18 research outputs found

    Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

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    Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%

    Un método de regularizacion de mallas de elementos finitos en modelos tridimensionales sólidos

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    La importancia que tiene en el análisis por elementos finitos la obtención de forma automática de una malla de calidad contrastada ha originado que en los últimos años se haya dedicado un gran esfuerzo al estudio del mallado adaptivo, de modo que se pueda corregir una malla a partir de la cuantificación de alguna magnitud representativa de la calidad de la misma, siguiendo algún esquema de refinado de malla. Lógicamente, los resultados de este proceso serán tanto más válidos cuanto mayor sea la calidad de la malla de partida. Este artículo expone un método de corrección de mallas de elementos finitos a partir de la modificación de las coordenadas de determinados nudos del mallado con el fin de obtener elementos con una relación de aspecto tan próxima a la unidad como sea posible. El método es completamente automático y aplicable a cualquier malla de elementos finitos correspondiente a un modelo 3D sólido, si bien su adaptación a otro tipo de modelos (por ejemplo, superficies o modelos planos) es imediata. El resultado es la obtención de una malla de mejor calidad, que puede utilizarse ventajosamente como punto de partida en un esquema de mallado adaptivo, dando lugar a resultados más aceptables

    Supplemental Material, robot_cirus2 - A robot for non-destructive testing weld inspection of offshore mooring chains

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    <p>Supplemental Material, robot_cirus2 for A robot for non-destructive testing weld inspection of offshore mooring chains by A Hernandez, O Altuzarra, V Petuya, Ch Pinto, and E Amezua in International Journal of Advanced Robotic Systems</p
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