7,458 research outputs found

    Hamiltonian formalism and the Garrett-Munk spectrum of internal waves in the ocean

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    Wave turbulence formalism for long internal waves in a stratified fluid is developed, based on a natural Hamiltonian description. A kinetic equation appropriate for the description of spectral energy transfer is derived, and its self-similar stationary solution corresponding to a direct cascade of energy toward the short scales is found. This solution is very close to the high wavenumber limit of the Garrett-Munk spectrum of long internal waves in the ocean. In fact, a small modification of the Garrett-Munk formalism includes a spectrum consistent with the one predicted by wave turbulence.Comment: 4 pages latex fil

    DNA sequence duplications trigger gene inactivation in Neurospora crassa.

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    Previously Unidentified Changes in Renal Cell Carcinoma Gene Expression Identified by Parametric Analysis of Microarray Data

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    BACKGROUND. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number of genome-wide expression profiling studies have been performed. Surprisingly, there is very poor agreement among these studies as to which genes are differentially regulated. To better understand this lack of agreement we profiled renal cell tumor gene expression using genome-wide microarrays (45,000 probe sets) and compare our analysis to previous microarray studies. METHODS. We hybridized total RNA isolated from renal cell tumors and adjacent normal tissue to Affymetrix U133A and U133B arrays. We removed samples with technical defects and removed probesets that failed to exhibit sequence-specific hybridization in any of the samples. We detected differential gene expression in the resulting dataset with parametric methods and identified keywords that are overrepresented in the differentially expressed genes with the Fisher-exact test. RESULTS. We identify 1,234 genes that are more than three-fold changed in renal tumors by t-test, 800 of which have not been previously reported to be altered in renal cell tumors. Of the only 37 genes that have been identified as being differentially expressed in three or more of five previous microarray studies of renal tumor gene expression, our analysis finds 33 of these genes (89%). A key to the sensitivity and power of our analysis is filtering out defective samples and genes that are not reliably detected. CONCLUSIONS. The widespread use of sample-wise voting schemes for detecting differential expression that do not control for false positives likely account for the poor overlap among previous studies. Among the many genes we identified using parametric methods that were not previously reported as being differentially expressed in renal cell tumors are several oncogenes and tumor suppressor genes that likely play important roles in renal cell carcinogenesis. This highlights the need for rigorous statistical approaches in microarray studies.National Institutes of Healt

    Remarks on monopole charge properties within the Generalized Coherent State Model

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    The Generalized Coherent State Model, proposed previously for a unified description of magnetic and electric collective properties of nuclear systems, is used to study the ground state band charge density as well as the E0 transitions from 0β+0^+_{\beta} to 0g+0^+_g. The influence of the nuclear deformation and of angular momentum projection on the charge density is investigated. The monopole transition amplitude has been calculated for ten nuclei. The results are compared with some previous theoretical studies and with the available experimental data. Our results concerning angular momentum projection are consistent with those of previous microscopic calculations for the ground state density. The calculations for the E0 transitions agree quite well with the experimental data. Issues like how the shape transitions or shape coexistence are reflected in the ρ(E0)\rho(E0) behavior are also addressed.Comment: 32 pages, 7 figure

    Walnut agroforestry (1996)

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    Agroforestry, or growing trees and other crops together on the same land, has been practiced for years in other countries to achieve more sustainable and productive use of limited land resources. In the U.S., forestry and agriculture historically have been considered mutually exclusive land use alternatives. But with clear management objectives, careful planning and skillful intensive management, combining crops and trees can provide advantages that outweigh any perceived disadvantages. Agroforestry is a potential alternative to conventional mechanical methods for soil erosion control. It also allows for gradual removal of highly erodible cropland from row-crop production.New 1/92, Reprinted 5/96/5

    Kinematic Analysis of Obstacle Clearance During Locomotion

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    This study investigated the effect of obstacles of different heights on the locomotion of 15 healthy subjects. The following parameters were studied: (1) the distance of the toe and heel markers from the obstacle during toe-off and heel contact, respectively, (2) the minimum clearance distance of the toe and heel markers, and (3) the angular displacements and velocities of the hip, knee, and ankle. Results show significant differences in joint angular kinematics and clearance distances as obstacle height increased. The kinematic and distance differences exhibited both strong linear and non-linear trends. Toe-off distance and heel contact distance did not change significantly with changes in obstacle height
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