Ground effects induced by the 2012 seismic sequence in Emilia: implications for seismic hazard assessment in the Po Plain

Since May 16, 2012, a seismic sequence has affected a wide portion of the Emilia Region (northern Italy), chiefly for the Modena and Ferrara Provinces. The first mainshock (Ml 5.9; focal depth, ca. 6 km) occurred on May 20, 2012, with the epicenter located a few kilometers north of Finale Emilia. A second main shock (Ml 5.8; focal depth, ca. 10 km) occurred on May 29, 2012, about 12 km west of the first earthquake, with the epicenter near Medolla. The seismic sequence has been characterized by five other Ml 655 events, and more than 2,300 aftershocks of lower magnitude, until the end July 2012. The distribution of the aftershocks identifies a WNW-ESE-trending zone ca. 40 km long that is characterized by NNE-SSW nearly pure compression, as indicated by the focal mechanisms. This report focuses on the many ground effects that were induced by this seismic sequence, as mainly cracks, liquefaction-type phenomena, and hydrological anomalies. The aim is to provide a complete representation of such effects, to: illustrate their type, size and areal distribution; identify the zones in the affected area that were most prone to the occurrence of ground effects (i.e., more susceptible to local geological instability in the case of earthquake occurrence); carry out an independent assessment of the intensities of the earthquakes through the ESI 2007 intensity scale, which is based only on coseismic effects on the natural environment

Relationship of imatinib-free plasma levels and target genotype with efficacy and tolerability

Imatinib has revolutionised the treatment of chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours (GIST). Using a nonlinear mixed effects population model, individual estimates of pharmacokinetic parameters were derived and used to estimate imatinib exposure (area under the curve, AUC) in 58 patients. Plasma-free concentration was deduced from a model incorporating plasma levels of alpha1-acid glycoprotein. Associations between AUC (or clearance) and response or incidence of side effects were explored by logistic regression analysis. Influence of KIT genotype was also assessed in GIST patients. Both total (in GIST) and free drug exposure (in CML and GIST) correlated with the occurrence and number of side effects (e.g. odds ratio 2.7±0.6 for a two-fold free AUC increase in GIST; P<0.001). Higher free AUC also predicted a higher probability of therapeutic response in GIST (odds ratio 2.6±1.1; P=0.026) when taking into account tumour KIT genotype (strongest association in patients harbouring exon 9 mutation or wild-type KIT, known to decrease tumour sensitivity towards imatinib). In CML, no straightforward concentration–response relationships were obtained. Our findings represent additional arguments to further evaluate the usefulness of individualising imatinib prescription based on a therapeutic drug monitoring programme, possibly associated with target genotype profiling of patients

A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy

We provide a database of the coseismic geological surface effects following the Mw 6.5 Norcia earthquake that hit central Italy on 30 October 2016. This was one of the strongest seismic events to occur in Europe in the past thirty years, causing complex surface ruptures over an area of >400 km 2. The database originated from the collaboration of several European teams (Open EMERGEO Working Group; about 130 researchers) coordinated by the Istituto Nazionale di Geofisica e Vulcanologia. The observations were collected by performing detailed field surveys in the epicentral region in order to describe the geometry and kinematics of surface faulting, and subsequently of landslides and other secondary coseismic effects. The resulting database consists of homogeneous georeferenced records identifying 7323 observation points, each of which contains 18 numeric and string fields of relevant information. This database will impact future earthquake studies focused on modelling of the seismic processes in active extensional settings, updating probabilistic estimates of slip distribution, and assessing the hazard of surface faulting

Réactions cutanées allergiques et toxiques aux plantes [Allergic and toxic cutaneous reactions to plants]

Numerous professional or leisure activities expose individuals to plants susceptible to provoke contact allergies. The immunological mechanisms that are responsible for these ailments (delayed cellular reaction linked to allergic dermatitis or immediate IgE mediated reaction of the allergic urticaria) differ according to the plant families involved. A differential diagnosis must be made in the case of the even more frequent non-allergic reactions implying either a simple mechanical irritation, or a contact with toxic substances. The role of UV (phytophotodermatosis), as well as the contact allergy to wood is also evoked in this paper

Characterization of the Eva Verda basin aquifer (Saint Marcel, Aosta Valley, Italy) through geochemical and geostructural methods and analysis

The groundwater system of the Eva Verda basin (Saint Marcel Valley, southern side of the middle Aosta Valley, Italy) has many springs that can be used as sources for drinking water. This area is near the disused Servette mine, which can be a pollutant source (metals and sulfides) for the springs located downhill. Aquifer characterization was done using a multidisciplinary approach: geostructural, lithological, hydrogeological and geochemical. In particular, the geostructural analysis showed that the preferential water-flow direction is controlled by tectonics and that it has a trend along the slope toward the downhill springs. The mine drainage flow direction is in agreement with this trend and can pollute the springs. Chemical analysis revealed three water groups: (1) SO42-\u2013Ca2+\u2013Mg2+ rich water (mine drainage), (2) HCO3-\u2013SO42-\u2013Ca2+ rich water and (3) HCO3-\u2013Ca2+ rich water (freshwater). The second group of water results from the different percentage mix between the first and the third waters. The low percentage of mine polluted water demonstrates that there is a high dilution and low pollution of waters that can be exploited for drinking