Stand-alone flat-plate photovoltaic power systems: System sizing and life-cycle costing methodology for Federal agencies

A simple methodology to estimate photovoltaic system size and life-cycle costs in stand-alone applications is presented. It is designed to assist engineers at Government agencies in determining the feasibility of using small stand-alone photovoltaic systems to supply ac or dc power to the load. Photovoltaic system design considerations are presented as well as the equations for sizing the flat-plate array and the battery storage to meet the required load. Cost effectiveness of a candidate photovoltaic system is based on comparison with the life-cycle cost of alternative systems. Examples of alternative systems addressed are batteries, diesel generators, the utility grid, and other renewable energy systems

Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells

Obesity and type 2 diabetes lead to dramatically increased risks of atherosclerosis and CHD. Multiple mechanisms converge to promote atherosclerosis by increasing endothelial oxidative stress and up-regulating expression of pro-inflammatory molecules. Microvesicles (MV) are small ( < 1 μm) circulating particles that transport proteins and genetic material, through which they are able to mediate cell–cell communication and influence gene expression. Since MV are increased in plasma of obese, insulin-resistant and diabetic individuals, who often exhibit chronic vascular inflammation, and long-term feeding of a high-fat diet (HFD) to rats is a well-described model of obesity and insulin resistance, we hypothesised that this may be a useful model to study the impact of MV on endothelial inflammation. The number and cellular origin of MV from HFD-fed obese rats were characterised by flow cytometry. Total MV were significantly increased after feeding HFD compared to feeding chow (P< 0·001), with significantly elevated numbers of MV derived from leucocyte, endothelial and platelet compartments (P< 0·01 for each cell type). MV were isolated from plasma and their ability to induce reactive oxygen species (ROS) formation and vascular cell adhesion molecule (VCAM)-1 expression was measured in primary rat cardiac endothelial cells in vitro. MV from HFD-fed rats induced significant ROS (P< 0·001) and VCAM-1 expression (P= 0·0275), indicative of a pro-inflammatory MV phenotype in this model of obesity. These findings confirm that this is a useful model to further study the mechanisms by which diet can influence MV release and subsequent effects on cardio-metabolic health

A V-Diagram for the Design of Integrated Health Management for Unmanned Aerial Systems

Designing Integrated Vehicle Health Management (IVHM) for Unmanned Aerial Systems (UAS) is inherently complex. UAS are a system of systems (SoS) and IVHM is a product-service, thus the designer has to take into account many factors, such as: the design of the other systems of the UAS (e.g. engines, structure, communications), the split of functions between elements of the UAS, the intended operation/mission of the UAS, the cost verses benefit of monitoring a system/component/part, different techniques for monitoring the health of the UAS, optimizing the health of the fleet and not just the individual UAS, amongst others. The design of IVHM cannot sit alongside, or after, the design of UAS, but itself be integrated into the overall design to maximize IVHM’s potential. Many different methods exist to help design complex products and manage the process. One method used is the V-diagram which is based on three concepts: decomposition & definition; integration & testing; and verification & validation. This paper adapts the V-diagram so that it can be used for designing IVHM for UAS. The adapted v-diagram splits into different tracks for the different system elements of the UAS and responses to health states (decomposition and definition). These tracks are then combined into an overall IVHM provision for the UAS (integration and testing), which can be verified and validated. The stages of the adapted V-diagram can easily be aligned with the stages of the V-diagram being used to design the UAS bringing the design of the IVHM in step with the overall design process. The adapted V-diagram also allows the design IVHM for a UAS to be broken down in to smaller tasks which can be assigned to people/teams with the relevant competencies. The adapted V-diagram could also be used to design IVHM for other SoS and other vehicles or products

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD

Accelerated Test Development for Coil-coated Steel Building Panels

This paper discusses the experimental design and the preliminary findings of an ongoing project designed to establish an accelerated laboratory test that would rank coating system performance the same as their performance in atmospheric exposure. A total of ten materials are included in the program: four substrates each with two coating systems and one substrate with two additional coating systems. Samples were installed at four atmospheric exposure sites: Middletown, OH, Daytona Beach, FL, Monroeville, PA, and Halifax, NS, Canada. Three different orientations were utilized at each of the exposure sites and a variety of building panel features were included on the test panels (roll formed bends, laps, cut drip edges, standing seam closures, and scribes). The work discussed in this paper includes the program design and implementation and preliminary correlation\u27s of the three-year atmospheric exposure results to several standard accelerated test methods including: ASTM B117, ASTM G85, ASTM G87, and GM 9540

