Experimental assessment of the speed of light perturbation in free-fall absolute gravimeters

Precision absolute gravity measurements are growing in importance, especially in the context of the new definition of the kilogram. For the case of free-fall absolute gravimeters with a Michelson-type interferometer tracking the position of a free falling body, one of the effects that needs to be taken into account is the speed of light perturbation due to the finite speed of propagation of light. This effect has been extensively discussed in the past, and there is at present a disagreement between different studies. In this work, we present the analysis of new data and confirm the result expected from the theoretical analysis applied nowadays in free-fall gravimeters. We also review the standard derivations of this effect (by using phase shift or Doppler effect arguments) and show their equivalence

SAVERS: SAR ATR with Verification Support Based on Convolutional Neural Network

We propose a new convolutional neural network (CNN) which performs coarse and fine segmentation for end-to-end synthetic aperture radar (SAR) automatic target recognition (ATR) system. In recent years, many CNNs for SAR ATR using deep learning have been proposed, but most of them classify target classes from fixed size target chips extracted from SAR imagery. On the other hand, we proposed the CNN which outputs the score of the multiple target classes and a background class for each pixel from the SAR imagery of arbitrary size and multiple targets as fine segmentation. However, it was necessary for humans to judge the CNN segmentation result. In this report, we propose a CNN called SAR ATR with verification support (SAVERS), which performs region-wise (i.e. coarse) segmentation and pixel-wise segmentation. SAVERS discriminates between target and non-target, and classifies multiple target classes and non-target class by coarse segmentation. This report describes the evaluation results of SAVERS using the Moving and Stationary Target Acquisition and Recognition (MSTAR) dataset.Comment: Technical Report, 6 pages, 8 figures, 5 tables, Copyright(C)2018 IEICE. arXiv admin note: substantial text overlap with arXiv:1801.0855

Increased prevalence of Borrelia burgdorferi infections in Bernese Mountain Dogs: a possible breed predisposition

BACKGROUND: Glomerulonephritis in dogs has been associated with B. burgdorferi infections. In Bernese Mountain Dogs with glomerulonephritis antibodies against B. burgdorferi were found in most dogs, raising the question if the breed is predisposed to infections with B. burgdorferi. The aim of this study was to determine the prevalence of antibodies against B. burgdorferi sensu lato in a well defined population of Bernese Mountain Dogs and to compare this prevalence with data from dogs of other breeds. RESULTS: 160 Bernese Mountain Dogs and 62 control dogs (large breed dogs with long hair) were included. All dogs were considered healthy according to a questionnaire filled out by the owner, complete blood count, chemistry panel, urinalysis and urine culture. Bernese Mountain Dogs and control dogs were kept similar in similar environments. Seroprevalence of B. burgdorferi was assessed by ELISA and Western blot and was 58% in Bernese Mountain Dogs compared to 15% in control dogs. This difference was significant. Neither antibodies against leptospires nor vaccination or hair coat color influenced the results. CONCLUSIONS: The cause of the considerably higher prevalence of antibodies against B. burgdorferi in Bernese Mountain Dogs and its consequences are not known. A breed predisposition can be suspected

Follow-up of Bernese Mountain dogs and other dogs with serologically diagnosed Borrelia burgdorferi infection: What happens to seropositive animals?

