1~K. At the respective
temperatures, the zero-field muon spin relaxation features a persistent spin
dynamics, indicative of unconventional low-energy excitations. A comparison to
the isostructural compound BaRuTiO suggests that a concerted
interplay of compass-like magnetic interactions and frustrated geometry
promotes a dynamically fluctuating state in a triangle-based iridate.Comment: Physical Review B accepte
Dynamic model for failures in biological systems
A dynamic model for failures in biological organisms is proposed and studied
both analytically and numerically. Each cell in the organism becomes dead under
sufficiently strong stress, and is then allowed to be healed with some
probability. It is found that unlike the case of no healing, the organism in
general does not completely break down even in the presence of noise. Revealed
is the characteristic time evolution that the system tends to resist the stress
longer than the system without healing, followed by sudden breakdown with some
fraction of cells surviving. When the noise is weak, the critical stress beyond
which the system breaks down increases rapidly as the healing parameter is
raised from zero, indicative of the importance of healing in biological
systems.Comment: To appear in Europhys. Let
Infrared Hall conductivity of NaCoO
We report infrared Hall conductivity of
NaCoO thin films determined from Faraday rotation angle
measurements. exhibits two types of hole
conduction, Drude and incoherent carriers. The coherent Drude carrier shows a
large renormalized mass and Fermi liquid-like behavior of Hall scattering rate,
. The spectral weight is suppressed and disappears at T
= 120K. The incoherent carrier response is centered at mid-IR frequency and
shifts to lower energy with increasing T. Infrared Hall constant is positive
and almost independent of temperature in sharp contrast with the dc-Hall
constant.Comment: 5 Pages, 5 Figures. Author list corrected in metadata only, paper is
unchange
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Organogenesis of adult lung in a dish: Differentiation, disease and therapy
The remarkable regenerative capacity of the lung suggests that stem cells could be of therapeutic importance in diverse lung diseases; however, the successful exploitation of lung stem cell biology has long been hampered by our inability to maintain and expand adult lung stem cells while retaining their multi-lineage potential . Recently, advances in our understanding of stem cell niches and the role of key signalling modulators in controlling stem cell maintenance and differentiation have fuelled the development of new three-dimensional (3D) culture technologies that sustain the stem cell-driven formation of near-physiological, self-organizing structures called organoids. Here we review basic approaches to organoid model systems and highlight recent achievements in the generation of organoids from adult stem and progenitor cells of both the murine and human lungs. We evaluate current applications in studying cellular changes in proliferation, differentiation, plasticity, and cell polarity, and cellular and molecular crosstalk of epithelial cells with stroma. Advantages and limitations of organoids for clinical use are also discussed.JC and JHL are supported by the Wellcome Trust Sir Henry Dale Fellowship that is jointly funded by the Wellcome Trust and the Royal Society (107633/Z/15/Z). EI and JHL are funded by European Research Council Starting Grant (679411)
Magneto-electric effect in NdCrTiO5
We have measured the dielectric constant and the pyroelectric current of
orthorhombic (space group ) NdCrTiO polycrystalline samples. The
dielectric constant and the pyroelectric current show features associated with
ferroelectric transitions at the antiferromagnetic transition temperature
( = 21 K). The effect of magnetic fields is to enhance the
features almost linearly up to the maximum measured field (7 T) with a
spontaneous polarization value of C/m. Two possible
scenarios, the linear magnetoelectric effect and multiferroicity
(antiferromagnetism + ferroelectricity), are discussed as possible explanations
for the observations.Comment: 7 pages, 6 figure
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