Industrial Development Policies and Performances in Southern China: Beyond the Specialised Industrial Cluster Program

none3The paper offers an updated picture of the policies implemented by the government of the Guangdong Province (China) to foster the industrial development and the technological upgrading of its territories. Among these policies is the promotion and the institutional acknowledgement of a growing number of industrial clusters, defined as “specialized towns”, characterized by a high spatial concentration of firms producing one specific item (or a limited range of similar products). In the view of the provincial and local governments these types of industrial development programs are used to increase firms agglomerations, spatial concentration and visibility, which in turn leads to increased specialization, industrial output, innovation and economic growth. However, little specific empirical evidence has been collected to support this view and the debate, at the national and international level, on the effectiveness of such interventions seems to be still largely ideological. The paper offers a contribution in this sense by offering a detailed description of the policy tools, by suggesting synthetic indexes to quantify policy efforts and industrial performances in Guangdong territories and by providing a first statistical analysis of these indexesmixedBarbieri E.; Di Tommaso M.R.; Bonnini S.Barbieri, Elisa; DI TOMMASO, Marco Rodolfo; Bonnini, Stefan

Novel near-infrared emission from crystal defects in MoS2 multilayer flakes

The structural defects in two-dimensional transition metal dichalcogenides, including point defects, dislocations and grain boundaries, are scarcely considered regarding their potential to manipulate the electrical and optical properties of this class of materials, notwithstanding the significant advances already made. Indeed, impurities and vacancies may influence the exciton population, create disorder-induced localization, as well as modify the electrical behaviour of the material. Here we report on the experimental evidence, confirmed by ab initio calculations, that sulfur vacancies give rise to a novel near-infrared emission peak around 0.75 eV in exfoliated MoS2 flakes. In addition, we demonstrate an excess of sulfur vacancies at the flake's edges by means of cathodoluminescence mapping, aberration-corrected transmission electron microscopy imaging and electron energy loss analyses. Moreover, we show that ripplocations, extended line defects peculiar to this material, broaden and redshift the MoS2 indirect bandgap emission

Focusing effect of bent GaAs crystals for γ-ray Laue lenses: Monte Carlo and experimental results

We report on results of observation of the focusing effect from the planes (220) of Gallium Arsenide (GaAs) crystals. We have compared the experimental results with the Monte Carlo simulations of the focusing capability of GaAs tiles performed with a dedicated ray-tracer. The GaAs tiles were bent using a lapping process developed at the cnr/imem - Parma (Italy) in the framework of the laue project, funded by ASI, dedicated to build a broad band Laue lens prototype for astrophysical applications in the hard X-/soft γ-ray energy range (80-600 keV). We present and discuss the results obtained from their characterization, mainly in terms of focusing capability. Bent crystals will significantly increase the signal to noise ratio of a telescope based on a Laue lens, consequently leading to an unprecedented enhancement of sensitivity with respect to the present non focusing instrumentation

Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy

PURPOSE: The purpose of this study was to evaluate a set of widely used nuclear medicine imaging agents as possible methods to study the early effects of systemic inflammation on the living brain in a mouse model of sepsis-associated encephalopathy (SAE). The lipopolysaccharide (LPS)-induced murine systemic inflammation model was selected as a model of SAE. PROCEDURES: C57BL/6 mice were used. A multimodal imaging protocol was carried out on each animal 4 h following the intravenous administration of LPS using the following tracers: [(99m)Tc][2,2-dimethyl-3-[(3E)-3-oxidoiminobutan-2-yl]azanidylpropyl]-[(3E)-3-hyd roxyiminobutan-2-yl]azanide ([(99m)Tc]HMPAO) and ethyl-7-[(125)I]iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbox ylate ([(125)I]iomazenil) to measure brain perfusion and neuronal damage, respectively; 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) to measure cerebral glucose uptake. We assessed microglia activity on another group of mice using 2-[6-chloro-2-(4-[(125)I]iodophenyl)-imidazo[1,2-a]pyridin-3-yl]-N-ethyl-N-methyl -acetamide ([(125)I]CLINME). Radiotracer uptakes were measured in different brain regions and correlated. Microglia activity was also assessed using immunohistochemistry. Brain glutathione levels were measured to investigate oxidative stress. RESULTS: Significantly reduced perfusion values and significantly enhanced [(18)F]FDG and [(125)I]CLINME uptake was measured in the LPS-treated group. Following perfusion compensation, enhanced [(125)I]iomazenil uptake was measured in the LPS-treated group's hippocampus and cerebellum. In this group, both [(18)F]FDG and [(125)I]iomazenil uptake showed highly negative correlation to perfusion measured with ([(99m)Tc]HMPAO uptake in all brain regions. No significant differences were detected in brain glutathione levels between the groups. The CD45 and P2Y12 double-labeling immunohistochemistry showed widespread microglia activation in the LPS-treated group. CONCLUSIONS: Our results suggest that [(125)I]CLINME and [(99m)Tc]HMPAO SPECT can be used to detect microglia activation and brain hypoperfusion, respectively, in the early phase (4 h post injection) of systemic inflammation. We suspect that the enhancement of [(18)F]FDG and [(125)I]iomazenil uptake in the LPS-treated group does not necessarily reflect neural hypermetabolism and the lack of neuronal damage. They are most likely caused by processes emerging during neuroinflammation, e.g., microglia activation and/or immune cell infiltration

Industrial Development Policies and Performances in Southern China: Beyond the Specialised Industrial Cluster Program

The paper offers an updated picture of the policies implemented by the government of the Guangdong Province (China) to foster the industrial development and the technological upgrading of its territories. Among these policies is the promotion and the institutional acknowledgement of a growing number of industrial clusters, defined as “specialized towns”, characterized by a high spatial concentration of firms producing one specific item (or a limited range of similar products). In the view of the provincial and local governments these types of industrial development programs are used to increase firms agglomerations, spatial concentration and visibility, which in turn leads to increased specialization, industrial output, innovation and economic growth. However, little specific empirical evidence has been collected to support this view and the debate, at the national and international level, on the effectiveness of such interventions seems to be still largely ideological. The paper offers a contribution in this sense by offering a detailed description of the policy tools, by suggesting synthetic indexes to quantify policy efforts and industrial performances in Guangdong territories and by providing a first statistical analysis of these indexe

Single- or multiple-session viscosupplementation protocols for temporomandibular joint degenerative disorders: A randomized clinical trial

The aim of the study was to compare the effectiveness of two single-session protocols, either adopting high- (protocol A) or medium-molecular weight hyaluronic acid (protocol B), with the reference five-session protocol of temporomandibular joint (TMJ) lavage plus viscosupplementation (protocol C) in the management of chronic TMJ degenerative disorders. A randomized clinical trial (RCT) with ten participants per treatment group was designed, with multiple observation points, ending at 6 months after treatment. Pain levels on a 10-point VAS scale were selected as the primary outcome variable to rate treatment effectiveness, along with a number of secondary outcome parameters. Findings showed that Group C patients had the highest decrease in pain levels. Nonparametric permutation analyses revealed that the global effect of treatment was significantly different between the three protocols (P = 0\ub7024). Pairwise comparisons showed that the differences of treatment effect between the two single-session interventions were negligible (global P-value = 0\ub793). On the contrary, the five-session protocol was significantly superior to both single-session protocols (global P-values ranging from 0\ub7003 to 0\ub7012). In conclusion, in a population of age-, sex-, and psychosocial aspects-matched study groups, the standard of reference five-session protocol proved to be superior at 6 months as far as the decrease in pain levels was concerned, whilst there were no differences between the two single-session interventions. The absence of differences in treatment effect as for some other secondary clinical outcome variables may suggest that there is further space for future investigations attempting to reduce the number of multiple interventions for TMJ viscosupplementation

La formazione universitaria. Il terzo ciclo e le scuole di dottorato

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