Iron oxide-based nanomagnets in nanomedicine: fabrication and applications

Iron oxide-based nanomagnets have attracted a great deal of attention in nanomedicine over the past decade. Down to the nanoscale, superparamagnetic iron oxide nanoparticles can only be magnetized in the presence of an external magnetic field, which makes them capable of forming stable colloids in a physio-biological medium. Their superparamagnetic property, together with other intrinsic properties, such as low cytotoxicity, colloidal stability, and bioactive molecule conjugation capability, makes such nanomagnets ideal in both in-vitro and in-vivo biomedical applications. In this review, a chemical, physical, and biological synthetic approach to prepare iron oxide-based nanomagnets with different physicochemical properties was illustrated and compared. The growing interest in iron oxide-based nanomagnets with multifunctionalities was explored in cancer diagnostics and treatment, focusing on their combined roles in a magnetic resonance contrast agent, hyperthermia, and magnetic force assisted drug delivery. Iron oxides as magnetic carriers in gene therapy were reviewed with a focus on the sophisticated design and construction of magnetic vectors. Finally, the iron oxide-based nanomagnet also represents a very promising tool in particle/cell interfacing in controlling cellular functionalities, such as adhesion, proliferation, differentiation, and cell patterning, in stem cell therapy and tissue engineering applications

Second discontinuity in the specific heat of two-phase superconductors

The recently proposed theoretical model of superconductors endowed with two distinct superconducting phases and critical temperatures is further analyzed by introducing two distinct order parameters, described by two scalar fields which condensate at different temperatures. We find some deviations in basic thermodynamical quantities with respect to the Ginzburg-Landau one-phase superconductors. In particular, by contrast to the usual case where only one jump in specific heat takes place at the normal-superconductor transition temperature, we actually predict an additional discontinuity for C_V when passing from a superconducting phase to the other one.Comment: revtex, 4 pages, 1 figur

Magnetic properties of two-phase superconductors

We have recently proposed a theoretical model for superconductors endowed with two distinct superconducting phases, described by two scalar order parameters which condensate at different critical temperatures. On analyzing the magnetic behavior of such systems, we have found some observable differences with respect to the case of ordinary Ginzburg-Landau superconductors. In particular, at low temperature the London penetration length is strongly reduced and the Ginzburg-Landau parameter k becomes a function of temperature. By contrast, in the temperature region between the two phase transitions k is constant and the system is a type-I or a type-II superconductor depending on the ratio between the critical temperatures.Comment: revtex, 5 pages, 1 eps figur

Electron-phonon interaction in transition metal diborides TB_2 (T=Zr, Nb, Ta) studied by point-contact spectroscopy

The electron-phonon interaction (EPI) in transition metal diborides TB_2 (T=Zr, Nb, Ta) is investigated by point-contact (PC) spectroscopy. The PC EPI functions were recovered and the EPI parameters lambda<0.1 were estimated for all three compounds. Common and distinctive features between the EPI functions for those diborides are discussed also in connection with the superconductivity in MgB_2.Comment: V2: minor changes, Ref.[21] added, publ. in PR

Assembling the puzzle of superconducting elements: A Review

Superconductivity in the simple elements is of both technological relevance and fundamental scientific interest in the investigation of superconductivity phenomena. Recent advances in the instrumentation of physics under pressure have enabled the observation of superconductivity in many elements not previously known to superconduct, and at steadily increasing temperatures. This article offers a review of the state of the art in the superconductivity of elements, highlighting underlying correlations and general trends.Comment: Review, 10 pages, 11 figures, 97 references; to appear in Superc. Sci. Techno

Prospects for Improving the Intrinsic and Extrinsic Properties of Magnesium Diboride Superconducting Strands

