1,311 research outputs found
Money and Goldstone modes
Why is ``worthless'' fiat money generally accepted as payment for goods and
services? In equilibrium theory, the value of money is generally not
determined: the number of equations is one less than the number of unknowns, so
only relative prices are determined. In the language of mathematics, the
equations are ``homogeneous of order one''. Using the language of physics, this
represents a continuous ``Goldstone'' symmetry. However, the continuous
symmetry is often broken by the dynamics of the system, thus fixing the value
of the otherwise undetermined variable. In economics, the value of money is a
strategic variable which each agent must determine at each transaction by
estimating the effect of future interactions with other agents. This idea is
illustrated by a simple network model of monopolistic vendors and buyers, with
bounded rationality. We submit that dynamical, spontaneous symmetry breaking is
the fundamental principle for fixing the value of money. Perhaps the continuous
symmetry representing the lack of restoring force is also the fundamental
reason for large fluctuations in stock markets.Comment: 7 pages, 3 figure
Dynamic plantar loading index detects altered foot function in individuals with rheumatoid arthritis but not changes due to orthotic use
Background Altered foot function is common in individuals with rheumatoid arthritis. Plantar pressure distributions during gait are regularly assessed in this patient group; however, the association between frequently reported magnitude-based pressure variables and clinical outcomes has not been clearly established. Recently, a novel approach to the analysis of plantar pressure distributions throughout stance phase, the dynamic plantar loading index, has been proposed. This study aimed to assess the utility of this index for measuring foot function in individuals with rheumatoid arthritis.Methods Barefoot plantar pressures during gait were measured in 63 patients with rheumatoid arthritis and 51 matched controls. Additionally, 15 individuals with rheumatoid arthritis had in-shoe plantar pressures measured whilst walking in standardized footwear for two conditions: shoes-only; and shoes with prescribed custom foot orthoses. The dynamic plantar loading index was determined for all participants and conditions. Patient and control groups were compared for significant differences as were the shod and orthosis conditions.Findings The patient group was found to have a mean index of 0.19, significantly lower than the control group's index of 0.32 (p > 0.001, 95% CI [0.054, 0.197]). No significant differences were found between the shoe-only and shoe plus orthosis conditions. The loading index was found to correlate with clinical measures of structural deformity.Interpretation The dynamic plantar loading index may be a useful tool for researchers and clinicians looking to objectively assess dynamic foot function in patients with rheumatoid arthritis; however, it may be unresponsive to changes caused by orthotic interventions in this patient group.</p
Synovial Tissue Response to Treatment with TNF Blockers in Peripheral Spondyloarthritis
This review describes the synovial response to treatment in peripheral spondyloarthritis (SpA). A series of recent studies demonstrates that the synovial histopathology is largely homogenous between different SpA subtypes and can be strongly modulated by effective treatment such as tumor necrosis factor (TNF) blockade. This includes a dramatic reduction of the infiltration with inflammatory cells (with the intriguing exception of B lymphocytes and plasma cells), a modulation of structural features such as vascularity, intimal lining layer hyperplasia, and ectopic lymphoid neogenesis, and a down-regulation of a variety of mediators involved in tissue damage. The analysis of tissue response to targeted therapies appears to be a novel and elegant approach to study the immunopathology of human peripheral SpA in vivo. Moreover, detailed cellular and molecular analysis of synovial features allows to identify synovial biomarkers of clinical response to therapeutic interventions which can be used in future early phase clinical trials in SpA
Expressiveness modulo Bisimilarity of Regular Expressions with Parallel Composition (Extended Abstract)
The languages accepted by finite automata are precisely the languages denoted
by regular expressions. In contrast, finite automata may exhibit behaviours
that cannot be described by regular expressions up to bisimilarity. In this
paper, we consider extensions of the theory of regular expressions with various
forms of parallel composition and study the effect on expressiveness. First we
prove that adding pure interleaving to the theory of regular expressions
strictly increases its expressiveness up to bisimilarity. Then, we prove that
