534 research outputs found
Use of the OLFM4 protein in colorectal cancer diagnosis
The present invention provides a method for diagnosing KRAS mutations in colorectal cancers by measuring the level of OLFM4. In another aspect, the present invention relates a method of predicting the responds to a chemotherapeutic agent of a subject suffering from a colorectal cancer: according to the present invention, the by determining the OLFM4 levels. According to the present invention, the response can be predicted by determining the OLFM4 levels. This result in turn permits the design or the adaptation of a treatment of the said subject with the said chemotherapeutic agent
Algebraic damping in the one-dimensional Vlasov equation
We investigate the asymptotic behavior of a perturbation around a spatially
non homogeneous stable stationary state of a one-dimensional Vlasov equation.
Under general hypotheses, after transient exponential Landau damping, a
perturbation evolving according to the linearized Vlasov equation decays
algebraically with the exponent -2 and a well defined frequency. The
theoretical results are successfully tested against numerical -body
simulations, corresponding to the full Vlasov dynamics in the large limit,
in the case of the Hamiltonian mean-field model. For this purpose, we use a
weighted particles code, which allows us to reduce finite size fluctuations and
to observe the asymptotic decay in the -body simulations.Comment: 26 pages, 8 figures; text slightly modified, references added, typos
correcte
Large deviation techniques applied to systems with long-range interactions
We discuss a method to solve models with long-range interactions in the
microcanonical and canonical ensemble. The method closely follows the one
introduced by Ellis, Physica D 133, 106 (1999), which uses large deviation
techniques. We show how it can be adapted to obtain the solution of a large
class of simple models, which can show ensemble inequivalence. The model
Hamiltonian can have both discrete (Ising, Potts) and continuous (HMF, Free
Electron Laser) state variables. This latter extension gives access to the
comparison with dynamics and to the study of non-equilibri um effects. We treat
both infinite range and slowly decreasing interactions and, in particular, we
present the solution of the alpha-Ising model in one-dimension with
The Non--Ergodicity Threshold: Time Scale for Magnetic Reversal
We prove the existence of a non-ergodicity threshold for an anisotropic
classical Heisenberg model with all-to-all couplings. Below the threshold, the
energy surface is disconnected in two components with positive and negative
magnetizations respectively. Above, in a fully chaotic regime, magnetization
changes sign in a stochastic way and its behavior can be fully characterized by
an average magnetization reversal time. We show that statistical mechanics
predicts a phase--transition at an energy higher than the non-ergodicity
threshold. We assess the dynamical relevance of the latter for finite systems
through numerical simulations and analytical calculations. In particular, the
time scale for magnetic reversal diverges as a power law at the ergodicity
threshold with a size-dependent exponent, which could be a signature of the
phenomenon.Comment: 4 pages 4 figure
The cavity method for large deviations
A method is introduced for studying large deviations in the context of
statistical physics of disordered systems. The approach, based on an extension
of the cavity method to atypical realizations of the quenched disorder, allows
us to compute exponentially small probabilities (rate functions) over different
classes of random graphs. It is illustrated with two combinatorial optimization
problems, the vertex-cover and coloring problems, for which the presence of
replica symmetry breaking phases is taken into account. Applications include
the analysis of models on adaptive graph structures.Comment: 18 pages, 7 figure
Canonical Solution of Classical Magnetic Models with Long-Range Couplings
We study the canonical solution of a family of classical spin
models on a generic -dimensional lattice; the couplings between two spins
decay as the inverse of their distance raised to the power , with
. The control of the thermodynamic limit requires the introduction of
a rescaling factor in the potential energy, which makes the model extensive but
not additive. A detailed analysis of the asymptotic spectral properties of the
matrix of couplings was necessary to justify the saddle point method applied to
the integration of functions depending on a diverging number of variables. The
properties of a class of functions related to the modified Bessel functions had
to be investigated. For given , and for any , and lattice
geometry, the solution is equivalent to that of the model, where the
dimensionality and the geometry of the lattice are irrelevant.Comment: Submitted for publication in Journal of Statistical Physic
Ensemble Inequivalence in the Spherical Spin Glass Model with Nonlinear Interactions
We investigate the ensemble inequivalence of the spherical spin glass model
with nonlinear interactions of polynomial order . This model is solved
exactly for arbitrary and is shown to have first-order phase transitions
between the paramagnetic and spin glass or ferromagnetic phases for .
In the parameter region around the first-order transitions, the solutions give
different results depending on the ensemble used for the analysis. In
particular, we observe that the microcanonical specific heat can be negative
and the phase may not be uniquely determined by the temperature.Comment: 15 pages, 10 figure
Inequivalence of ensembles in a system with long range interactions
We study the global phase diagram of the infinite range Blume-Emery-Griffiths
model both in the canonical and in the microcanonical ensembles. The canonical
phase diagram is known to exhibit first order and continuous transition lines
separated by a tricritical point. We find that below the tricritical point,
when the canonical transition is first order, the phase diagrams of the two
ensembles disagree. In this region the microcanonical ensemble exhibits energy
ranges with negative specific heat and temperature jumps at transition
energies. These results can be extended to weakly decaying nonintegrable
interactions.Comment: Revtex, 4 pages with 3 figures, submitted to Phys. Rev. Lett., e-mail
[email protected]
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