<p>Abstract</p> <p>Background</p> <p>Data on the long-term outcome of <it>B. burgdorferi </it>infections in adult dogs are sparse. The aim of the present study was to investigate whether Bernese Mountain dogs with serological evidence of natural <it>B. burgdorferi </it>infection more often develop signs such as lameness, azotemia or proteinuria during a follow-up period of 2.5 to 3.0 years. Seropositive Bernese Mountain dogs were compared to seronegative Bernese Mountain dogs and to seropositive and seronegative control dogs of other breeds.</p> <p>Dogs included in a previous study on the prevalence of antibodies against <it>B. burgdorferi </it>in Bernese Mountain dogs were re-evaluated. Antibodies against <it>B. burgdorferi </it>were determined using an ELISA with a whole-cell sonicate as antigen and results were confirmed using a Western blot assay.</p> <p>Results</p> <p>Fifty-three Bernese Mountain dogs and 30 control dogs were re-evaluated. Re-evaluation was performed between 2.5 and 3.0 years (median 2.7 years) after the first assessment.</p> <p>The age of the dogs at the second evaluation ranged from 3 to 11 years (median 6 years). There were no significant differences with regard to poor general condition or lameness between the first and the second evaluation.</p> <p>At the first evaluation 22 (42%) of the Bernese Mountain dogs and 11 (37%) of the control dogs were considered positive for antibodies against <it>B. burgdorferi</it>. At the second evaluation 25 (47%) of the Bernese Mountain dogs and 12 (40%) of the control dogs were considered positive; 69% of the dogs showed the same serological result at both examinations and 31% were seroconverted or seroreverted. During the first examination, azotemia was diagnosed in 6 Bernese Mountain dogs and during the second examination in 11 Bernese Mountain dogs. No control dogs had azotemia in this study. In seropositive dogs there was no increase in lameness or signs of renal disease over time.</p> <p>Conclusion</p> <p>It may be concluded that antibodies against <it>B. burgdorferi </it>determined by whole cell ELISA and confirmed by Western blot were neither associated with the development of lameness nor with signs of renal disease like azotemia or proteinuria in dogs observed over a period of 2.5 to 3.0 years.</p

Follow-up of Bernese Mountain dogs and other dogs with serologically diagnosed Borrelia burgdorferi infection: what happens to seropositive animals?

BACKGROUND: Data on the long-term outcome of B. burgdorferi infections in adult dogs are sparse. The aim of the present study was to investigate whether Bernese Mountain dogs with serological evidence of natural B. burgdorferi infection more often develop signs such as lameness, azotemia or proteinuria during a follow-up period of 2.5 to 3.0 years. Seropositive Bernese Mountain dogs were compared to seronegative Bernese Mountain dogs and to seropositive and seronegative control dogs of other breeds. Dogs included in a previous study on the prevalence of antibodies against B. burgdorferi in Bernese Mountain dogs were re-evaluated. Antibodies against B. burgdorferi were determined using an ELISA with a whole-cell sonicate as antigen and results were confirmed using a Western blot assay. RESULTS: Fifty-three Bernese Mountain dogs and 30 control dogs were re-evaluated. Re-evaluation was performed between 2.5 and 3.0 years (median 2.7 years) after the first assessment.The age of the dogs at the second evaluation ranged from 3 to 11 years (median 6 years). There were no significant differences with regard to poor general condition or lameness between the first and the second evaluation. At the first evaluation 22 (42%) of the Bernese Mountain dogs and 11 (37%) of the control dogs were considered positive for antibodies against B. burgdorferi. At the second evaluation 25 (47%) of the Bernese Mountain dogs and 12 (40%) of the control dogs were considered positive; 69% of the dogs showed the same serological result at both examinations and 31% were seroconverted or seroreverted. During the first examination, azotemia was diagnosed in 6 Bernese Mountain dogs and during the second examination in 11 Bernese Mountain dogs. No control dogs had azotemia in this study. In seropositive dogs there was no increase in lameness or signs of renal disease over time. CONCLUSION: It may be concluded that antibodies against B. burgdorferi determined by whole cell ELISA and confirmed by Western blot were neither associated with the development of lameness nor with signs of renal disease like azotemia or proteinuria in dogs observed over a period of 2.5 to 3.0 years

Phase-coherence threshold and vortex-glass state in diluted Josephson-junction arrays in a magnetic field

We study numerically the interplay of phase coherence and vortex-glass state in two-dimensional Josephson-junction arrays with average rational values of flux quantum per plaquette $f$ and random dilution of junctions. For $f=1/2$, we find evidence of a phase coherence threshold value $x_s$, below the percolation concentration of diluted junctions $x_p$, where the superconducting transition vanishes. For $x_s < x < x_p$ the array behaves as a zero-temperature vortex glass with nonzero linear resistance at finite temperatures. The zero-temperature critical currents are insensitive to variations in $f$ in the vortex glass region while they are strongly $f$ dependent in the phase coherent region.Comment: 6 pages, 4 figures, to appear in Phys. Rev.

