The role of digital consciousness in change management

The article deals with the problems of change management in the new conditions of superfragility of the BANI-world. Interpretations of the concepts of “transcendental thinking”, “digital consciousness”, “immersiveness” are given. The prerequisites substantiating the idea that transcendental thinking needs to be cultivated in the organisation in order to achieve effective management flexibility are presented. The latter is formed in the broader context of the digital consciousness organisational culture, without which it is impossible to set up the organisation’s staff for a positive perception of immersive management practices and the digital technologies productive use. Barriers to the transformation of organisational processes have been identified. It has been shown that the digital transformation of the organisation increases the resistance on the part of the staff by digital resistance plane, when aversion to any change correlates with a lack of ­understanding of digital opportunities. The relationship between the conceptual methodologies of digital consciousness and metacognition and the effectiveness of the formation of a change management strategy has been established

Digital consciousness as a factor of human capital formation in integration processes

The article studies problems of reintegration of social spaces in the conditions of new reality. The concepts of “reintegration”, “digital consciousness” and “human capital” have been interpreted. The concept of reintegration process based on the multiplicative effct of resulting sum of cognitive, axiological, and organizational vectors of social space reassembly on the basis of public support for its digital transformation has been presented. The paper presents assumptions justifying the idea that achieving effctive reintegration is primarily associated with economic development of a territory so it is necessary to form human capital on the basis of digital consciousness. In the modern world, digital consciousness is becoming a dominant cognitive factor as digital technologies are increasingly penetrating our lives and changing the way people interact. However, developing digital consciousness requires continuous learning and skill development. It can be achieved through professional training, self-education, and participation in projects related to digital transformation. Thus, digital consciousness can be considered as a factor ofhuman capital growth that can help people adapt to changing labor market conditions and work successfully in digital economy

Современные концепции молекулярного патогенеза рака щитовидной железы

Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators of its morbidity and mortality rates have been increasing rapidly over the last decades. Most cases of differentiated thyroid cancer (follicular and papillary histotypes) are clinically manifested by nodular goiter frequently combined with uncertain results of cytological diagnosis (categories III and IV according to the Bethesda (Bethesda System for Reporting Thyroid Cytopathology) classification). All of that makes it difficult to choose a proper tactic for patient treatment. It is known that the development, progression, invasion, and metastasis of cancer cells are regulated by a variety of molecular mechanisms. This review describes several molecular aspects of thyroid nodules oncogenesis, as well as its most promising diagnostic tumor markers. Following molecular pathways are described in particular: gene mutations, protein tumor markers, and epigenetic effects of micro-RNA, histones, as well as DNA methylation. The study of the pathogenesis of this disease has a prognostic value and contributes to the search for effective therapeutic and diagnostic methods and their improvement. That is why we also reviewed modern test panels aimed at preoperative differential diagnosis of thyroid nodules. Summarizing the results of world research on this topic allows us not only to expand the understanding of the fundamental processes of oncogenesis, but also to outline promising areas for future experimental research projects. All of that together will contribute to developing new prognostic, diagnostic and therapeutic technologies, and as a result, will improve the quality of medical care for patients with thyroid cancer.Рак щитовидной железы – распространенное злокачественное новообразование эндокринной системы. В последние десятилетия показатели заболеваемости и смертности вследствие этой патологии стремительно увеличиваются. Большинство случаев дифференцированного рака щитовидной железы (фолликулярного и папиллярного гистотипов) клинически проявляются как узловой зоб. Неопределенность результатов цитологической диагностики (категории III и IV по классификации Bethesda (Bethesda System for Reporting Thyroid Cytopathology)) обусловливает сложности в выборе тактики ведения пациентов. Известно, что развитие, прогрессирование, инвазия и метастазирование раковых клеток регулируются множеством молекулярных механизмов. В данной статье описываются некоторые молекулярные аспекты онкогенеза узловых образований щитовидной железы, а также наиболее перспективные диагностические онкомаркеры. В частности, рассматривается роль генных мутаций, белковых маркеров, эпигенетических воздействий микроРНК, гистонов и метилирования ДНК в патогенезе рака щитовидной железы. Изучение патогенеза этого заболевания имеет прогностическую ценность и способствует поиску эффективных лечебно-диагностических методов и их совершенствованию. Поэтому в исследовании были рассмотрены применяемые в настоящий момент тест-панели, направленные на дооперационную дифференциальную диагностику узловых образований щитовидной железы. Анализ и обобщение результатов исследований по данной теме позволят не только расширить понимание фундаментальных процессов онкогенеза, но и наметить перспективные направления планирования экспериментальных научных работ для разработки новых прогностических, диагностических и терапевтических технологий с целью повышения качества медицинской помощи пациентам с раком щитовидной железы