The magnetic and transport properties of magnesium diboride films represent performance goals yet to be attained by powder-processed bulk samples and conductors. Such performance limits are still out of the reach of even the best magnesium diboride magnet wire. In discussing the present status and prospects for improving the performance of powder-based wire we focus attention on (1) the intrinsic (intragrain) superconducting properties of magnesium diboride, Hc2 and flux pinning, (2) factors that control the efficiency with which current is transported from grain-to-grain in the conductor, an extrinsic (intergrain) property. With regard to Item-(1), the role of dopants in Hc2 enhancement is discussed and examples presented. On the other hand their roles in increasing Jc, both via Hc2 enhancement as well as direct fluxoid/pining-center interaction, are discussed and a comprehensive survey of Hc2 dopants and flux-pinning additives is presented. Current transport through the powder-processed wire (an extrinsic property) is partially blocked by the inherent granularity of the material itself and the chemical or other properties of the intergrain surfaces. These and other such results indicate that in many cases less than 15% of the conductor's cross sectional area is able to carry transport current. It is pointed out that densification in association with the elimination of grain-boundary blocking phases would yield five-to ten-fold increases in Jc in relevant regimes, enabling the performance of magnesium diboride in selected applications to compete with that of Nb-Sn

Global Ethics and Nanotechnology: A Comparison of the Nanoethics Environments of the EU and China

The following article offers a brief overview of current nanotechnology policy, regulation and ethics in Europe and The People’s Republic of China with the intent of noting (dis)similarities in approach, before focusing on the involvement of the public in science and technology policy (i.e. participatory Technology Assessment). The conclusions of this article are, that (a) in terms of nanosafety as expressed through policy and regulation, China PR and the EU have similar approaches towards, and concerns about, nanotoxicity—the official debate on benefits and risks is not markedly different in the two regions; (b) that there is a similar economic drive behind both regions’ approach to nanodevelopment, the difference being the degree of public concern admitted; and (c) participation in decision-making is fundamentally different in the two regions. Thus in China PR, the focus is on the responsibility of the scientist; in the EU, it is about government accountability to the public. The formulation of a Code of Conduct for scientists in both regions (China PR’s predicted for 2012) reveals both similarity and difference in approach to nanotechnology development. This may change, since individual responsibility alone cannot guide S&T development, and as public participation is increasingly seen globally as integral to governmental decision-making

Two band gap field-dependent thermal conductivity of MgB2MgB_2

The thermal conductivity $\kappa (H,T)$ of the new superconductor $MgB_2$ was studied as a function of the temperature and a magnetic field. No anomaly in the thermal conductivity $\kappa (H,T)$ is observed around the superconducting transition in absence or presence of magnetic fields up to 14 Tesla; upon that field the superconductivity of $MgB_2$ persisted. The thermal conductivity in zero-field shows a $T$-linear increase up to 50K. The thermal conductivity is found to increase with increasing field at high fields. We interpret the findings as if there are two subsystems of quasiparticles with different field-dependent characters in a two ($L$ and $S$)-band superconductor reacting differently with the vortex structure. The unusual enhancement of $\kappa (H ,T)$ at low temperature but higher than a ($H_{c2S}\simeq 3T$) critical field is interpreted as a result of the overlap of the low energy states outside the vortex cores in the $S$-band.Comment: 6 pages,3 figure

Isotope Effect in the Presence of Magnetic and Nonmagnetic Impurities

The effect of impurities on the isotope coefficient is studied theoretically in the framework of Abrikosov-Gor'kov approach generalized to account for both potential and spin-flip scattering in anisotropic superconductors. An expression for the isotope coefficient as a function of the critical temperature is obtained for a superconductor with an arbitrary contribution of spin-flip processes to the total scattering rate and an arbitrary degree of anisotropy of the superconducting order parameter, ranging from isotropic s-wave to d-wave and including anisotropic s-wave and mixed (s+d)-wave as particular cases. It is found that both magnetic and nonmagnetic impurities enhance the isotope coefficient, the enhancement due to magnetic impurities being generally greater than that due to nonmagnetic impurities. From the analysis of the experimental results on La-Sr-Cu-M-O high temperature superconductor, it is concluded that the symmetry of the pairing state in this system differs from a pure d-wave.Comment: 4 pages, 3 figure

A magnetization and 11^{11}B NMR study of Mg1−x_{1-x}Alx_xB2_2 superconductors

We demonstrate for the first time the magnetic field distribution of the pure vortex state in lightly doped Mg$_{1-x}$Al$_x$B$_2$ ($x\leq 0.025$) powder samples, by using $^{11}$B NMR in magnetic fields of 23.5 and 47 kOe. The magnetic field distribution at T=5 K is Al-doping dependent, revealing a considerable decrease of anisotropy in respect to pure MgB$_2$. This result correlates nicely with magnetization measurements and is consistent with $\sigma$-band hole driven superconductivity for MgB$_2$