Inhaled nitric oxide for high-altitude pulmonary edema

BACKGROUND. Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. When administered by inhalation, nitric oxide, an endothelium-derived relaxing factor, attenuates the pulmonary vasoconstriction produced by short-term hypoxia. METHODS. We studied the effects of inhaled nitric oxide on pulmonary-artery pressure and arterial oxygenation in 18 mountaineers prone to high-altitude pulmonary edema and 18 mountaineers resistant to this condition in a high altitude laboratory (altitude, 4559 m). We also obtained lung-perfusion scans before and during nitric oxide inhalation to gain further insight into the mechanism of action of nitric oxide. RESULTS. In the high-altitude laboratory, subjects prone to high-altitude pulmonary edema had more pronounced pulmonary hypertension and hypoxemia than subjects resistant to high-altitude pulmonary edema. Arterial oxygen saturation was inversely related to the severity of pulmonary hypertension (r=-0.50, P=0.002). In subjects prone to high-altitude pulmonary edema, the inhalation of nitric oxide (40 ppm for 15 minutes) produced a decrease in mean (+/-SD) systolic pulmonary-artery pressure that was three times larger than the decrease in subjects resistant to such edema (25.9+/-8.9 vs. 8.7+/-4.8 mm Hg, P&lt;0.001). Inhaled nitric oxide improved arterial oxygenation in the 10 subjects who had radiographic evidence of pulmonary edema (arterial oxygen saturation increased from 67+/-10 to 73+/-12 percent, P=0.047), whereas it worsened oxygenation in subjects resistant to high-altitude pulmonary edema. The nitric oxide-induced improvement in arterial oxygenation in subjects with high-altitude pulmonary edema was accompanied by a shift in blood flow in the lung away from edematous segments and toward nonedematous segments. CONCLUSIONS. The inhalation of nitric oxide improves arterial oxygenation in high-altitude pulmonary edema, and this beneficial effect may be related to its favorable action on the distribution of blood flow in the lungs. A defect in nitric nitric oxide synthesis may contribute to high-altitude pulmonary edema

Diluted Josephson-junction arrays in a magnetic field: phase coherence and vortex glass thresholds

The effects of random dilution of junctions on a two-dimensional Josephson-junction array in a magnetic field are considered. For rational values of the average flux quantum per plaquette $f$, the superconducting transition temperature vanishes, for increasing dilution, at a critical value $x_S(f)$, while the vortex ordering remains stable up to $x_{VL}>x_S$, much below the value $x_p$ corresponding to the geometric percolation threshold. For $x_{VL}<x<x_p$, the array behaves as a zero-temperature vortex-glass. Numerical results for $f=1/2$ from defect energy calculations are presented which are consistent with this scenario.Comment: 4 pages, 4 figures, to appear in Phys. Rev.

The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis

Anthocyanins are ubiquitous plant pigments used in a variety of technological applications. Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins attributed to the action of leucoanthocyanidin dioxygenase has never been efficiently reconstituted outside plants, preventing the construction of heterologous cell factories. Through biochemical and structural analysis, here we show that anthocyanin-related glutathione transferases, currently implicated only in anthocyanin transport, catalyse an essential dehydration of the leucoanthocyanidin dioxygenase product, flavan-3,3,4-triol, to generate cyanidin. Building on this knowledge, introduction of anthocyanin-related glutathione transferases into a heterologous biosynthetic pathway in baker's yeast results in >35-fold increased anthocyanin production. In addition to unravelling the long-elusive anthocyanin biosynthesis, our findings pave the way for the colourants' heterologous microbial production and could impact the breeding of industrial and ornamental plants

Current-voltage characteristics of diluted Josephson-junction arrays: scaling behavior at current and percolation threshold

Dynamical simulations and scaling arguments are used to study the current-voltage (IV) characteristics of a two-dimensional model of resistively shunted Josephson-junction arrays in presence of percolative disorder, at zero external field. Two different limits of the Josephson-coupling concentration $p$ are considered, where $p_c$ is the percolation threshold. For $p$ $>$ $p_c$ and zero temperature, the IV curves show power-law behavior above a disorder dependent critical current. The power-law behavior and critical exponents are consistent with a simple scaling analysis. At $p_c$ and finite temperature $T$, the results show the scaling behavior of a T=0 superconducting transition. The resistance is linear but vanishes for decreasing $T$ with an apparent exponential behavior. Crossover to non-linearity appears at currents proportional to $$, with a thermal-correlation length exponent $\nu_T$ consistent with the corresponding value for the diluted XY model at $p_c$.Comment: Revtex, 9 postscript pages, to appear in Phys. Rev.