High-dose rate brachytherapy in the treatment of cancer of the cervix uteri

Analysis of the results of examining and treating 246 patients with Stages IIA-IIIB cancer of the cervix uteri (CCU), receiving specific chemoradiotherapy (CRT) at the Department of Radiotherapy, National Oncology Center (Baku), has ascertained that CRT using two high-dose (9 Gy) rate brachytherapy fractions and competitive cisplatin chemotherapy is an effective, reasonably safe, and economically sound treatment method for locally advanced CCU. The method shows acceptable toxicity and may be used in routine clinical practice

The first experience of the use of two-fraction adaptive intracavitary/interstitial brachytherapy in the treatment of cervical cancer

Aim. The study of the results of chemoradiotherapy for cervical cancer with the use of two-fraction brachytherapy. Methods. The article presents analysis of the examination and treatment results of 17 patients with IIB-IIIB stage cervical cancer. The average age was 51±4.6 years (44 to 62 years). External beam radiotherapy was performed with single boost dose of 1.8 Gy to total dose of 45 Gy. Also the patients received 40 mg/m2 of weekly cisplatin. Intracavitary/interstitial high dose-rate brachytherapy with insertion of parametrial needles consisted of two weekly fractions of 10.0 Gy. Results. Due to the use of interstitial needles the average dose was 82.2 Gy when recalculated to classical 2 Gy fractions. The median follow up was 16±3,2 months. The used radiotherapy modality for cervical cancer allowed achieving complete tumor involution in 16 (94.1%) patients and partial involution only in 1 (5.9%) case. All females had favorable tolerance and received the entire regimen of planned radiation. Conclusion. The first experience of the use of concurrent chemoradiotherapy for locally advanced cervical cancer with external beam radiotherapy, two-fraction intracavitary/interstitial adaptive brachytherapy with single boost dose of 10 Gy and 5 weekly infusions of 40 mg/m2 of cisplatin showed high probability of complete and partial tumor response rate with favorable tolerance and acceptable incidence and severity of toxicity

Synthesis and characterization of CdS nanoparticle based multiwall carbon nanotube-maleic anhydride-1-octene nanocomposites

CdS nanoparticles were synthesized by sonication from cadmium chloride and thiourea using a multiwall carbon nanotube (MWCNT)-maleic anhydride (MA)-1-octene system as the matrix. The matrix was obtained by the "grafting from" approach from oxidized carbon nanotubes and maleic anhydride-1-octene. Multiwall carbon nanotubes used for reinforcing the matrix were synthesized by Catalytic Chemical Vapor Deposition using Fe-Co/Al2O3 as the catalyst. The obtained nanostructures were characterized by FTIR, XRD, Raman spectroscopy, TEM, SEM and UV-vis spectroscopy. The average CdS particle diameter was 7.9 nm as confirmed independently by TEM and XRD. UV-vis spectroscopy revealed that the obtained nanostructure is an appropriate base material for making optical devices. The novelty of this work is the use of the MWCNT-MA-1-octene matrix obtained via the "grafting from" approach for the synthesis of uniformly dispersed CdS nanocrystals by ultrasonic cavitation to obtain a polymer nanocomposite. (C) 2015 Elsevier B.V. All rights reserved

Antibiotic therapy for acute respiratory viral infections in children:what do parents know about antibiotics and antibiotic resistance?

One of the causes of antibiotic resistance (AR) is irrational use of antibiotics (ABs) that are commonly administered to patients with acute respiratory viral infections (ARVIs). Rational AB use largely depends on the awareness of people. Objective. To analyze the awareness of people about AR and AB use, as well as to assess the attitude to AB therapy among parents of preschool children. Materials and methods. We conducted anonymous survey among 513 parents of preschool children in Tomsk. Results. Almost two-thirds (61.6%) of respondents admitted that their children received AB during cold/flu/ARVI. The most commonly used ABs were amoxicillin (62.3%), azithromycin (19.7%), and amoxicillin with clavulanic acid (11.1%). The majority of patients administered ABs to their children only after doctor's prescription (80.4%) and adhered to treatment regimen (79.7%). A total of 65.8% respondents stated that doctors had explained why AB therapy was necessary. Nearly two out of three parents (62.4%) believed that ABs may have a negative impact on health. More than half of the respondents were aware of AR. Conclusion. The majority of parents use antibiotics to treat ARVI in their children only with doctor's prescription. However, we observed insufficient awareness about AR, AB use, and possible side effects, which necessitates the development of educational programs for the population