Topological Defects and Gapless Modes in Insulators and Superconductors

We develop a unified framework to classify topological defects in insulators and superconductors described by spatially modulated Bloch and Bogoliubov de Gennes Hamiltonians. We consider Hamiltonians H(k,r) that vary slowly with adiabatic parameters r surrounding the defect and belong to any of the ten symmetry classes defined by time reversal symmetry and particle-hole symmetry. The topological classes for such defects are identified, and explicit formulas for the topological invariants are presented. We introduce a generalization of the bulk-boundary correspondence that relates the topological classes to defect Hamiltonians to the presence of protected gapless modes at the defect. Many examples of line and point defects in three dimensional systems will be discussed. These can host one dimensional chiral Dirac fermions, helical Dirac fermions, chiral Majorana fermions and helical Majorana fermions, as well as zero dimensional chiral and Majorana zero modes. This approach can also be used to classify temporal pumping cycles, such as the Thouless charge pump, as well as a fermion parity pump, which is related to the Ising non-Abelian statistics of defects that support Majorana zero modes.Comment: 27 pages, 15 figures, Published versio

Hunters and gatherers: Strategies for curriculum mapping and data collection for assuring learning

Assurance of learning is a predominant feature in both quality enhancement and assurance in higher education. Assurance of learning is a process that articulates explicit program outcomes and standards, and systematically gathers evidence to determine the extent to which performance matches expectations. Benefits accrue to the institution through the systematic assessment of whole of program goals. Data may be used for continuous improvement, program development, and to inform external accreditation and evaluation bodies. Recent developments, including the introduction of the Tertiary Education and Quality Standards Agency (TEQSA) will require universities to review the methods they use to assure learning outcomes. This project investigates two critical elements of assurance of learning: 1. the mapping of graduate attributes throughout a program; and 2. the collection of assurance data. An audit was conducted with twenty five Business Schools in Australian universities to identify current methods of mapping graduate attributes across degree programs and their impact on the curriculum, followed by a review of the systems used to collect and store data. Our findings indicate that external drivers like professional body accreditation (for example: Chartered Professional Accountants (CPA); Association to Advance Collegiate Schools of Business (AACSB)) and TEQSA are important motivators for assuring learning, and those who were undertaking AACSB accreditation had more robust assurance of learning systems in place. It was reassuring to see that the majority of institutions (96%) had adopted an embedding approach to assuring learning rather than opting for independent standardised testing. The main challenges that were evident were the development of sustainable processes not considered a burden to academic staff, and obtainment of academic buy in to the benefits of assuring learning rather than assurance being seen as a tick box exercise. This cultural change is the real challenge in assurance of learning practice

Turbulent Flow-Driven Molecular Cloud Formation: A Solution to the Post-T Tauri Problem?

We suggest that molecular clouds can be formed on short time scales by compressions from large scale streams in the interstellar medium (ISM). In particular, we argue that the Taurus-Auriga complex, with filaments of 10-20 pc $\times$ 2-5 pc, most have been formed by H I flows in $\lesssim 3$Myr, explaining the absence of post-T Tauri stars in the region with ages $\gtrsim 3$ Myr. Observations in the 21 cm line of the H I `halos' around the Taurus molecular gas show many features (broad asymmetric profiles, velocity shifts of H I relative to $^{12}$CO) predicted by our MHD numerical simulations, in which large-scale H I streams collide to produce dense filamentary structures. This rapid evolution is possible because the H I flows producing and disrupting the cloud have much higher velocities (5-10 kms) than present in the molecular gas resulting from the colliding flows. The simulations suggest that such flows can occur from the global ISM turbulence without requiring a single triggering event such as a SN explosion.Comment: 26 pages, 12 ps figures. Apj accepte