replacing the operation for pure interleaving by ACP-style parallel composition
gives a further increase in expressiveness. Finally, we prove that the theory
of regular expressions with ACP-style parallel composition and encapsulation is
expressive enough to express all finite automata up to bisimilarity. Our
results extend the expressiveness results obtained by Bergstra, Bethke and
Ponse for process algebras with (the binary variant of) Kleene's star
operation.Comment: In Proceedings EXPRESS'10, arXiv:1011.601
Reconciling real and stochastic time: The need for probabilistic refinement
We conservatively extend anACP-style discrete-time process theorywith discrete stochastic delays. The semantics of the timed delays relies on time additivity and time determinism, which are properties that enable us to merge subsequent timed delays and to impose their synchronous expiration. Stochastic delays, however, interact with respect to a so-called race condition that determines the set of delays that expire first, which is guided by an (implicit) probabilistic choice. The race condition precludes the property of time additivity as the merger of stochastic delays alters this probabilistic behavior. To this end, we resolve the race condition using conditionally- distributed unit delays. We give a sound and ground-complete axiomatization of the process theory comprising the standard set of ACP-style operators. In this generalized setting, the alternative composition is no longer associative, so we have to resort to special normal forms that explicitly resolve the underlying race condition. Our treatment succeeds in the initial challenge to conservatively extend standard time with stochastic time. However, the 'dissection' of the stochastic delays to conditionally-distributed unit delays comes at a price, as we can no longer relate the resolved race condition to the original stochastic delays. We seek a solution in the field of probabilistic refinements that enable the interchange of probabilistic and non deterministic choices.Fil: Markovski, J.. Technische Universiteit Eindhoven; PaĂses BajosFil: D'argenio, Pedro Ruben. Universidad Nacional de CĂłrdoba. Facultad de Matemática, AstronomĂa y FĂsica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Baeten, J. C. M.. Technische Universiteit Eindhoven; PaĂses Bajos. Centrum Wiskunde & Informatica; PaĂses BajosFil: De Vink, E. P.. Technische Universiteit Eindhoven; PaĂses Bajos. Centrum Wiskunde & Informatica; PaĂses Bajo
Differential expression and response to infliximab treatment of specific macrophage subsets in inflammatory synovitis
Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy
Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present study analyzed whether histopathological features of synovium reflect specific phenotypes and/or global disease activity in SpA. Synovial biopsies obtained from 99 SpA and 86 RA patients with active knee synovitis were analyzed for 15 histological and immunohistochemical markers. Correlations with swollen joint count, serum C-reactive protein concentrations, and erythrocyte sedimentation rate were analyzed using classical and multiparameter statistics. SpA synovitis was characterized by higher vascularity and infiltration with CD163(+) macrophages and polymorphonuclear leukocytes (PMNs) and by lower values for lining-layer hyperplasia, lymphoid aggregates, CD1a(+) cells, intracellular citrullinated proteins, and MHC-HC gp39 complexes than RA synovitis. Unsupervised clustering of the SpA samples based on synovial features identified two separate clusters that both contained different SpA subtypes but were significantly differentiated by concentration of C-reactive protein and erythrocyte sedimentation rate. Global disease activity in SpA correlated significantly with lining-layer hyperplasia as well as with inflammatory infiltration with macrophages, especially the CD163+ subset, and with PMNs. Accordingly, supervised clustering using these synovial parameters identified a cluster of 20 SpA patients with significantly higher disease activity, and this finding was confirmed in an independent SpA cohort. However, multiparameter models based on synovial histopathology were relatively poor predictors of disease activity in individual patients. In conclusion, these data indicate that inflammatory infiltration of the synovium with CD163+ macrophages and PMNs as well as lining-layer hyperplasia reflect global disease activity in SpA, independently of the SpA subtype. These data support a prominent role for innate immune cells in SpA synovitis and warrant further evaluation of synovial histopathology as a surrogate marker in early-phase therapeutic trials in SpA.</p
The diagnostic value of synovial histopathology in undifferentiated inflammatory arthritis: a prospective study in 154 consecutive patients
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