Change in the surface density of immobilized enzyme molecules due to photoelectron processes in a silicon substrate

The work was supported by the Russian Foundation for Basic Research, projects no. 16-08-00524

Museum space as an educational resource

Рассматривается проблема создания эффективного музейного пространства, включенного в современную образовательную системуThe article is devoted to the problem of creating an effective museum space, included into the modern educational syste

The problem of quality of modern education in the philosophical dimension

The modern practice-oriented education should be carried out by learning the situations of instability, the mechanisms of the new conditions and self-organization. Metasubject and reflexive knowledge takes up position of relevant. Modern learning process can be represented through cultural tests, maze, travel; it becomes a universal method of cultural and historical reconstructionСовременное практико-ориентированное образование должно осуществляться путем изучения состояний неустойчивости, механизмов возникновения нового и самоорганизации. Актуальными становятся метапредметные и рефлексивные знания. Современный процесс обучения может быть представлен через культурные аналогии лабиринта, испытания, путешествия; универсальным становится метод культурно-исторической реконструкци

APPLICATION OF THE TECHNIQUE OF COMPLETE ASSIMILATION OF KNOWLEDGE IN THE COURSE OF FORMATION OF PEDAGOGICAL COMPETENCE OF STUDENTS-DESIGNERS

В статье рассматривается специфика применения таксономии образовательных целей Б. Блума в ходе прохождения магистрантами-дизайнерами педагогической практики. Показана целесообразность и эффективность освоения практикантами технологии конструированияThe article deals with the specifics of the application of the taxonomy of educational purposes B. Bloom in the course of undergraduates-designers teaching practice. Expediency and efficiency of development of technology of designing by trainees is show

TRANSFORMATION OF PUBLIC PROCUREMENT OF INDUSTRIAL PRODUCTS TAKING INTO ACCOUNT THE ENVIRONMENTAL FACTOR

Actual problems of industry and environmental aspects of their manifestation have been designated. To reduce the negative impact of industry on the environment, the authors suggest using public procurement tools. The main measures carried out by the state in the interests of ensuring environmental-oriented purchases of industrial products have been given. It has been proposed to expand the practice of using life-cycle contracts as the main way of state support for environmental-oriented procurement, which will subsequently allow you to use effectively available resources, taking into account the environmental factor. There is a large number of different methods for determining the stages of the product life cycle. An attempt was made in this article to describe the application of the environmental factor at each stage of the product life cycle using the example of industry

The impact of the Hsp67Bc gene product on Drosophila melanogaster longevity, fecundity, and acute heat stress tolerance

Drosophila melanogaster Hsp67Bc is a heat- and cold-inducible small heat shock protein that participates in the prevention of aggregation of misfolded proteins and in macroautophagy regulation. Overexpression of the Hsp67Bc gene has been shown to enhance macroautophagy in Drosophila S2 cells, and the deletion of this gene leads to the formation of a slightly increased number of autophagic vacuoles in the fruit f ly brain neurons. Recently, we found that Hsp67Bc-null D. melanogaster f lies have poor tolerance to cold stress (0 °C) of various durations. In the present work, we investigated how the Hsp67Bc gene deletion affects the f itness of fruit f lies under normal conditions and their tolerance to elevated temperatures at different developmental stages. Larvae and pupae were not adversely affected by the Hsp67Bc gene deletion, and adult Hsp67Bc-null f lies showed an extended lifespan in comparison with the control at normal (24–25 °C) and elevated temperature (29 °C), and after acute heat stress (37 °C, 2 h). At the same time, the fecundity of the mutant females was lower by 6–13 % in all tested environments, except for permanent maintenance at 29 °C, where the mean numbers of eggs laid by the mutant and control f lies were equal. We explain this phenomenon by a reduced number of ovarioles in Hsp67Bc-null females and enhanced macroautophagy in their germaria, which promotes the death of forming egg chambers. In addition, short heat stress (37 °C, 2 h), which increased the control line’s longevity (an effect common for a wide range of organisms), had a negative impact on the lifespan of Hsp67Bc-null f lies. Therefore, Hsp67Bc-null D. melanogaster have an extended lifespan under normal and elevated temperature conditions, and reduced fecundity and thermal stress tolerance

Theory of differential inclusions and its application in mechanics

The following chapter deals with systems of differential equations with discontinuous right-hand sides. The key question is how to define the solutions of such systems. The most adequate approach is to treat discontinuous systems as systems with multivalued right-hand sides (differential inclusions). In this work three well-known definitions of solution of discontinuous system are considered. We will demonstrate the difference between these definitions and their application to different mechanical problems. Mathematical models of drilling systems with discontinuous friction torque characteristics are considered. Here, opposite to classical Coulomb symmetric friction law, the friction torque characteristic is asymmetrical. Problem of sudden load change is studied. Analytical methods of investigation of systems with such asymmetrical friction based on the use of Lyapunov functions are demonstrated. The Watt governor and Chua system are considered to show different aspects of computer modeling of discontinuous systems