Day mode as one of the factors of health technologies for students with mental retardation at the level of preschool education

The article is devoted to problems of organization of day regimen of preschool children with mental retardation. Features of organization of protective day regimen of preschool children with mental retardation are described in detailРассмотрена организация режима дня для обучающихся с умственной отсталостью на уровне дошкольного образования. Подробно описаны особенности организации охранительного режима дн

Day mode as a health factor in preschool education of children with mental retardation

The article is devoted to problems of organization of day regimen of preschool children with mental retardation. Features of organization of protective day regimen of preschool children with mental retardation are described in detailСтатья посвящена проблеме организации режима дня для обучающихся с умственной отсталостью на уровне дошкольного образования. Подробно описаны особенности организации охранительного режима дня для обучающихся с умственной отсталость

Brittle Strength of the VVER Pressure Vessel Steels under Operation Conditions

Complex of mechanical tests and fractographic studies of various sample types were conducted for VVER pressure vessel steels. The brittle fracture sources (origins) were revealed: “non-metallic inclusions” and “structural boundaries”. The computational-experimental technique for evaluation of the local normal stress parameter that characterizes strength of the origin was performed. Values of the local normal stressfor the “structural boundary” origin type was demonstrated to be decreasing after thermal and radiation embrittlement due to decreasing in cohesive strength of grain boundaries by virtue of thermo- and radiation- stimulated diffusion of the impurities to grains boundaries. Keywords: reactor pressure vessel, fractography, local normal stress, brittle fracture, origi

Creation of Digital Opportunities for the Participation of Residents in the Region Development as a Factor of the Government Efficiency

No one better than people living in the region can know what is required for the development of the region. The modern government, oriented towards the development of an active civil society, should make this basic postulate the basis of a new management paradigm

Structure and Phase Composition of Zirconium Fuel Claddings in Initial State and after Creep Tests

The article's abstract is no available

The new technologies of high-throughput single-cell RNA sequencing

A wealth of genome and transcriptome data obtained using new generation sequencing (NGS) technologies for whole organisms could not answer many questions in oncology, immunology, physiology, neurobiology, zoology and other fields of science and medicine. Since the cell is the basis for the living of all unicellular and multicellular organisms, it is necessary to study the biological processes at its level. This understanding gave impetus to the development of a new direction – the creation of technologies that allow working with individual cells (single-cell technology). The rapid development of not only instruments, but also various advanced protocols for working with single cells is due to the relevance of these studies in many fields of science and medicine. Studying the features of various stages of ontogenesis, identifying patterns of cell differentiation and subsequent tissue development, conducting genomic and transcriptome analyses in various areas of medicine (especially in demand in immunology and oncology), identifying cell types and states, patterns of biochemical and physiological processes using single cell technologies, allows the comprehensive research to be conducted at a new level. The first RNA-sequencing technologies of individual cell transcriptomes (scRNA-seq) captured no more than one hundred cells at a time, which was insufficient due to the detection of high cell heterogeneity, existence of the minor cell types (which were not detected by morphology) and complex regulatory pathways. The unique techniques for isolating, capturing and sequencing transcripts of tens of thousands of cells at a time are evolving now. However, new technologies have certain differences both at the sample preparation stage and during the bioinformatics analysis. In the paper we consider the most effective methods of multiple parallel scRNA-seq using the example of 10XGenomics, as well as the specifics of such an experiment, further bioinformatics analysis of the data, future outlook and applications of new high-performance technologies

The Effect of Reducing Irradiation Temperature on the Structure and Radiation Embrittlement Mechanism of RPV Steels

A complex research of RPV 15Kh2NMFA class 1 steel in different states was performed: in the initial state and after irradiatiion at different temperatures (50-300∘C). Low temperature (50-140∘C) irradiation was shown to cause the formation of dislocation loops of ultrahigh density. At the same time radiation-induced precipitates, being the main radiation-induced hardening phase at irradiation temperature of VVER reactors (∼300∘C), were absent. This leads to a higher radiation embrittlement rate after low-temperature irradiation as compared with irradiation at operating temperatures of VVER-1000. The radiation embrittlement coefficient values are 8.7 and 1.45 for (120-140)∘C and (290-315)∘C irradiation temperature, respectively

Contribution of Hardening Mechanism to VVER-1000 RPV Welds Flux Effect

Systematic differences in the radiation embrittlement kinetics of steels irradiated with different fluxes requires a clear understanding and assessment of the mechanisms responsible for the flux effect. This paper presents results of research of hardening mechanism contribution to flux effect of VVER-1000 reactor pressure vessel (RPV) welds. Transmission electron microscopy (TEM) and atom probe tomography (APT) investigations were carried out. Studies of hardening phases of RPV-steel (VVER-1000) after accelerated irradiation allowed to estimate the contribution of the hardening mechanism to flux effect. Keywords: reactor pressure vessel, hardening mechanism, flux effec